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Antilung cancer activity and apoptosis mechanisms of imidazolyl acylhydrazone zinc and europium complexes with chain structures
Cancer incidence and mortality are rising; projections estimate 35 million new global cases by 2050 [1]. Currently, the ma...
Heme and CO metabolism by the canonical human heme oxygenases
Heme is an essential biomolecule and cofactor that participates in many different biological processes by binding to a div...
Half-sandwich ruthenium (II) complexes with N,O-Quinoxaline ligand: Synthesis, in silico affinity and Mycobacterium tuberculosis susceptibility
Tuberculosis (TB) remains one of the deadliest bacterial infections, despite the approval of new anti-bacterial drugs over...
The cytochrome P450 decarboxylase from Staphylococcus aureus can produce a diene from a C18 monounsaturated fatty acid: A spectroscopic, structural and kinetic characterisation
Volume 275, February 2026, 113117Author links open overlay panel, , , , , Highlights•OleTSa is co-purified with a monounsa...
Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions
Heme is a cofactor essential for a multitude of biological reactions. The terminal step of heme synthesis occurs in the mi...
Oxidizable amino acids around cytochrome P450 hemes
Cytochrome P450 enzymes (also designated with the prefix CYP) catalyze oxygenation reactions on a wide array of organic su...
P450 Electron transfer: Towards in vitro NAD(P)H-independent biocatalysis
The activation of C-H bonds is of significant interest given its many applications, such as conversion of methane to metha...
Hydroxy-substituted electron deficient Pd porphyrin cofactors illuminate ultrafast proton transfer reactions
Volume 275, February 2026, 113116Author links open overlay panel, , , , , , , Highlights•pKa of chromophoric photoacid PPd...
Iron(III) complexes of tridentate (NNO) ligands: Efficient catalysts for the synthesis of aminophenoxazinones in aqueous medium
The design and investigation of transition metal complexes incorporating distinct ligand scaffolds is of immense significa...
Infection-adaptive regenerative wound healing through rationally engineered copper-polyphenol artificial enzymes enabling quadruple-modal ROS cascade modulation in pathological microenvironments
Volume 275, February 2026, 113132Author links open overlay panel, , , , , , , , , , Highlights•Synthetic polyphenols with ...
Proton coupled electron transfer in myoglobin compound II auto-reduction revealed by temperature dependent rate behavior
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
Volume 275, February 2026, 113130Author links open overlay panel, , , , , , , , , , , , , Highlights•Monocarboxylate Trans...
Novel cationic gold(I) compounds with 5-nitrofuryl containing thiosemicarbazone ligands exhibit activity against Trypanosoma cruzi
Volume 275, February 2026, 113131Author links open overlay panel, , , , , , , , Highlights•First novel cationic gold(I)-th...
Investigations of gold(I) complexes as inhibitors of caspase-1
Volume 275, February 2026, 113133Author links open overlay panel, , , , , , , Highlights•Gold(I) inhibits caspase-1•DFT ca...
Antineoplastic and antibacterial activity of new copper(II) complexes with H₂salbu and H₄salbu Schiff base-type ligands
AbstractThis study explores the structural, electronic, and biological properties of ten copper(II) complexes with Schiff ...
Oleoyl coenzyme A triggers peroxygenase activity in cytochrome c
The oxidation of cardiolipin by cytochrome c (cyt c) plays a crucial role in cyt c release from mitochondria at the initia...
Examining Pseudohalide (N3, NCS, NCO) Coordination in Nonheme Fe(II) and Fe(III) Complexes
Pseudohalide ligands (N3−, NCS−, NCO−) have emerged as valuable probes for studying nonheme iron halogenase reactivity due...
Synthesis, structure, and anticancer activity of Ni(II) complexes derived from polyhalogenated 2-aminophenol Schiff bases
Since the widespread clinical application of cisplatin as an anticancer drug, bioinorganic chemistry has advanced signific...
Copper(II) and zinc(II) complexes of dimeric 8-hydroxyquinoline ligands: Synthesis, metal speciation, and biological evaluation
Hydroxyquinolines have garnered considerable attention due to their biomedical potential, particularly their ability to co...
Efficient photodynamic and photocatalytic anticancer activity of a Ru(II) polypyridyl complex
Photodynamic therapy (PDT) is a promising cancer treatment modality that leverages photoactivatable prodrugs. It works by ...
Genetic innovations underlying the evolution of root nodule symbiosis in Leguminosae
Available online 30 September 2025Author links open overlay panel, , ABSTRACTRoot nodule symbiosis (RNS) is a mutualistic ...
Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review
Amyotrophic lateral sclerosis (ALS) was initially described as a pure motor neuron disorder in 1869 by the eminent French ...
Postnatal critical-period brain plasticity and neurodevelopmental disorders: revisited circuit mechanisms
Volume 52, Issue 10, October 2025, Pages 1177-1188Author links open overlay panel, AbstractCritical periods (CPs) are defi...
Biallelic MED16 variants disrupt neural development and lead to an intellectual disability syndrome
MED16 (MIM: 604062) is a subunit of the Mediator (MED) complex, which processes and transduces regulatory signals from gen...
Diverse functions of sex determination gene doublesex on sexually dimorphic neuronal development and behaviors
Volume 52, Issue 10, October 2025, Pages 1199-1210Author links open overlay panel, , , , , , , , AbstractSex-specific neur...
Coordinated regulation of cortical astrocyte maturation by OLIG1 and OLIG2 through BMP7 signaling modulation
Volume 52, Issue 10, October 2025, Pages 1224-1237Author links open overlay panel, , , , , , , , , , , , , , , , AbstractA...
Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes
The gut microbiota has been reported to be involved in a variety of physiological processes, including digestion, immunity...
Massively parallel characterization of non-coding de novo mutations in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication and ...
Rapamycin alleviates neurodegeneration in a Drosophila model of spinocerebellar ataxia type 51
Volume 52, Issue 10, October 2025, Pages 1259-1267Author links open overlay panel, , , , , , , , , , AbstractSpinocerebell...
ATPase-deficient CHD7 disease variant disrupts neural development via chromatin dysregulation
ATP-dependent chromatin remodelers utilize the energy from ATP hydrolysis to reposition or evict nucleosomes, a process es...
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