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The m6A demethylase FTO controls Th1 differentiation and immunity against infections
CD4+ T cells represent a critical component of the adaptive immune system and are essential for defense against viral, fun...
Total free lipids from MDR strain of Mycobacterium tuberculosis “M” reduce T cell activation and CTL activity in healthy individuals
Tuberculosis (TB) continues to be the leading cause of death worldwide from a single infectious agent, with an estimated 7...
Clinical characteristics and outcomes of pediatric anterior and intermediate uveitis in China
Pediatric uveitis is relatively uncommon, representing 5–16 % of all uveitis cases in most tertiary care centers worldwide...
TSPAN15 enhances EMT-mediated metastasis of HCC by promoting autophagy through BTRC-mediated PDCD4 degradation
According to the World Health Organization, it is estimated that more than 1 million patients will die of hepatocellular c...
NLRP3 regulates macrophage function by M-CSF/M-CSFR signaling in acute radiation-induced lung injury
Radiation-induced lung injury (RILI) is the most common and major complication of chest radiotherapy, including radiation ...
LncRNA SNHG12 promotes EMT and metastasis of colorectal cancer via regulating TGF-β/Smad2/3 signaling pathway
ObjectiveIn this study, we aimed to explore the molecular mechanism of SNHG12 promoting colorectal cancer (CRC) progressio...
Helicobacter pylori delays neutrophil apoptosis but also drives the formation of cells with a leaky plasma membrane: Implications for inflammation
Opisthorchis viverrini (OV) infection is a major public health problem in South East Asia and is endemic in the Lower Meko...
Indications of trained innate immunity by Escherichia coli vaccination or chitin feed supplementation assessed during Ascaridia galli infection in chickens
Infections with the gastrointestinal roundworm Ascaridia galli, cause health problems and economic losses in laying hen hu...
Comparative transcriptomic analyses of macrophages infected with Toxoplasma gondii strains of different virulence provide molecular insights into the response of macrophage in phagocytosis and polarization to infection
Macrophages are essential for the proliferation and spread of Toxoplasma gondii. Modulating macrophage activation to impro...
Differences in complement activation of serum-resistant and serum-sensitive Klebsiella pneumoniae isolates
The genetically heterogeneous opportunistic gram-negative bacteria Klebsiella pneumoniae are a common cause of sepsis and ...
Using novel approaches to conjugate peptides of Macrotermes bellicosus and Curcuma longa for targeted intervention of irritable bowl diseases caused by tumor necrosis factor superfamily member 15 (TNFSF15)
Irritable Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, remains a challenging condition linked...
Proteome-wide reverse vaccinology to identify potential vaccine candidates against Staphylococcus aureus
Staphylococcus aureus (S. aureus), a Gram-positive facultative anaerobic bacterium, has the potential to become a highly v...
Andrographolide and its sulfated metabolite alleviated DSS-induced inflammatory bowel disease through regulating inflammation and immune via MAPK/NLRP3 pathways and the balance of Th17/Treg cells
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), constitutes a range of ch...
SAA1 deletion ameliorates cardiac injury after myocardial infarction by promoting macrophage transformation to reparative subtype
Among the various factors leading to fatalities from cardiovascular diseases, acute myocardial infarction (AMI) stands as ...
CRISPR-Cas9 engineering of human T regulatory cells – Design and optimization of a manufacturing process
Regulatory T cells (Tregs) are a subset of CD4 + T cells that comprise 5–10 % of the total CD4 + T cell population. Tregs,...
Psoralidin induces pyroptosis in both tumor cells and macrophages as well as enhances nature killer cell cytotoxicity to suppress hepatocellular carcinoma
Psoralidin is a major component of the traditional Chinese medicine Psoraleae Fructus, which is derived from the dried mat...
NSUN3-mediated m5C modification of TAK1 promotes sepsis-induced pulmonary injury through regulating inflammation
Sepsis-induced pulmonary injury (SPI), also referred to as sepsis-associated acute lung injury (ALI), is a severe complica...
Trogocytosis-mediated acquisition of MHC class II molecules from plasmacytoid dendritic cells confers donor-specific immune tolerance to CD8+CD45RClow/- regulatory T cells
Extensive evidence supports the pivotal role of CD8+Tregs in transplantation and immunological disorders (Yao et al., 2017...
DNA vaccination combined with immune checkpoint inhibition eradicates tumors, inducing life-long immunity against breast cancer in mice
Allan Noé Domínguez-Romero: Visualization, Methodology, Formal analysis, Data curation, Conceptualization. Karen Manoutcha...
Klotho promotes bone formation in rheumatoid arthritis-associated osteoporosis by modulating the Fgf23/Fgfr1/NF-κB pathway and inhibiting ferroptosis
AimsRheumatoid arthritis (RA) frequently leads to osteoporosis (OP) and increased fracture risk. The protein Klotho plays ...
Investigating the role of elastin and extracellular matrix damage in cardiovascular calcification
Cardiovascular calcification is an integral part of many cardiovascular diseases, which collectively are the leading cause...
RosettaHDX: Predicting antibody-antigen interaction from hydrogen-deuterium exchange mass spectrometry data
KeywordsHydrogen–deuterium exchange mass spectrometry (HDX-MS)1Antibody-antigen interaction2Epitope-paratope identificatio...
Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA
Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromol...
A non-parametric approach to particle picking in all frames
Single-particle cryo-electron microscopy (cryo-EM) is a leading technique for determining the three-dimensional structure ...
Mechanistic insights into cyclodextrins as substrates and inhibitors of GH57 family amylopullulanase from Aquifex aeolicus
MOs, defined as starch-derived oligosaccharides containing 3–10 glucose units connected by α-(1–4) glycosidic linkages (Yi...
Three-dimensional reconstruction of Magnetofaba australis strain IT-1: Magnetosome chain position with respect to flagella
Magnetotactic bacteria (MTB) form a distinct group encompassing morphologically, phylogenetically, and physiologically dif...
Effects of Gα C-terminal deletion on the intrinsic GDP release/GTPase activity and conformational dynamics
Heterotrimeric G proteins (G proteins) are pivotal regulators of cellular signaling pathways and operate downstream of G p...
Improving CryoEM maps of symmetry-mismatched macromolecular assemblies: A case study on the flagellar motor
Updated maps and coordinates replace those associated with Singh et al., 2024; the previously reported coordinates should ...
Allosteric inhibition of cytosolic NADP+-dependent isocitrate dehydrogenase by oxaloacetate
Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, following the rea...
Conformational landscape of the mycobacterial inosine 5′-monophosphate dehydrogenase octamerization interface
Atomic coordinates are deposited in the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) ...
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