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Antilung cancer activity and apoptosis mechanisms of imidazolyl acylhydrazone zinc and europium complexes with chain structures
Cancer incidence and mortality are rising; projections estimate 35 million new global cases by 2050 [1]. Currently, the ma...
Heme and CO metabolism by the canonical human heme oxygenases
Heme is an essential biomolecule and cofactor that participates in many different biological processes by binding to a div...
Half-sandwich ruthenium (II) complexes with N,O-Quinoxaline ligand: Synthesis, in silico affinity and Mycobacterium tuberculosis susceptibility
Tuberculosis (TB) remains one of the deadliest bacterial infections, despite the approval of new anti-bacterial drugs over...
The cytochrome P450 decarboxylase from Staphylococcus aureus can produce a diene from a C18 monounsaturated fatty acid: A spectroscopic, structural and kinetic characterisation
Volume 275, February 2026, 113117Author links open overlay panel, , , , , Highlights•OleTSa is co-purified with a monounsa...
Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions
Heme is a cofactor essential for a multitude of biological reactions. The terminal step of heme synthesis occurs in the mi...
Oxidizable amino acids around cytochrome P450 hemes
Cytochrome P450 enzymes (also designated with the prefix CYP) catalyze oxygenation reactions on a wide array of organic su...
P450 Electron transfer: Towards in vitro NAD(P)H-independent biocatalysis
The activation of C-H bonds is of significant interest given its many applications, such as conversion of methane to metha...
Hydroxy-substituted electron deficient Pd porphyrin cofactors illuminate ultrafast proton transfer reactions
Volume 275, February 2026, 113116Author links open overlay panel, , , , , , , Highlights•pKa of chromophoric photoacid PPd...
Iron(III) complexes of tridentate (NNO) ligands: Efficient catalysts for the synthesis of aminophenoxazinones in aqueous medium
The design and investigation of transition metal complexes incorporating distinct ligand scaffolds is of immense significa...
Infection-adaptive regenerative wound healing through rationally engineered copper-polyphenol artificial enzymes enabling quadruple-modal ROS cascade modulation in pathological microenvironments
Volume 275, February 2026, 113132Author links open overlay panel, , , , , , , , , , Highlights•Synthetic polyphenols with ...
Proton coupled electron transfer in myoglobin compound II auto-reduction revealed by temperature dependent rate behavior
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
Volume 275, February 2026, 113130Author links open overlay panel, , , , , , , , , , , , , Highlights•Monocarboxylate Trans...
Novel cationic gold(I) compounds with 5-nitrofuryl containing thiosemicarbazone ligands exhibit activity against Trypanosoma cruzi
Volume 275, February 2026, 113131Author links open overlay panel, , , , , , , , Highlights•First novel cationic gold(I)-th...
Investigations of gold(I) complexes as inhibitors of caspase-1
Volume 275, February 2026, 113133Author links open overlay panel, , , , , , , Highlights•Gold(I) inhibits caspase-1•DFT ca...
Antineoplastic and antibacterial activity of new copper(II) complexes with H₂salbu and H₄salbu Schiff base-type ligands
AbstractThis study explores the structural, electronic, and biological properties of ten copper(II) complexes with Schiff ...
Oleoyl coenzyme A triggers peroxygenase activity in cytochrome c
The oxidation of cardiolipin by cytochrome c (cyt c) plays a crucial role in cyt c release from mitochondria at the initia...
Examining Pseudohalide (N3, NCS, NCO) Coordination in Nonheme Fe(II) and Fe(III) Complexes
Pseudohalide ligands (N3−, NCS−, NCO−) have emerged as valuable probes for studying nonheme iron halogenase reactivity due...
Synthesis, structure, and anticancer activity of Ni(II) complexes derived from polyhalogenated 2-aminophenol Schiff bases
Since the widespread clinical application of cisplatin as an anticancer drug, bioinorganic chemistry has advanced signific...
Copper(II) and zinc(II) complexes of dimeric 8-hydroxyquinoline ligands: Synthesis, metal speciation, and biological evaluation
Hydroxyquinolines have garnered considerable attention due to their biomedical potential, particularly their ability to co...
Efficient photodynamic and photocatalytic anticancer activity of a Ru(II) polypyridyl complex
Photodynamic therapy (PDT) is a promising cancer treatment modality that leverages photoactivatable prodrugs. It works by ...
Resveratrol derivative modified Ru(II) complexes: Synthesis, characterization, in vitro and in vivo anticancer study
As the fourth highest lethal cancer, colorectal cancer (CRC) has become one of the most challenging diseases. The incidenc...
Probing the generation, reactivity, and kinetics of high-valent manganese-oxo phthalocyanines: Insights into oxidation mechanisms
Catalytic oxidations of organic compounds with atom-efficient, inexpensive, and readily available oxygen sources are widel...
Mechanistic insights into Staphylococcus aureus IsdG-Ferrochelatase interactions: A key to understanding haem homeostasis in pathogens
In this study, we explore the molecular interactions between two Staphylococcus aureus enzymes, the haem oxygenase IsdG an...
Heme dependent activity of the Streptomyces c-di-GMP-metabolizing enzyme CdgA
Streptomyces species are vital for producing natural products like antibiotics, with c-di-GMP playing a key role in regula...
An efficient circularly polarized luminescence probe base on anthryl-modified Eu(III)-helicates for the detection and imaging singlet oxygen in living cells
Singlet oxygen (1O2) is an important reactive oxygen species in the lowest excited state, playing a crucial role in variou...
Gaseous ligand binding to Porphyromonas gingivalis HmuY hemophore-like protein in complex with heme
* Synopsis for the Graphical Abstract - 50 words max, NO UNDEFINED ABBREVIATIONS – below is my suggestionGaseous ligands (...
Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells
Provisional Statement: Crystallographic data for compound 1 was deposited at the CCDC database under the accession number ...
Pyridine alcohols: New applications reviving interest in metal complexes of a classical ligand
Ligands have a major impact on applications of the resulting complexes, so their design is crucial in coordination chemist...
Online OCHEM multi-task model for solubility and lipophilicity prediction of platinum complexes
Volume 269, August 2025, 112890Author links open overlay panel, , , , , , , , , Highlights•First online model to predict w...
Identification of Ni2+-binding peptides in sunflower meal protein hydrolysate for deeper understanding of peptide-metal interactions
Sunflower (Helianthus annus L.) is one of the most important oil crops in the world. Once oil extracted, sunflower meal by...
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