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A systematic in-silico functional and structural analysis reveals deleterious nsSNPs in the Human CSF1R Gene
Colony Stimulating Factor-1 Receptor (CSF1R) is a tyrosine kinase transmembrane receptor that plays a vital role in innate...
SPIN.DOC induces cellular transformation of NIH3T3 normal mouse fibroblast cells
SPIN.DOC was discovered as a transcriptional co-repressor of wingless related integration site (WNT) pathway. However, it ...
In silico exploring of the epigenetic factors in teratozoospermia: A focus on IGF2BP2
Teratozoospermia is an abnormal sperm morphology that is a common cause of male infertility. Epigenetic factors have been ...
Molecular identification of KRAS, BRAF, and PIK3CA mutations in colorectal cancer patients from the Kurdistan region of Iraq
Colorectal cancer (CRC) emerged due to genetic mutations that fuel tumor development and influence patient outcomes. This ...
Role of VOPP1 in regulation of Paclitaxel response and EMT process during ovarian tumor progression
Ovarian cancer (OC) is one of the most common malignancies of the genitourinary system in women that has a high mortality ...
Expression patterns of circRFX3 and miR-587 in colorectal cancer patients
Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has est...
HIV-1 reverse transcriptase subtyping revealed CRF35-AD as a current subtype in the northeast of Iran
Previously, the sequence of the HIV-1 reverse transcriptase gene was analyzed to identify mutations associated with drug r...
Comprehensive computational analysis of deleterious nsSNPs in PTEN gene for structural and functional insights
Single nucleotide polymorphisms (SNPs) are pivotal in understanding the genetic basis of complex disorders. Among them, no...
Gene co-expression network analysis reveals relationship between leukocyte fraction and genomic instability in dedifferentiated liposarcoma
Dedifferentiated Liposarcoma (DDLPS) is one of the common subtypes of liposarcoma that is considered a highly malignant ca...
Breast cancer susceptibility is associated with Cyclin D1 single nucleotide polymorphisms in Iran: A case-control study
Breast cancer (BC) is the main cause of cancer-related death in women worldwide. We evaluated the association between the ...
The importance of TP53 status in cancer therapy: The example of chronic lymphocytic leukemia
The TP53 gene encodes the tumor suppressor protein p53, which plays a critical role in genomic stability and cell cycle re...
Effect of 30-day Ramadan fasting on autophagy pathway and metabolic health outcome in healthy individuals
During Ramadan, Muslims fast to spiritually prepare their bodies and spirits. The autophagy pathway restores cellular home...
A review on diabetes and oral cancer: Molecular links and implications
Diabetes mellitus has been linked to an increased risk of oral cancer, with hyperglycemia and chronic inflammation contrib...
Dysregulated LINC01133 expression in laryngeal carcinoma: Prognostic implications and predicted ceRNA interactome
Long non-coding RNAs (lncRNAs) have recently emerged as critical regulators of oncogenic or tumor-suppressive pathways in ...
Non-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8
The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the vir...
Dysregulated genes in HIGK-treated F. nucleatum and their possible association with HNSCC
The present study aims to identify the differentially expressed genes in HIGK treated with Fusobacterium nucleatum (Fn) an...
Prediction the functional impacts of highly deleterious non-synonymous variants of TSGA10 gene
Testis specific gene antigen 10 (TSGA10) is a protein which has roles in spermatogenesis and cancers so that deletion or m...
Isolation and characterization of thermotolerant hydrocarbon degrading bacteria which sustained the activity at extreme salinity and high osmotic conditions
The bioremediation method is considered an economical and environmentally friendly strategy for the remediation of oil-con...
Expressing red fluorescent protein on the surface of Escherichia coli using C-terminal domain of autotransporters
The Type V secretion system, or “autotransporter”, is a secretion system that enables bacteria to directly export proteins...
IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study
Genetic polymorphisms in interleukin-13 (IL13) gene have been associated with asthma susceptibility in different ethniciti...
A CRISPR-HITI strategy approach to improve CHO cell viability by modifying the 3'UTR of Caspase 8 Associated Protein 2
Chinese Hamster Ovary (CHO) cells are essential in biopharmaceutical manufacturing.  Scientists use CRISPR to enhance prod...
Evaluation of several strategies for controlling canker plant disease caused by Pseudomonas syringae
Pseudomonas syringae is a gram-negative bacterium that causes a diversity of diseases in numerous plants. Strategies to in...
A comprehensive in silico analysis of mutation spectrum of maple syrup urine disease (MSUD) genes in Iranian population
Maple syrup urine disease (MSUD) represents an infrequent metabolic disease precipitated by an insufficiency of the enzyma...
In silico analysis for SARS-CoV-2 detection in the context of genetic variability of the Algerian omicron variant
The risk to public health conferred by the Omicron variant is still not completely clear, although its numerous gene mutat...
Comparison of inflammatory molecular mechanisms between osteoarthritis and rheumatoid arthritis via gene microarrays
Osteoarthritis (OA) and rheumatoid arthritis (RA) treatment requires exact arthritis type diagnosis. We compared inflammat...
Down-regulation of key regulatory factors in sphingosine-1-phosphate (S1P) pathway in human lung fibroblasts transfected with selected microRNAs
Sphingosine 1 phosphate (S1P) is involved in the pathogenesis of asthma by stimulation of the alpha-smooth muscle actin (S...
The hepatoprotective effects of sitagliptin against cyclophosphamide-induced hepatotoxicity in rat
Hepatotoxicity is a serious side effects of cyclophosphamide. Thus, the present research investigates the protective prope...
In-silico comparison of fungal and bacterial asparaginase enzymes
L-asparaginase is a commercial enzyme with a wide variety of applications. Asparaginase is known as an anti-cancer agent t...
Clinical profile of FTL3-ITD mutation in West Algerian population with acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the abnormal and ra...
The effects of NLRP3 rs10754558 and rs4612666 polymorphisms on preeclampsia susceptibility, onset, and severity: a case-control study and in silico analysis
Preeclampsia (PE) is one of the serious complications of pregnancy and its exact etiology is unknown. Inflammasomes are mu...
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