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Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation
In a recent publication published in Cell, Tamari et al. unraveled a previously unrecognized role of ...
DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease
DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoki...
Targeted therapy for capillary-venous malformations
Targeted therapy for capillary-venous malformations
Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TE...
Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity,...
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial...
Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection
Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (H...
From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake
From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake
In a study published in Cell, Hu and colleagues discovered that the signaling activity of the intesti...
Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer
Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer
Pancreatic cancer is one of the deadly malignancies with a significant mortality rate and there are currently few therapeu...
A novel alternative for pyrogen detection based on a transgenic cell line
A novel alternative for pyrogen detection based on a transgenic cell line
Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologi...
TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway
Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen and significantly associate...
Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA
Targeted drug approvals in 2023: breakthroughs by the FDA and NMPA
According to the official website of China’s National Medicines and Pharmaceutical Administration (NM...
Gut microbiome regulates inflammation and insulin resistance: a novel therapeutic target to improve insulin sensitivity
Gut microbiome regulates inflammation and insulin resistance: a novel therapeutic target to improve insulin sensitivity
In a recent study published in Nature, Takeuchi et al. used a multi-omics strategy in humans to provi...
Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment
Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment
Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which ...
Feeding the vasculature with cruciferous vegetables: a secret for organ protection
Feeding the vasculature with cruciferous vegetables: a secret for organ protection
Two very recent back-to-back papers published in Nature1,2 decipher the holistic role of the aryl hyd...
Protein translation: biological processes and therapeutic strategies for human diseases
Protein translation: biological processes and therapeutic strategies for human diseases
Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. T...
Precise genome-editing in human diseases: mechanisms, strategies and applications
Precise genome-editing in human diseases: mechanisms, strategies and applications
Precise genome-editing platforms are versatile tools for generating specific, site-directed DNA insertions, deletions, and...
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
Managing type 2 diabetes: targeting a microbial enzyme as a novel treatment option
In a recent Science article, Wang and colleagues showed that the dipeptidyl peptidase 4 (DPP4) enzyme...
IgE-Mast cell mediated allergy: a sensor of food quality
IgE-Mast cell mediated allergy: a sensor of food quality
In two recent studies published in Nature, Florsheim et al. and Plum et al. reported that allergic-sp...
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, ...
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other cell death modes, p...
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy
In a recent article published in Cancer Discovery, Guirguis et al. demonstrated that enzymatic inhibi...
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
Tau in the pancreas: understanding the link between type 2 diabetes mellitus and Alzheimer’s disease
A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to...
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study
This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and niv...
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut liver brain axis in diseases: the implications for therapeutic interventions
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and...
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets
The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for three years, yet the diagnostic and treatme...
Going only half the way: cell cycle exit after the G1 restriction point
Going only half the way: cell cycle exit after the G1 restriction point
In a recent article published in Nature, James A. Cornwell et al. describe that cyclin A2 levels dete...
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
In recent studies published in Nature and Lancet Infectious Diseases,1,2 SARS-CoV-2 Omicron subvarian...
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy
Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of p...
γδ T cells: origin and fate, subsets, diseases and immunotherapy
γδ T cells: origin and fate, subsets, diseases and immunotherapy
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the...
Multifunctional mesoporous silica nanoparticles for biomedical applications
Multifunctional mesoporous silica nanoparticles for biomedical applications
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field...
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