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The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
The VEGF decoy receptor soluble Fms-like tyrosine kinase 1 binds to macrophages
Soluble Fms-like Tyrosine kinase-1 (sFLT1) is a native inhibitor of VEGF, best known for its antiangiogenic effects in pre...
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
SDF-1α mRNA therapy in peripheral artery disease
SDF-1α mRNA therapy in peripheral artery disease
Stromal cell-derived factor-1 alpha (SDF-1α) is a promising target for therapeutic angiogenesis in ischemic diseases ...
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Vascular repair and regeneration are critical for tissue homeostasis. Endothelial colony forming cells (ECFCs) are vessel-...
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Polysialic acid regulates glomerular microvasculature formation by interaction with VEGF-A188 in mice
Vascular endothelial growth factor A (VEGF-A) is a key signalling protein that stimulates blood vessel development and rep...
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
High-throughput differentiation of human blood vessel organoids reveals overlapping and distinct functions of the cerebral cavernous malformation proteins
Cerebral cavernous malformations (CCMs) are clusters of thin-walled enlarged blood vessels in the central nervous system t...
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
An endothelial specific mouse model for the capillary malformation mutation p.R183Q
Capillary malformation (CM) is a congenital, non-hereditary lesion composed of enlarged and tortuous blood vessels. CM is ...
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Genetic deletion of microRNA-15a/16-1 in pericytes stimulates cerebral angiogenesis and promotes functional recovery after ischemic stroke
Stroke is a leading cause of mortality and disability globally. Despite advancements in acute stroke therapies, patient ou...
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
Endothelial GTPBP3 directs developmental angiogenesis and neovascularization after limb ischemia via the mtROS/HRl/ATF4/mTORC1 axis
GTP binding protein 3 (GTPBP3) is a highly conserved enzyme involved in tRNA modification, is essential for 5-taurinomethy...
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Proteoglycans and glycosaminoglycans: critical regulators in angiogenesis, vasculogenesis, and vascularized tissue engineering
Reconstruction of the microvascular network is essential for tissue regeneration and functional repair. However, inadequat...
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Mechanistic insights into endometriosis: roles of and L-carnitine in lesion development and angiogenesis
Retrograde menstruation is a widely recognized etiological factor for endometriosis (EMs); however, it is not the sole cau...
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Semaphorin 3A protects against thoracic aortic aneurysm dissection by suppressing aortic angiogenesis
Thoracic aortic aneurysm (TAA) is life-threatening once developing to sudden dissection (TAAD) or rupture. The pathogenesi...
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
In vivo profiling of the endothelium using ‘AngioTag’ zebrafish
Vascular endothelial cells in vivo are exquisitely regulated by their local environment, which is disrupted or absent when...
Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Angiopoietin-2 binds to FGFR2, inhibits FGF-FGFR2 signaling, and delays cutaneous wound healing by inhibiting wound angiogenesis
Wound healing is an essential repair process, and impaired wound healing is a common and sometimes debilitating medical pr...
RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation
RE: acute aortic dissection in a patient with hereditary hemorrhagic telangiectasia associated with juvenile polyposis due to SMAD4 mutation
Conflict of interest The authors declare no competing inter...
UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes
UHRF1 in endothelial cells is essential for angiogenesis and associated with the activation of pro-angiogenic signaling pathways and expression of endothelial genes
Epigenetics is increasingly recognized as a crucial factor in angiogenesis. Ubiquitin-like with PHD and RING Finger Domain...
MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14
MY-1 promotes angiogenesis in the ischemic hindlimbs by regulating the stability of CDC42 via PSMD14
Critical limb ischemia (CLI) is a refractory peripheral artery disease characterized by tissue ischemia, presenting signif...
Pathophysiology of endothelial dysfunction in Fontan circulation: from bench to bedside and back again
Pathophysiology of endothelial dysfunction in Fontan circulation: from bench to bedside and back again
The Fontan procedure is a definitive surgical approach for complex cardiac malformations, redirecting systemic venous bloo...
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway
G3BP1 maintains endothelial barrier integrity through dual mechanisms: direct stabilization of junction protein mRNAs and suppression of the inflammatory MYD88-ARNO-ARF6 pathway
Vascular permeability, crucial for organ function, relies on the endothelial barrier formed by intercellular junctions (AJ...
Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets
Call to action: British and Irish hypertension society position statement on blood pressure treatment thresholds and targets
In this position statement the British and Irish Hypertension Society (BIHS) present a review of the current evidence for ...
Vagal dysfuction in resistant hypertension: no longer the “cinderella” of the autonomic cardiovascular profile
Vagal dysfuction in resistant hypertension: no longer the “cinderella” of the autonomic cardiovascular profile
The past fifteen years have seen a renewed interest of clinicians and researchers for the evaluation of the sympathetic ne...
Exploration of potential therapeutic target genes for preeclampsia through genetic analysis
Exploration of potential therapeutic target genes for preeclampsia through genetic analysis
Preeclampsia (PE) is a prevalent and severe pregnancy-related complication, for which effective intervention targets remai...
Association between bullous pemphigoid and hypertension: a systematic review and meta-analysis of observational studies
Association between bullous pemphigoid and hypertension: a systematic review and meta-analysis of observational studies
Studies have indicated a relationship between bullous pemphigoid (BP) and hypertension, but the findings remain controvers...
Cerebrovascular reactivity impairment in resistant hypertension
Cerebrovascular reactivity impairment in resistant hypertension
Resistant hypertension (RH) is defined as office systolic blood pressure (BP) that remains uncontrolled despite the concur...
Associations between cardiovascular health metrics in life’s essential 8 and incident hypertension: The LIFE Study
Associations between cardiovascular health metrics in life’s essential 8 and incident hypertension: The LIFE Study
The American Heart Association’s Life’s Essential 8 is a set of modifiable lifestyle habits and risk factors u...
A systematic review and meta-analysis of digital interventions targeting lifestyle factors in patients with hypertension
A systematic review and meta-analysis of digital interventions targeting lifestyle factors in patients with hypertension
Hypertension is a major risk factor for cardiovascular disease, for which the management involves both lifestyle modificat...
Impact of moderate to vigorous physical activity on systemic vascular resistance in Danish adults with recently diagnosed type 2 diabetes: a cross-sectional study
Impact of moderate to vigorous physical activity on systemic vascular resistance in Danish adults with recently diagnosed type 2 diabetes: a cross-sectional study
Strenuous physical activity alleviates the risk of elevated blood pressure (BP) presumably through a reduction in systemic...
Small Interfering RNA Therapy for the Management and Prevention of Hypertension
Small Interfering RNA Therapy for the Management and Prevention of Hypertension
To review currently existing knowledge on a new type of antihypertensive treatment, small interfering RNA (siRNA) targetin...
Guidance for Prescribing Oral Antihypertensive Medications in the Emergency Department
Guidance for Prescribing Oral Antihypertensive Medications in the Emergency Department
To review the most current recommendations regarding assessment and treatment of asymptomatic hypertension treatment in th...
Sodium-Directed Crosstalk Between Immune Cells and Lymphatic Vessels
Sodium-Directed Crosstalk Between Immune Cells and Lymphatic Vessels
The role of the lymphatic system in clearing extravasated fluids, lipid transport, and immune surveillance is well establi...
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