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Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells
Life-long functional regeneration of in vivo airway epithelium by the engraftment of airway basal stem cells
Durable and functional regeneration of the airway epithelium in vivo with transplanted stem cells has the potential to rec...
Using the Chemotion repository to deposit and access FAIR research data for chemistry experiments
Using the Chemotion repository to deposit and access FAIR research data for chemistry experiments
We are thankful for the support of the Ministry of Science, Research and the Arts of Baden-Württemberg (MWK Baden-Württemb...
Rapid parallel reconstruction and specificity screening of hundreds of T cell receptors
Rapid parallel reconstruction and specificity screening of hundreds of T cell receptors
The ability to screen the reactivity of T cell receptors (TCRs) is essential to understanding how antigen-specific T cells...
Versatile synthesis of uniform mesoporous superparticles from stable monomicelle units
Versatile synthesis of uniform mesoporous superparticles from stable monomicelle units
Superstructures with architectural complexity and unique functionalities are promising for a variety of practical applicat...
High-throughput glycosaminoglycan extraction and UHPLC-MS/MS quantification in human biofluids
High-throughput glycosaminoglycan extraction and UHPLC-MS/MS quantification in human biofluids
Glycosaminoglycans (GAGs) are linear, unbranched heteropolysaccharides whose structural complexity determines their functi...
RNA sample optimization for cryo-EM analysis
RNA sample optimization for cryo-EM analysis
RNAs play critical roles in most biological processes. Although the three-dimensional (3D) structures of RNAs primarily de...
Author Correction: Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS
Author notesThese authors contributed equally: Wesley E. Robertson, Louise F. H. Funke, Daniel de la Torre, Julius Fredens...
Biolayer interferometry for measuring the kinetics of protein–protein interactions and nanobody binding
Biolayer interferometry for measuring the kinetics of protein–protein interactions and nanobody binding
Protein–protein interactions underpin nearly all biological processes, and understanding the molecular mechanisms th...
Seamless site-directed mutagenesis in complex cloned DNA sequences using the RedEx method
Seamless site-directed mutagenesis in complex cloned DNA sequences using the RedEx method
Seamless site-directed mutagenesis is an important technique for studying protein functions, tuning enzyme catalytic activ...
Using clusterProfiler to characterize multiomics data
Using clusterProfiler to characterize multiomics data
With the advent of multiomics, software capable of multidimensional enrichment analysis has become increasingly crucial fo...
A multi-glycomic platform for the analysis of food carbohydrates
A multi-glycomic platform for the analysis of food carbohydrates
Carbohydrates comprise the largest fraction of most diets and exert a profound impact on health. Components such as simple...
Preamplification-free viral RNA diagnostics with single-nucleotide resolution using MARVE, an origami paper-based colorimetric nucleic acid test
Preamplification-free viral RNA diagnostics with single-nucleotide resolution using MARVE, an origami paper-based colorimetric nucleic acid test
The evolution and mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgent concerns as they pos...
FIND-seq: high-throughput nucleic acid cytometry for rare single-cell transcriptomics
FIND-seq: high-throughput nucleic acid cytometry for rare single-cell transcriptomics
Rare cells have an important role in development and disease, and methods for isolating and studying cell subsets are ther...
Analysis of nanomaterial biocoronas in biological and environmental surroundings
Analysis of nanomaterial biocoronas in biological and environmental surroundings
A biomolecular coating, or biocorona, forms on the surface of engineered nanomaterials (ENMs) immediately as they enter bi...
Surface nanocoating of bacteria as a versatile platform to develop living therapeutics
Surface nanocoating of bacteria as a versatile platform to develop living therapeutics
Bacteria have been extensively utilized as living therapeutics for disease treatment due to their unique characteristics, ...
In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis
In vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis
Human early embryonic development is the cornerstone of a healthy baby. Abnormal early embryonic development may lead to d...
Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils
Stress-free single-cell transcriptomic profiling and functional genomics of murine eosinophils
Eosinophils are a class of granulocytes with pleiotropic functions in homeostasis and various human diseases. Nevertheless...
An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells
An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells
Pigs share anatomical and physiological traits with humans and can serve as a large-animal model for translational medicin...
Light-mediated intracellular polymerization
Light-mediated intracellular polymerization
The synthesis of synthetic intracellular polymers offers groundbreaking possibilities in cellular biology and medical rese...
Pan-evolutionary and regulatory genome architecture delineated by an integrated macro- and microsynteny approach
Pan-evolutionary and regulatory genome architecture delineated by an integrated macro- and microsynteny approach
The forthcoming massive genome data generated by the Earth BioGenome Project will open up a new era of comparative genomic...
BridGE: a pathway-based analysis tool for detecting genetic interactions from GWAS
BridGE: a pathway-based analysis tool for detecting genetic interactions from GWAS
Genetic interactions have the potential to modulate phenotypes, including human disease. In principle, genome-wide associa...
Generating human bone marrow organoids for disease modeling and drug discovery
Generating human bone marrow organoids for disease modeling and drug discovery
The bone marrow supports and regulates hematopoiesis, responding to physiological requirements for blood cell production o...
A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO2
A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO2
Isotopically carbon-labeled α-amino acids are valuable synthetic targets that are increasingly needed in pharmacology...
Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks
Standardized production of hPSC-derived cardiomyocyte aggregates in stirred spinner flasks
A promising cell-therapy approach for heart failure aims at differentiating human pluripotent stem cells (hPSCs) into func...
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice
Establishing reliable intravenous catheterization in mice with optical implants allows the combination of neural manipulat...
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation
The central nervous system (CNS) comprises diverse and morphologically complex cells. To understand the molecular basis of...
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Synthesis and functionalization of scalable and versatile 2D protein films via amyloid-like aggregation
Two-dimensional (2D) protein films can be used to modify the properties of surfaces, and find applications predominantly i...
Small RNA structural biochemistry in a post-sequencing era
Small RNA structural biochemistry in a post-sequencing era
High-throughput sequencing has had an enormous impact on small RNA research during the past decade. However, sequencing on...
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
Spatiotemporal control of RNA metabolism and CRISPR–Cas functions using engineered photoswitchable RNA-binding proteins
RNA molecules perform various crucial roles in diverse cellular processes, from translating genetic information to decodin...
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst
The tail-to-head terpene (THT) cyclization is a biochemical process that gives rise to many terpene natural product skelet...
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