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Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging
Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging
There is currently no standardized protocol for the measurement of gait speed in older adults, particularly regarding the ...
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis
Despite evidence linking the gut microbiome to neuropathic pain (NP), it is not known if altering gut microbiota can allev...
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The Saliva and Muscle Study (SaMu): Rationale and Protocol for Associations between Salivary Microbiome and Accelerated Muscle Ageing
The gut microbiome is recognized as a pivotal factor in the pathophysiology of sarcopenia—a condition marked by the ...
Utilisation and Outcome of Cranial CT Imaging in Older Adults Attending ED Following a Fall
Utilisation and Outcome of Cranial CT Imaging in Older Adults Attending ED Following a Fall
Healthcare demand from falls in older adults is increasing, but guidance from the literature is lacking on the value of ne...
Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
Objective Measures of Physical Activity and Frailty in Ambulatory Adults Aged 85–89 Years in Kawasaki, Japan: A Cross-sectional Study
While physical activity (PA) can reduce physical frailty, the specific intensity and duration of PA required to prevent fr...
Frailty Index, Not Age, Predicts Treatment Outcomes and Adverse Events for Older Adults with Cancer
Frailty Index, Not Age, Predicts Treatment Outcomes and Adverse Events for Older Adults with Cancer
Frailty is an indicator of individual vulnerability and differentiates health status among people of the same chronologica...
Five-Time Sit-To-Stand Lower Limb Muscle Power in Older Women: An Explorative, Descriptive and Comparative Analysis
Five-Time Sit-To-Stand Lower Limb Muscle Power in Older Women: An Explorative, Descriptive and Comparative Analysis
Muscle power assessment entails the use of complex equipment which impacts its clinical applicability. Recently, equations...
The Efficacy of 12-Week Progressive Home-Based Strength and Tai-Chi Exercise Snacking in Older Adults: A Mixed-Method Exploratory Randomised Control Trial
The Efficacy of 12-Week Progressive Home-Based Strength and Tai-Chi Exercise Snacking in Older Adults: A Mixed-Method Exploratory Randomised Control Trial
Maintaining physical function is important for independence and frailty prevention in later life, but very few older adult...
Exercise Modalities in Multi-Component Interventions for Older adults with Multi-Morbidity: A Systematic Review and Narrative Synthesis
Exercise Modalities in Multi-Component Interventions for Older adults with Multi-Morbidity: A Systematic Review and Narrative Synthesis
Exercise is efficacious in older adults, including those with multi-morbidity. However, the optimum mode is not known and ...
Application of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV
Application of a Social Vulnerability Index and Its Associations with Physical Frailty and Disability in a Cross-sectional Study of Older Kenyan Women Living with and without HIV
Social vulnerability reflects deficits in social resources that may disproportionally impact older women with HIV (WWH) in...
Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials
Polyphenol Supplementation and Sarcopenia: A Systematic Review and Meta-Analysis of Clinical Trials
Experimental evidence suggests that polyphenols, a large group of phytochemicals found in fruits and vegetables, may prese...
Repetitive element transcript accumulation is associated with inflammaging in humans
Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healths...
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons
17α-Estradiol (17αE2), a less-feminising enantiomer of 17β-estradiol, has been shown to prolong lifespan an...
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Exploring the role of microRNAs as diagnostic and prognostic biomarkers in canine mammary tumors
Canine mammary tumors (CMTs) represent a significant health concern in dogs, with a high incidence among intact female dog...
Modulation of neural gene networks by estradiol in old rhesus macaque females
Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol (E2) levels has been shown to contribute to several adverse physiolog...
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats
The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diver...
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
Losartan attenuates sex-dependent hypertension, neuroinflammation, and cognitive impairment in the aging male sprague–dawley rat
The prevalence of hypertension increases with age and is the leading modifiable risk factor for cognitive impairment and d...
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Blood-based biomarkers for early frailty are sex-specific: validation of a combined in silico prediction and data-driven approach
Frailty is characterized by loss of physical function and is preferably diagnosed at an early stage (e.g., during pre-frai...
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty and functional disability in older adults: A 10-year prospective cohort study in Japan
Cognitive frailty is considered a clinical entity associated with a high risk for adverse health outcomes. However, its cl...
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice
Frailty is a complex condition characterized by a decline in multiple physiological systems, compromising an individual...
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells
Fibroblast growth factor 21 (FGF21) is a key regulator of metabolism and cardiovascular health. However, its upregulation ...
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort
The present study explored for the first time the blood-based proteomic signature that could potentially distinguish older...
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates
Age-associated loss of muscle mass and function and subsequent mobility decline define poor health outcomes, reduced quali...
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
A multi-stage feature selection method to improve classification of potential super-agers and cognitive decliners using structural brain MRI data—a UK biobank study
Cognitive aging is described as the age-related decline in areas such as memory, executive function, reasoning, and proces...
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
Many aspects of inflammation increase with aging in mice and humans. Transcriptomic analysis revealed that many murine ant...
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice
Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive ...
A complex systems approach to mosaic loss of the Y chromosome
A complex systems approach to mosaic loss of the Y chromosome
Mosaic loss of Y chromosome (mLOY) is an acquired condition wherein a sizeable proportion of an organ’s cells have l...
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
The effectiveness of digital technology interventions for cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials
Digital technology interventions (DTIs) are seen as promising interventions to prevent or delay cognitive decline in older...
Bibliometric Analysis of Social Support for the Older Adults
Bibliometric Analysis of Social Support for the Older Adults
This bibliometric analysis endeavors to bridge a gap in existing research on social support for the older adults, focusing...
Factors Affecting Hypertension among Middle and Old Aged People in Northern Region of India: A Cross-Sectional Study Using LASI Wave-1 Data
Factors Affecting Hypertension among Middle and Old Aged People in Northern Region of India: A Cross-Sectional Study Using LASI Wave-1 Data
Globally, hypertension among mid & old aged population is considered a severe chronic health issue. The latest LAS...
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