Xia, Y. Nanomaterials at work in biomedical research. Nat. Mater. 7, 758–760 (2008).

Article  CAS  PubMed  Google Scholar 

Gao, X. et al. Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst. Nat. Commun. 15, 7915 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, R., Jiang, B., Fan, K., Gao, L. & Yan, X. Designing nanozymes for in vivo applications. Nat. Rev. Bioeng. 2, 849–868 (2024).

Article  CAS  Google Scholar 

Wu, J. et al. Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation. Nat. Commun. 15, 6174 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye, T. et al. Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia–reperfusion injury. Nat. Commun. 15, 1682 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhen, W., Weichselbaum, R. R. & Lin, W. Nanoparticle-mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy. Adv. Mater. 35, 2206370 (2023).

Article  CAS  Google Scholar 

Zhou, Q. et al. Tumor abnormality-oriented nanomedicine design. Chem. Rev. 123, 10920–10989 (2023).

Article  CAS  PubMed  Google Scholar 

Guo, Y., Hu, P. & Shi, J. Nanomedicine remodels tumor microenvironment for solid tumor immunotherapy. J. Am. Chem. Soc. 146, 10217–10233 (2024).

Article  CAS  PubMed  Google Scholar 

Wei, H. & Wang, E. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem. Soc. Rev. 42, 6060–6093 (2013).

Article  CAS  PubMed  Google Scholar 

Wu, J. et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II). Chem. Soc. Rev. 48, 1004–1076 (2019).

Article  CAS  PubMed  Google Scholar 

Wu, C. et al. A nonferrous ferroptosis-like strategy for antioxidant inhibition-synergized nanocatalytic tumor therapeutics. Sci. Adv. 7, eabj8833 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, B., Chen, Y. & Shi, J. Nanocatalytic medicine. Adv. Mater. 31, 1901778 (2019).

Article  Google Scholar 

Hou, M., Wang, L., Chen, Y. & Shi, J. Tumor-selective catalytic nanomedicine by nanocatalyst delivery. Nat. Commun. 8, 357 (2017).

Article  Google Scholar 

Zhen, W. et al. Specific “unlocking” of a nanozyme-based butterfly effect to break the evolutionary fitness of chaotic tumors. Angew. Chem. Int. Ed. 59, 9491–9497 (2020).

Article  CAS  Google Scholar 

Zhang, Y. et al. Chirality-dependent reprogramming of macrophages by chiral nanozymes. Angew. Chem. Int. Ed. 62, e202307076 (2023).

Article  CAS  Google Scholar 

Yu, B., Wang, W., Sun, W., Jiang, C. & Lu, L. Defect engineering enables synergistic action of enzyme-mimicking active centers for high-efficiency tumor therapy. J. Am. Chem. Soc. 143, 8855–8865 (2021).

Article  CAS  PubMed  Google Scholar 

Li, M. et al. Structural design of single-atom catalysts for enhancing petrochemical catalytic reaction process. Adv. Mater. 36, 2313661 (2024).

Article  CAS  Google Scholar 

Lei, Z. et al. Single metal atoms catalysts—promising candidates for next generation energy storage and conversion devices. EcoMat 4, e12186 (2022).

Article  CAS  Google Scholar 

Chang, B., Zhang, L., Wu, S., Sun, Z. & Cheng, Z. Engineering single-atom catalysts toward biomedical applications. Chem. Soc. Rev. 51, 3688–3734 (2022).

Article  CAS  PubMed  Google Scholar 

Xia, Y., Sayed, M., Zhang, L., Cheng, B. & Yu, J. Single-atom heterogeneous photocatalysts. Chem Catal. 1, 1173–1214 (2021).

Article  CAS  Google Scholar 

Xiong, P. et al. Cytotoxicity of metal-based nanoparticles: from mechanisms and methods of evaluation to pathological manifestations. Adv. Sci. 9, 2106049 (2022).

Article  CAS  Google Scholar 

Yang, F., Deng, D., Pan, X., Fu, Q. & Bao, X. Understanding nano effects in catalysis. Natl. Sci. Rev. 2, 183–201 (2015).

Article  CAS  Google Scholar 

Zhang, T. Single-atom catalysis: far beyond the matter of metal dispersion. Nano Lett. 21, 9835–9837 (2021).

Article  CAS  PubMed  Google Scholar 

Wang, D. & Zhao, Y. Single-atom engineering of metal–organic frameworks toward healthcare. Chem 7, 2635–2671 (2021).

Article  CAS  Google Scholar 

Fei, H. et al. Single atom electrocatalysts supported on graphene or graphene-like carbons. Chem. Soc. Rev. 48, 5207–5241 (2019).

Article  CAS  PubMed  Google Scholar 

Liu, L. & Corma, A. Metal catalysts for heterogeneous catalysis: from single atoms to nanoclusters and nanoparticles. Chem. Rev. 118, 4981–5079 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun, T. et al. SACs on non-carbon substrates: can they outperform for water splitting? Adv. Funct. Mater. 33, 2301526 (2023).

Article  CAS  Google Scholar 

Song, W. et al. Review of carbon support coordination environments for single metal atom electrocatalysts (SACS). Adv. Mater. 36, 2301477 (2024).

Article  CAS  Google Scholar 

Liu, J. C., Tang, Y., Wang, Y. G., Zhang, T. & Li, J. Theoretical understanding of the stability of single-atom catalysts. Natl. Sci. Rev. 5, 638–641 (2018).

Article  CAS  Google Scholar 

Li, J. et al. Challenges and perspectives of single-atom-based catalysts for electrochemical reactions. JACS Au 3, 736–755 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, A., Li, J. & Zhang, T. Hererogeneous single-atom catalysis. Nat. Rev. Chem. 2, 65–81 (2018).

Article  CAS  Google Scholar 

Liu, Y. et al. Multi-enzyme co-expressed dual-atom nanozymes induce cascade immunogenic ferroptosis via activating interferon-γ and targeting arachidonic acid metabolism. J. Am. Chem. Soc. 145, 8965–8978 (2023).

Article  CAS  PubMed  Google Scholar 

Liu, Y. et al. Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity. J. Am. Chem. Soc. 146, 3675–3688 (2024).

Article  CAS  PubMed  Google Scholar 

Shen, J. et al. Atomic engineering of single-atom nanozymes for biomedical applications. Adv. Mater. 36, 2313406 (2024).

Article  CAS  Google Scholar 

Jiao, L. et al. When nanozymes meet single-atom catalysis. Angew. Chem. Int. Ed. 59, 2565–2576 (2020).

Article  CAS  Google