Zhang, P. et al. Transcriptome profiling of human pre-implantation development. PLoS ONE 4, e7844 (2009).
Article PubMed PubMed Central Google Scholar
Hertig, A. T., Rock, J. & Adams, E. C. A description of 34 human ova within the first 17 days of development. Am. J. Anat. 98, 435–493 (1956).
Article CAS PubMed Google Scholar
Sathananthan, H., Selvaraj, K. & Clark, J. The fine structure of human germ layers in vivo: clues to the early differentiation of embryonic stem cells in vitro. Reprod. Biomed. Online 23, 227–233 (2011).
Müller, F. & O’Rahilly, R. The primitive streak, the caudal eminence and related structures in staged human embryos. Cells Tissues Organs 177, 2–20 (2004).
Rossant, J. & Tam, P. P. L. Early human embryonic development: blastocyst formation to gastrulation. Dev. Cell 57, 152–165 (2022).
Article CAS PubMed Google Scholar
Hill, M. A. Developing the digital Kyoto collection in education and research. Anat. Rec. 301, 998–1003 (2018).
Tyser, R. C. V. et al. Single-cell transcriptomic characterization of a gastrulating human embryo. Nature 600, 285–289 (2021).
Article CAS PubMed PubMed Central Google Scholar
Li, L. et al. Single-cell multi-omics sequencing of human early embryos. Nat. Cell Biol. 20, 847–858 (2018).
Article CAS PubMed Google Scholar
Guo, F. et al. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 161, 1437–1452 (2015).
Article CAS PubMed Google Scholar
Yan, L. et al. Single-cell RNA-seq profiling of human preimplantation embryos and embryonic stem cells. Nat. Struct. Mol. Biol. 20, 1131–1139 (2013).
Article CAS PubMed Google Scholar
Deglincerti, A. et al. Self-organization of the in vitro attached human embryo. Nature 533, 251–254 (2016).
Article CAS PubMed Google Scholar
Shahbazi, M. N. et al. Self-organization of the human embryo in the absence of maternal tissues. Nat. Cell Biol. 18, 700–708 (2016).
Article CAS PubMed PubMed Central Google Scholar
Zhou, F. et al. Reconstituting the transcriptome and DNA methylome landscapes of human implantation. Nature 572, 660–664 (2019).
Article CAS PubMed Google Scholar
Xiang, L. et al. A developmental landscape of 3D-cultured human pre-gastrulation embryos. Nature 577, 537–542 (2020).
Article CAS PubMed Google Scholar
Wang, Y. et al. A single-cell characterization of human post-implantation embryos cultured in vitro delineates morphogenesis in primary syncytialization. Front. Cell Dev. Biol. 10, 835445 (2022).
Article PubMed PubMed Central Google Scholar
Lv, B. et al. Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses. PLoS Biol. 17, e3000187 (2019).
Article CAS PubMed PubMed Central Google Scholar
West, R. C. et al. Dynamics of trophoblast differentiation in peri-implantation-stage human embryos. Proc. Natl Acad. Sci. USA 116, 22635–22644 (2019).
Article CAS PubMed PubMed Central Google Scholar
Xu, Y. et al. A single-cell transcriptome atlas profiles early organogenesis in human embryos. Nat. Cell Biol. 25, 604–615 (2023).
Zeng, B. et al. The single-cell and spatial transcriptional landscape of human gastrulation and early brain development. Cell Stem Cell 30, 851–866.e7 (2023).
Article CAS PubMed PubMed Central Google Scholar
de Graeff, N., De Proost, L. & Munsie, M. ‘Ceci n’est pas un embryon?’ The ethics of human embryo model research. Nat. Methods 20, 1863–1867 (2023).
Article PubMed PubMed Central Google Scholar
Nakamura, T., Fujiwara, K., Saitou, M. & Tsukiyama, T. Non-human primates as a model for human development. Stem Cell Rep. 16, 1093–1103 (2021).
Ma, H. et al. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science 366, eaax7890 (2019).
Article CAS PubMed Google Scholar
Niu, Y. et al. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 366, eaaw5754 (2019).
Article CAS PubMed Google Scholar
Zhai, J. et al. Neurulation of the cynomolgus monkey embryo achieved from 3D blastocyst culture. Cell 186, 2078–2091.e18 (2023).
Article CAS PubMed Google Scholar
Gong, Y. et al. Ex utero monkey embryogenesis from blastocyst to early organogenesis. Cell 186, 2092–2110.e23 (2023).
Article CAS PubMed Google Scholar
Hsu, Y. C. In vitro development of individually cultured whole mouse embryos from blastocyst to early somite stage. Dev. Biol. 68, 453–461 (1979).
Article CAS PubMed Google Scholar
Libbus, B. L. & Hsu, Y. C. Sequential development and tissue organization in whole mouse embryos cultured from blastocyst to early somite stage. Anat. Rec. 197, 317–329 (1980).
Article CAS PubMed Google Scholar
Chen, L. T. & Hsu, Y. C. Development of mouse embryos in vitro: preimplantation to the limb bud stage. Science 218, 66–68 (1982).
Article CAS PubMed Google Scholar
Hsu, Y. C. Differentiation in vitro of mouse embryos beyond the implantation stage. Nature 239, 200–202 (1972).
Article CAS PubMed Google Scholar
Bedzhov, I., Leung, C. Y., Bialecka, M. & Zernicka-Goetz, M. In vitro culture of mouse blastocysts beyond the implantation stages. Nat. Protoc. 9, 2732–2739 (2014).
Article CAS PubMed Google Scholar
Aguilera-Castrejon, A. et al. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis. Nature 593, 119–124 (2021).
Article CAS PubMed Google Scholar
Gu, Z. et al. A uterus-inspired niche drives blastocyst development to the early organogenesis. Adv. Sci. 9, e2202282 (2022).
Yan, R. et al. Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat. Genet. 55, 130–143 (2023).
Comments (0)