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Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5
Microglia regulate myelin clearance and cholesterol metabolism after demyelination via interferon regulatory factor 5
Interferon regulatory factor 5 (IRF5) is a transcription factor that plays a role in orchestrating innate immune responses...
METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation
METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation
Pancreatic cancer is highly lethal and has a poor prognosis. Research has highlighted the role of circular RNAs and m6A me...
Correction: Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling
Correction: Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research
Genome-wide profiling and functional characterization of circular RNAs in neural development and injury: insights from a rat model research
Circular RNAs (circRNAs) have re-emerged as promising gene regulators in various physiological and pathological conditions...
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10
Previous studies have indicated that PRDM16 suppresses apoptosis and ferroptosis, thereby mitigating the development of AK...
Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection
Porcine epidemic diarrhea virus (PEDV) has caused significant losses in the pork industry, but the mechanism of PEDV infec...
Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia
Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia
Propionic acidemia is an inborn error of metabolism caused by mutations in either the PCCA or PCCB genes. Patients with pr...
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells
Hepatocytes are crucial for drug screening, disease modeling, and clinical transplantation, yet generating functional hepa...
Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis
Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis
