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Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs following 4 weeks of daily dermal administration
Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, ...
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from and
Evaluation of acute, 28-day, 13-week repeated dose oral toxicity and genotoxicity of a herbal extract (HemoHIM G) from and
HemoHIM G is a functional food ingredient composed of a triple herbal combination of Angelica sinensis, Ligusticum chuanxi...
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from
Evaluation of acute, repeated dose 28-day and 13-week oral toxicity and genotoxicity of a standardized fraction (HemoHIM) from
HemoHIM is a functional food ingredient comprising a triple herbal combination of extracts from Angelica gigas Nakai, Cnid...
Toxicity assessment using neural organoids: innovative approaches and challenges
Toxicity assessment using neural organoids: innovative approaches and challenges
Assessment of toxicity and efficacy in the nervous system is essential to ensure the safety of compounds and the efficacy ...
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019–2020
Chlorobenzylidenemalononitrile (CS) and Oleoresin Capsicum (OC) were tear gasses used as anti-riot control agents during s...
Advancing hepatotoxicity assessment: current advances and future directions
Advancing hepatotoxicity assessment: current advances and future directions
During drug development, it is crucial to ensure that a drug exhibits effective activity in its target cells and organs. H...
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study
Effect of red yeast rice on the growth of male SD rats: a 90-day feeding study
Red yeast rice (RYR) is commonly used as colouring and flavouring agent in foods throughout East Asia. RYR contains monaco...
Human health risks of heavy metals contamination of a water-soil-vegetables farmland system in Toke Kutaye of West Shewa, Ethiopia
Contamination of foods with heavy metals poses significant threats to human health. In this study, human health risks of h...
The rs140668532 SNP in GSK-3β gene as a potential biomarker for Alzheimer’s disease: Insights from computational modeling
Glycogen synthase kinase-3 beta (GSK-3β) is well recognized for its role in diverse physiological processes, including apo...
Drugs or dissection? Unraveling a diagnostic puzzle in the ED: A case report on Tizanidine-Nifedipine interaction
Lower back pain is among the top ten reasons patients visit the emergency department (ED). Tizanidine, a centrally acting ...
Assembled human microbiome and metabolome in chronic kidney disease: Dysbiosis a double-edged sword interlinking Circ-YAP1, Circ-APOE & Circ-SLC8A1
Dysbiosis is an alteration in microbiota diversity previously elucidated in patients with chronic kidney disease (CKD). Re...
Unveiling the molecular interactions between bisphenol A and the cell surface Toll-like receptors: Implications for immune health
Microplastic pollution is an emerging threat to the human health. In nature, microplastics release several compounds of to...
Naringin ameliorates high-fat diet-induced hepatotoxicity and dyslipidemia in experimental rat model via modulation of anti-oxidant enzymes, AMPK and SERBP-1c signaling pathways
High-fat diet causes elevation of steatosis, dyslipidemia and oxidative stress which eventually leads to hepatic injury in...
Analysis of pesticide residues in tomatoes from the tomato field and markets of KPK, Pakistan and their potential risk to human health
The study was designed to get a real time picture of pesticide residues in tomato samples from the fields of two districts...
Ferroptotic- and non-ferroptotic mechanisms associated with doxorubicin-induced male reproductive dysfunction
Despite the effectiveness of doxorubicin as a chemotherapeutic agent, it exerts toxicity on non-target organs, including t...
The effects of methamphetamine intoxication on acute kidney injury in Iraqi male addicts
Methamphetamine (METH), a synthetic derivative of amphetamine, is prescribed for disorders such as narcolepsy but is somet...
Sub-acute polyethylene microplastic inhalation exposure induced pulmonary toxicity in wistar rats through inflammation and oxidative stress
Plastic waste, particularly polyethylene (PE) plastic bags and bottles, poses a significant environmental problem and heal...
Genotoxic activity of glyphosate and co-formulants in glyphosate-based herbicides assessed by the micronucleus test in human mononuclear white blood cells
Glyphosate-based herbicides (GBHs) are widely used and contribute to soil, water, and air contamination. Despite differing...
Occurrence and dietary risk assessment of chloramphenicol residues in honey products in Saudi Arabia
BackgroundChloramphenicol (CAP) is a broad-spectrum antibiotic with potentially fatal side effects, including suspected ca...
Corrigendum to “Insights into medication-induced liver injury: Understanding and management strategies” [Toxicol. Rep. 14 (2025) 101976]
Volume 14, June 2025, 102068Author links open overlay panelVatsalya Tiwari a, Shrishti Shandily a, Jessielina Albert a, Va...
Editorial: Special issue on Current developments in immunotherapy and related toxicities
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Berberine nanoemulsion attenuates bisphenol A-induced metabolic impairment through NF-κB signaling in the liver of rat
This study was designed to investigate the potential of Berberine nanoemulsion (BNE) to mitigate Bisphenol A (BPA)-induced...
Determination of nitrofuran metabolites in sausage casings and crawfish using LC-Q-Orbitrap HRMS: Method development and validation
This study developed and validated an analytical method for determining four nitrofuran (NF) metabolites in sausage casing...
Per- and polyfluorinated substances (PFAS) promote osteoclastogenesis and bone loss through PPARα activation
Per- and polyfluoroalkyl substances (PFAS) are emerging as significant environmental contaminants affecting bone health, w...
Transgenerational toxicity of Aroclor 1232 by inhalational route in mouse model
BackgroundAroclor 1232 is a commercial mixture of polychlorinated biphenyls with inhalational toxicological implications a...
A review of the sidelined pollutant: Reviving the fight against heavy metal contamination in an era of emerging contaminants
Groundwater contamination by heavy metals (HMs) remains a pressing global concern, presenting substantial risks to humans,...
Pre-treatment red cell index and metastasis status as independent predictors of overall survival in Jordanian breast cancer patients receiving chemotherapy
Breast cancer (BC) poses a global health challenge, necessitating accessible prognostic biomarkers. Systemic inflammatory ...
Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study.
Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study.
medRxiv - The Preprint Server for Health Sciences
Alterations in the plasma metabolome associated with maternal smoking during the first trimester
Alterations in the plasma metabolome associated with maternal smoking during the first trimester
medRxiv - The Preprint Server for Health Sciences
Metabolic alterations in human post-mortem frontal cortex and cerebrospinal fluid associated with high levels of nicotine metabolite cotinine
Metabolic alterations in human post-mortem frontal cortex and cerebrospinal fluid associated with high levels of nicotine metabolite cotinine
medRxiv - The Preprint Server for Health Sciences
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