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Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling
Defining human MC phenotypes in nasal polyposis. To gain deeper insights into the developmental signals directing MC diff...
Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats
Research ArticleOncologyTherapeutics Open Access | 10.1172/JCI181305 Xinxia Zhu,1,2 Russe...
A vaccine against cytomegalovirus: how close are we?
Focusing on platforms that have advanced beyond phase I study, several vaccines have demonstrated varying degrees of prot...
TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa
Mast cells (MCs) are evolutionarily old immune cells, of which humans have 2 largely different types. One is a constituti...
Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium
Review Open Access | 10.1172/JCI183836 James P. Bridges,1,2 Eszter K. Vladar,2 Jonath...
Leptin signaling maintains autonomic stability during severe influenza infection in mice
Research LetterEndocrinologyInfectious disease Open Access | 10.1172/JCI182550 Andrés R. Muño...
Clonal hematopoiesis JAKs up plaque formation
Clonal hematopoiesis (CH) is a condition in which aged hematopoietic stem cells (HSCs) acquire somatic mutations commonly...
A conversation with Zhijian (James) Chen
Zhijian (James) Chen (University of Texas Southwestern and HHMI) has had a storied research career focused on the molecul...
Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma
Research ArticleGeneticsOncology Open Access | 10.1172/JCI182768 Yanni Zeng,1,2,3 Chun-Li...
T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions
Research ArticleDermatologyOncology Open Access | 10.1172/JCI183274 Tomonori Oka,1 Sabrin...
Elevated microRNA-187 causes cardiac endothelial dysplasia to promote congenital heart disease through inhibition of NIPBL
Sex as a biological variable. Our study examined male and female animals, and similar findings are reported for both sexe...
TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis
TREM2 expression is upregulated in monocytes/macrophages and is associated with disease severity in sepsis. Sepsis patien...
Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis
Patients with HTG-AP have high serum TGs, serum NEFAs, and worse clinical outcomes. Between August 2019 and November 2021...
APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer’s disease
Research ArticleAgingNeuroscience Open Access | 10.1172/JCI184656 Qiuyun Tian,1 Junjie Li...
Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring
Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Department of Pe...
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
Research ArticleImmunologyOncology Open Access | 10.1172/JCI181895 Garry Dolton,1 Hannah ...
68Ga-MY6349 PET/CT imaging to assess Trop2 expression in multiple types of cancer
Clinical Research and Public HealthOncology Open Access | 10.1172/JCI185408 Haojun Chen,1,2 ...
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy
Research ArticleCardiology Open Access | 10.1172/JCI181630 Bryan Z. Wang,1 Margaretha A.J...
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Research ArticleVascular biology Open Access | 10.1172/JCI182939 Wenli Liu,1 Brian D. Har...
A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations
Research ArticleImmunologyNeuroscience Open Access | 10.1172/JCI177793 Claudia Cantoni,1 ...
A retrospective cross-sectional study on district-based socioeconomic status and prostate cancer diagnosis
A retrospective cross-sectional study on district-based socioeconomic status and prostate cancer diagnosis
Socioeconomic disparities have been linked to delayed prostate cancer diagnosis and poorer outcomes in various countries. ...
COVID-19 vaccines: anaphylaxis and anxiety
COVID-19 vaccines: anaphylaxis and anxiety
Vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) was one crucial element to overcome ...
Dank an Prof. Peter Pietschmann
Dank an Prof. Peter Pietschmann
Unser Ziel war und ist es, das altehrwürdige Journal nicht nur in der modernen Publikationslandschaft weiterzuführen, sond...
Frühe urologische und venerourologische Quellen zur Sexualmedizin aus Wien
Frühe urologische und venerourologische Quellen zur Sexualmedizin aus Wien
Im Jahre 2014 wurde eine „Österreichische Gesellschaft zur Förderung der Sexualmedizin und der Sexuellen G...
Angular cheilitis—an oral disease with many facets
Angular cheilitis—an oral disease with many facets
Cheilitis is a common inflammatory disorder of the vermillion and adjacent skin of the lips. A special t...
A short story of long COVID
A short story of long COVID
Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV. A clinical case definition of post-COVID-19 condition by a Delphi con...
Facilitators and barriers of long-term exercise adherence in healthcare workers formerly suffering from post-COVID-19 syndrome
Facilitators and barriers of long-term exercise adherence in healthcare workers formerly suffering from post-COVID-19 syndrome
Early exercise intervention studies showed promising positive effects of physical exercising on post-COVID-19 sym...
Relationship between GPS-based community mobility data and orthopedic trauma admissions during the COVID-19 pandemic in Austria: a multicenter analysis
Relationship between GPS-based community mobility data and orthopedic trauma admissions during the COVID-19 pandemic in Austria: a multicenter analysis
The main objective of this study was to examine the relationship between mobility patterns during the coronavirus disease ...
Amyloid-beta antibody treatment in Alzheimer’s disease
Amyloid-beta antibody treatment in Alzheimer’s disease
Amyloid-beta (Aβ) antibody treatment has emerged as a promising approach for the treatment of Alzheimer̵...
Peripheral Lymphocyte-to-Monocyte Ratio as a Predictive Factor for Early Neurological Deterioration in Patients with Acute Ischemic Stroke
Peripheral Lymphocyte-to-Monocyte Ratio as a Predictive Factor for Early Neurological Deterioration in Patients with Acute Ischemic Stroke
Exploring the factors associated with END and evaluating the predictive value of lymphocyte-to-monocyte ratio as a prognos...
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