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Socioeconomic deprivation and its association with polypharmacy in England: results from a national cross-sectional survey
Socioeconomic deprivation and its association with polypharmacy in England: results from a national cross-sectional survey
Polypharmacy is a growing public health concern, yet its association with area-level socioeconomic deprivation in England ...
Does direct oral anticoagulant lead-in dosing following initial parenteral therapy affect clinical outcomes in acute venous thromboembolism?: A retrospective cohort study
Does direct oral anticoagulant lead-in dosing following initial parenteral therapy affect clinical outcomes in acute venous thromboembolism?: A retrospective cohort study
Initiation of direct oral anticoagulants (DOAC) for the management of venous thromboembolism (VTE) typically includes a le...
Community pharmacists’ practices and clinical reasoning towards hospital discharge prescription: a study using simulations and retrospective think-aloud methodology
Community pharmacists’ practices and clinical reasoning towards hospital discharge prescription: a study using simulations and retrospective think-aloud methodology
The roles of community pharmacists have evolved from dispensing medications to clinical decision makers. This shift requir...
Development of a machine learning-based risk prediction model and analysis of risk factors for docetaxel-induced bone marrow suppression in breast cancer patients
Development of a machine learning-based risk prediction model and analysis of risk factors for docetaxel-induced bone marrow suppression in breast cancer patients
Breast cancer is the most prevalent malignancy in women worldwide. Docetaxel-based chemotherapy is commonly used for treat...
Real-world safety profile of mitomycin: signal detection and time-to-onset analysis from FDA adverse event reporting system and VigiAccess databases
Real-world safety profile of mitomycin: signal detection and time-to-onset analysis from FDA adverse event reporting system and VigiAccess databases
Mitomycin, a cytotoxic antitumor antibiotic, has been approved for the treatment of low-grade upper tract urothelial carci...
Incidence and risk factors of acute kidney injury in patients with polypharmacy: a systematic review and meta-analysis
Incidence and risk factors of acute kidney injury in patients with polypharmacy: a systematic review and meta-analysis
Polypharmacy, typically defined as the use of five or more medications, has become increasingly common among older adults ...
Exploring the role of community pharmacists in perioperative management of antithrombotic agents: a qualitative study of barriers, facilitators, and future directions
Exploring the role of community pharmacists in perioperative management of antithrombotic agents: a qualitative study of barriers, facilitators, and future directions
Antithrombotic agents are considered as high-risk medications, particularly during the perioperative period, because of th...
Evaluating the quality, feasibility and patient satisfaction of medication history taking by telephone for patients with scheduled admissions: a pilot study
Evaluating the quality, feasibility and patient satisfaction of medication history taking by telephone for patients with scheduled admissions: a pilot study
Medication history taking at hospital admission is still prone to errors. Despite numerous quality improvement initiatives...
Experiences and challenges of implementing clinical medication reviews in daily practice: a mixed-methods study
Experiences and challenges of implementing clinical medication reviews in daily practice: a mixed-methods study
Organisational problems still prevent widespread implementation of clinical medication reviews. The Opti-Med2 method was d...
Optimising end-of-life geriatric pharmacotherapy: a hospital-based retrospective cohort study of deprescribing early in the care trajectory before hospice transition
Optimising end-of-life geriatric pharmacotherapy: a hospital-based retrospective cohort study of deprescribing early in the care trajectory before hospice transition
Polypharmacy and potentially inappropriate medications (PIMs) are common among terminally ill older people and often persi...
Tele-triaging: a qualitative study exploring pharmacists’ clinical decision-making in a Poisons Information Centre using interviews and a clinical vignette
Tele-triaging: a qualitative study exploring pharmacists’ clinical decision-making in a Poisons Information Centre using interviews and a clinical vignette
Specialists in Poisons Information (SPIs), most of whom are pharmacists, work in Australian Poisons Information Centres (P...
Effect of pemafibrate on high-density lipoprotein cholesterol levels and subspecies in a patient with cholesteryl ester transfer protein deficiency: A case report with mechanistic insights
Available online 22 July 2025Author links open overlay panel, , , , Highlights•Cholesteryl ester transfer protein (CETP) d...
