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Influence of cognitive and emotional factors on motor dual-task performance in nursing home residents. The mediating and moderating roles of cognition, concerns about falling, well-being, and depressive symptoms. A cross-sectional observational study
BackgroundThis study aimed (1) to compare walking performance under single (ST) and dual-task (DT) conditions with varying...
Associations between the oral microbiome, number of teeth and frailty among American adults: A cross-sectional study from NHANES 2009–2012
BackgroundThe intricate interrelationship between oral health, the number of teeth, oral microbiota, and frailty remains l...
Mechanistic insights into EIF6 as a target of Apigenin in alleviating chondrocyte senescence
PurposeApigenin, a flavonoid found in edible plants, has demonstrated therapeutic potential in various diseases, but its r...
Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis
Volume 203, May 2025, 112729Author links open overlay panel, , , , Highlights•Rheumatoid arthritis and sarcopenia share 25...
Age related gut microbiota regulates energy-related metabolism to influence natural aging phenotypes in the heart
Volume 203, May 2025, 112734Author links open overlay panel, , , , , , , , , , , , , , , Highlights•Aging induced changes ...
Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques
As the global human population rapidly ages and diseases of aging become more prevalent, preclinical models of age-related...
Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community
PurposeTo examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 com...
Age-related peculiarities of antibody-mediated humoral immune response following SARS-CoV-2 infection
Thousands of articles were published about the COVID-19 disease and hundreds about the immune response. But still little i...
Corrigendum to “Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition” [Exp. Gerontol. Volume 89 (2017), 45–56]
Volume 203, May 2025, 112733Author links open overlay panelJingxing Zhang a, Qiong Cai a, Ming Jiang c, Yigang Liu a, Hua ...
Sarcopenic obesity is associated with long-term trajectories of physical activity and sedentary behavior
Volume 204, 1 June 2025, 112752Author links open overlay panel, , Highlights•Sarcopenic obesity is associated with adverse...
Molecular mechanism of melatonin-mediated mitophagy regulating proline production to ameliorate skin aging
Collagen loss is one of the major contributor to signs of skin aging such as dryness, roughness, and wrinkle formation, wh...
Association of blood ethylene oxide levels with osteoarthritis and rheumatoid arthritis: Evidence from NHANES (2013–2020)
ObjectivesOsteoarthritis (OA) and rheumatoid arthritis (RA) are common conditions with important public health implication...
Balancing benefits and risks of aerobic exercise for aging and musculoskeletal health
BackgroundLong-term exercise is recognized as one of the most effective means of maintaining health after aging, but the r...
miRNA and piRNA differential expression profiles in Alzheimer's disease: A potential source of pathology and tool for diagnosis
Alzheimer's Disease (AD) is the most prevalent form of dementia and one of the leading causes of death in the United State...
Long-term prognostic value of CRP–albumin–lymphocyte index in elderly patients with heart failure with preserved ejection fraction
BackgroundHeart failure with preserved ejection fraction (HFpEF) is a complex and heterogeneous clinical condition charact...
Effects of Bufexamac, a class IIb HDAC inhibitor, on behavior and neuropathological features in an Aβ-induced rat model of Alzheimer's disease
It has been suggested that Alzheimer's disease (AD), a progressive neurological condition, can potentially be treated thro...
Baicalin alleviates intervertebral disc degeneration by inhibiting the p38 MAPK signaling pathway
BackgroundIntervertebral disc degeneration (IVDD) represents a prevalent degenerative pathology of the spinal, primarily p...
Age at menarche and risk of non-alcoholic fatty liver disease: Insights from the NHANES 2017–2020 and Mendelian randomization analyses
Volume 204, 1 June 2025, 112748Author links open overlay panel, , , , , , , , , Highlights•Age at menarche (AAM) is consid...
UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosis
Osteoporosis is a prevalent public health issue and the underlying mechanism is an imbalance in bone remodeling. Excessive...
Sarcopenia index based on serum creatinine and cystatin C is associated with all-cause mortality in patients aged 50 and over with hip fracture
BackgroundSarcopenia index (SI), calculated as serum creatinine/cystatin C × 100, has emerged as a potential marker for mu...
Exploring the potential performance of 0.2 T low-field unshielded MRI scanner using deep learning techniques
Exploring the potential performance of 0.2 T low-field unshielded MRI scanner using deep learning techniques
Using deep learning-based techniques to overcome physical limitations and explore the potential performance of 0.2 T low-f...
Anatomical zone and tissue type impacts the repeatability of quantitative MRI parameters and radiomic features for longitudinal monitoring of treatment response in the prostate
Anatomical zone and tissue type impacts the repeatability of quantitative MRI parameters and radiomic features for longitudinal monitoring of treatment response in the prostate
To (1) establish the repeatability coefficient (%RC) of region of interest (ROI) and voxel-wise measurements of a comprehe...
Clinical validation of fully automated cartilage transverse relaxation time (T2) and thickness analysis using quantitative DESS magnetic resonance imaging
Clinical validation of fully automated cartilage transverse relaxation time (T2) and thickness analysis using quantitative DESS magnetic resonance imaging
To clinically validate a fully automated cartilage segmentation technique from quantitative double-echo steady-state (qDES...
Comparing repeatability metrics for quantitative susceptibility mapping in the head and neck
Comparing repeatability metrics for quantitative susceptibility mapping in the head and neck
Quantitative susceptibility mapping (QSM) is a technique that has been demonstrated to be highly repeatable in the brain. ...
Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study
Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study
To report T1/T2-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired w...
A dual-stage framework for segmentation of the brain anatomical regions with high accuracy
A dual-stage framework for segmentation of the brain anatomical regions with high accuracy
This study presents a novel deep learning-based framework for precise brain MR region segmentation, aiming to identify the...
Whole pancreas water T mapping at 3 Tesla
Whole pancreas water T mapping at 3 Tesla
A fast T1 mapping method of the whole pancreas remains a challenge, due to the complex anatomy of the organ. In addition, ...
MRI acquisition and reconstruction cookbook: recipes for reproducibility, served with real-world flavour
MRI acquisition and reconstruction cookbook: recipes for reproducibility, served with real-world flavour
MRI acquisition and reconstruction research has transformed into a computation-driven field. As methods become more sophis...
Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data
Myelin water fraction mapping with joint inversion of gradient-echo and spin-echo data
Accurate estimation of brain myelin-water content from multi-echo data is challenging due to the inherent ill-posedness of...
Using intra-voxel incoherent motion MRI to dynamically evaluate the attenuating effects of donafenib combined with carvedilol in a thioacetamide-induced hepatic fibrosis rat model
Using intra-voxel incoherent motion MRI to dynamically evaluate the attenuating effects of donafenib combined with carvedilol in a thioacetamide-induced hepatic fibrosis rat model
This study aimed to dynamically evaluate the attenuating effects of donafenib combined with carvedilol using intra-voxel i...
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