Belkaid, Y. & Harrison, O. J. Homeostatic immunity and the microbiota. Immunity 46, 562–576 (2017).
Article CAS PubMed PubMed Central Google Scholar
Ansaldo, E., Farley, T. K. & Belkaid, Y. Control of immunity by the microbiota. Annu. Rev. Immunol. 39, 449–479 (2021).
Article CAS PubMed Google Scholar
Huus, K. E. et al. Commensal bacteria modulate immunoglobulin A binding in response to host nutrition. Cell Host Microbe 27, 909–921.e5 (2020).
Article CAS PubMed Google Scholar
Mantis, N. J., Rol, N. & Corthesy, B. Secretory IgA’s complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 4, 603–611 (2011).
Article CAS PubMed PubMed Central Google Scholar
Nakajima, A. et al. IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria. J. Exp. Med. 215, 2019–2034 (2018).
Article CAS PubMed PubMed Central Google Scholar
Vujkovic-Cvijin, I. et al. The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces. Sci. Transl. Med. 14, eabl3927 (2022).
Article CAS PubMed PubMed Central Google Scholar
Castro-Dopico, T. et al. Anti-commensal IgG drives intestinal inflammation and type 17 immunity in ulcerative colitis. Immunity 50, 1099–1114.e10 (2019).
Article CAS PubMed PubMed Central Google Scholar
Hegazy, A. N. et al. Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation. Gastroenterology 153, 1320–1337.e16 (2017).
Article CAS PubMed Google Scholar
Martin, J. C. et al. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. Cell 178, 1493–1508.e20 (2019).
Article CAS PubMed PubMed Central Google Scholar
Uzzan, M. et al. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nat. Med. 28, 766–779 (2022).
Article CAS PubMed PubMed Central Google Scholar
Paun, A. et al. Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children. Sci. Immunol. 4, eaau8125 (2019).
Article CAS PubMed PubMed Central Google Scholar
Chriswell, M. E. et al. Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum. Sci. Transl. Med. 14, eabn5166 (2022).
Article CAS PubMed PubMed Central Google Scholar
Smith, G. P. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science 228, 1315–1317 (1985).
Article CAS PubMed Google Scholar
McCafferty, J., Griffiths, A. D., Winter, G. & Chiswell, D. J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552–554 (1990).
Article CAS PubMed Google Scholar
Connor, D. O., Zantow, J., Hust, M., Bier, F. F. & von Nickisch-Rosenegk, M. Identification of novel immunogenic proteins of Neisseria gonorrhoeae by phage display. PLoS ONE 11, e0148986 (2016).
Article PubMed PubMed Central Google Scholar
Kugler, J., Zantow, J., Meyer, T. & Hust, M. Oligopeptide m13 phage display in pathogen research. Viruses 5, 2531–2545 (2013).
Article PubMed PubMed Central Google Scholar
Meyer, T. et al. Identification of immunogenic proteins and generation of antibodies against Salmonella Typhimurium using phage display. BMC Biotechnol. 12, 29 (2012).
Article CAS PubMed PubMed Central Google Scholar
Verma, S. et al. Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers. Immunity 57, 1428–1441.e8 (2024).
Article CAS PubMed PubMed Central Google Scholar
Boonyaratanakornkit, J. & Taylor, J. J. Techniques to study antigen-specific B cell responses. Front. Immunol. 10, 1694 (2019).
Article CAS PubMed PubMed Central Google Scholar
Prior, J. T. et al. Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization. npj Vaccines 8, 80 (2023).
Article CAS PubMed PubMed Central Google Scholar
Taylor, J. J. et al. Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen. J. Exp. Med. 209, 2065–2077 (2012).
Article CAS PubMed PubMed Central Google Scholar
Ansaldo, E. et al. Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis. Science 364, 1179–1184 (2019).
Article CAS PubMed PubMed Central Google Scholar
Kau, A. L. et al. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl. Med. 7, 276ra224 (2015).
Nowosad, C. R. et al. Tunable dynamics of B cell selection in gut germinal centres. Nature 588, 321–326 (2020).
Article CAS PubMed PubMed Central Google Scholar
Palm, N. W. et al. Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158, 1000–1010 (2014).
Article CAS PubMed PubMed Central Google Scholar
Olm, M. R., Spencer, S. P., Takeuchi, T., Silva, E. L. & Sonnenburg, J. L. Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut. Nat. Microbiol. 10, 112–125 (2025).
Article CAS PubMed Google Scholar
Shapiro, J. M. et al. Immunoglobulin A targets a unique subset of the microbiota in inflammatory bowel disease. Cell Host Microbe 29, 83–93.e3 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chen, H. et al. BCR selection and affinity maturation in Peyer’s patch germinal centres. Nature 582, 421–425 (2020).
Article CAS PubMed PubMed Central Google Scholar
Lindner, C. et al. Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine. J. Exp. Med. 209, 365–377 (2012).
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