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Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increas...
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential
In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (S...
Ageing and dysregulated lung immune responses in fatal COVID-19
Ageing and dysregulated lung immune responses in fatal COVID-19
Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19...
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling
The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plastic...
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
Muscle Strength Matters Most for Risk of Falling Apart from Body Mass Index in Older Adults: A Mediated-Moderation Analysis
The primary objective of this study was to analyze the moderating effect of body mass index (BMI) on the association betwe...
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
The Relationship between Leisure Time Physical Activity and Cognitive Function in Older Americans
This study aims to investigate the correlation between leisure-time physical activity (LTPA) and cognitive function in old...
Exploring the Role of Antibiotics in Hospice Care
Exploring the Role of Antibiotics in Hospice Care
The decision regarding the use of antibiotics in hospice care, whether to initiate, defer, or discontinue therapy, present...
Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization
Identification of gut microbiota causally associated with aging and longevity and mediation roles of the cerebrospinal fluid proteins: proteomic genetic evidence from Mendelian randomization
Gut microbiota (GM) is implicated in aging biology, yet its dual regulatory role in the distinct yet interconnected proces...
Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach
Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach
Delirium is a severe and common complication among critically ill patients, particularly those with SARS-CoV-2 infection, ...
Associations of accelerated epigenetic aging with cancer and mortality risk in the USA
Associations of accelerated epigenetic aging with cancer and mortality risk in the USA
DNA methylation (DNAm) algorithms have been developed to assess biological aging and its association with cancer. Despite ...
Psychological predictors of gerascophobia among middle-aged and older adults: the role of health anxiety and body image satisfaction
Psychological predictors of gerascophobia among middle-aged and older adults: the role of health anxiety and body image satisfaction
Gerascophobia—the excessive fear of aging—is linked to health anxiety and negative body perceptions. While hea...
A proper combination of movement and stillness: the interaction effect of sleep duration and physical activity on longitudinal cognitive performance in Chinese middle-aged and older adults
A proper combination of movement and stillness: the interaction effect of sleep duration and physical activity on longitudinal cognitive performance in Chinese middle-aged and older adults
Previous studies have shown that both nighttime sleep duration (NSD) and physical activity (PA) are independently associat...
Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis
Liver injury severity determines skeletal deterioration: a shared pathophysiological axis between MASLD and osteoarthritis
Nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) have been linked to osteoporosis and osteoarthritis...
Design and test–retest reliability of a new test to assess motor competence in healthy older adults
Design and test–retest reliability of a new test to assess motor competence in healthy older adults
The objective of this study was to design and analyze the test–retest reliability of a test to assess holistic motor...
Alterations in mitochondria and cellular senescence in aged sEH null female kidneys
Alterations in mitochondria and cellular senescence in aged sEH null female kidneys
Age-related structural and functional deterioration of the kidneys is common among elderly individuals and contributes to ...
Cellular senescence—from solid organs to vascularized composite allotransplants
Cellular senescence—from solid organs to vascularized composite allotransplants
Vascularized composite allotransplantation (VCA) has emerged as a novel therapy approach to restore form and function in p...
Dual-channel mechanism of groove music fused with Tai Chi to improve cognitive-emotional abilities in older adults based on a coupled fNIRS-EMG analysis: a randomized controlled study
Dual-channel mechanism of groove music fused with Tai Chi to improve cognitive-emotional abilities in older adults based on a coupled fNIRS-EMG analysis: a randomized controlled study
This study aimed to investigate the dual-pathway mechanisms underlying cognitive-emotional integration in older adults thr...
Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis
Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis
Reduced peak oxygen uptake (V̇O₂peak) is a hallmark of heart failure (HF) and aging, but studies on V̇O...
Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank
Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank
Ultra-processed foods (UPF) are increasingly linked to negative health outcomes, including chronic diseases and mortality....
Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson’s disease progression
Task-specific dynamical entropy variations in EEG as a biomarker for Parkinson’s disease progression
Uncovering the neuronal mechanisms un-derlying optimal behavioral performance is essential to understand how the brain dyn...
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
From the plate to the brain: associations between dietary patterns and reduced dementia prevalence and white matter lesions in older Japanese adults
Diet is widely considered essential in dementia, but its association with white matter lesions (WMLs) remains unclear. Thi...
Health-related quality of life trajectories and loss of independence among community-dwelling older adults
Health-related quality of life trajectories and loss of independence among community-dwelling older adults
Health-related quality of life (HRQOL) is a key determinant of loss of independence (LOI) among older adults. However, the...
A simple blood biomarker based on gene expression describes cardiovascular health-related biological age
A simple blood biomarker based on gene expression describes cardiovascular health-related biological age
The need to monitor the aging process as a risk factor for disease and mortality beyond chronological age (CA) has led to ...
Methylation array signals are predictive of chronological age without bisulfite conversion
Methylation array signals are predictive of chronological age without bisulfite conversion
DNA methylation data has been used to make “epigenetic clocks” which attempt to measure chronological and biol...
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats
High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats
Aging is associated with metabolic decline in the brain, increasing susceptibility to neurodegenerative diseases. While ex...
Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial
Comparison of the acute effects of breaking up prolonged sitting time with single-task or a dual-task walking on cognitive function and cerebral blood flow in older adults: a randomized crossover trial
This randomized cross-over study examined the acute effects of single-task or dual-task walking physical activity (PA) bre...
Treatment of age-related decreases in GTP levels restores endocytosis and autophagy
Treatment of age-related decreases in GTP levels restores endocytosis and autophagy
Age-related declines in neuronal bioenergetic levels may limit vesicular trafficking and autophagic clearance of damaged o...
Prevalence and natural course of incidental gastric subepithelial tumors
Table 1. Comparison of baseline demographics and clinical characteristics between the stable gastric and pro...
Jejunal Dieulafoy
Fig. 1. Push enteroscopy reveals a 2.5 cm round subepithelial mass with a large central defect covered ...
Safety and efficacy of novel oblique-viewing scope for B2-endoscopic ultrasound-guided ...
Fig. 1. Flowchart of patient selection. B2, bile duct segment 2; EUS-HGS, endoscopic ultrasound-guided ...
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