Brief communication: Strong concordance of the North American Familial Chylomicronemia Syndrome Score with a positive genetic diagnosis in patients from the Balance study
BACKGROUNDPatients with familial chylomicronemia syndrome (FCS) are often misdiagnosed. A positive genetic diagnosis is co...
Self-medication to lower LDL cholesterol and to treat statin-associated muscle symptoms in patients with statin intolerance
BACKGROUNDSelf-medication with supplements or over-the-counter drugs is very frequent despite limited evidence on efficacy...
Experiences of people with elevated lipoprotein(a) and the impact on family and child screening
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein (LDL) particle additionally bound to apolipoprotein(a) [apo(a)], and i...
Performance of the FIND-FH machine learning algorithm for the identification of individuals with suspected familial hypercholesterolemia
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of cholesterol metabolism that results in high levels...
Choosing the Optimal Non-Statin Lipid Lowering Therapies for Statin-Intolerant Patients: A Systematic Review and Network Meta-Analysis
Cardiovascular diseases (CVD) are a leading cause of morbidity and mortality globally, with elevated low-density lipoprote...
HDL remodelling and enrichment with apoCIII and apoE in Indigenous Australians
BACKGROUNDIndigenous Australians have an increased risk of type 2 diabetes mellitus (T2DM) and premature cardiovascular di...
Updated meta-analysis of the lipid-lowering efficacy of Obicetrapib: A comprehensive review of randomized controlled trials
BackgroundDespite standard lipid-lowering therapy, cardiovascular risk remains high in patients with hyperlipidemia. Obice...
Triglyceride-glucose index and 28-day all-cause mortality in critically ill obese patients: A commentary on methodological considerations
Available online 8 August 2025Author links open overlay panelSection snippetsData availabilityNo new data were created or ...
Enzyme Replacement Therapy in Cholesteryl Ester Storage Disease: A Case Report on Lysosomal Acid Lipase Deficiency Management
Lysosomal Acid Lipase Deficiency (LAL-D) comprises a spectrum of rare autosomal recessive lipid storage disorders, includi...
Human monocyte inflammation in patients with Lp(a) or atherosclerotic cardiovascular disease is not accompanied by changes in chromatin accessibility in circulating classical monocytes
Available online 10 August 2025Author links open overlay panel, , , , , , , , , , , Highlights•High plasma Lp(a) levels ar...
CARDIOMETABOLIC RISK IN PSEUDO-HYPERTRIGLYCERIDEMIA RESULTING FROM HYPERGLYCEROLEMIA
Background and aimsHyperglycerolemia is a rare X-linked inborn error of metabolism whose prevalence is currently unknown. ...
Extreme Lipoprotein (a) is a Cardiovascular Risk Equivalent in Heterozygous Familial Hypercholesterolemia
A.B. received research grants from Akcea, Amgen, Astra Zeneca, Fondation Leducq, Fondation Yvan Morin, Merck Frosst, and S...
Simulation model to estimate pretreatment (baseline) low-density lipoprotein cholesterol levels in people living with homozygous familial hypercholesterolemia
Available online 19 August 2025Author links open overlay panel, , , , , , , AbstractPretreatment levels of low-density lip...
Prevalence, Incidence, and Definition of Severe Hypertriglyceridemia: A Comprehensive Review and Weighted Summary
Available online 20 August 2025Author links open overlay panel, , , , , Highlights•Guidelines and studies lack consensus g...
Statin Use in ATTR Cardiac Amyloidosis: Assessing Tolerability and Drug Interaction Risks with Tafamidis
Transthyretin (ATTR) cardiac amyloidosis is a progressive infiltrative cardiomyopathy caused by the extracellular depositi...
An Indian Adapted Mediterranean Diet: A feasibility study
Archna Singh: Writing – review & editing, Writing – original draft, Supervision, Project administration, Methodology, ...
Non-HDL and LDL cholesterol, but not calculated remnant cholesterol, are associated with subclinical atherosclerosis
Available online 21 August 2025Author links open overlay panel, , , , , , , , Highlights•LDL and non-HDL were independentl...
Greater Alterations in Atherogenic Lipids and Inflammatory Markers in Women during Type 2 Diabetes Development and Risk of Coronary Heart Disease – Findings from Two Population-Based Studies
BackgroundDiabetes confers a greater risk of coronary heart disease (CHD) in women than in men, potentially due to women’s...
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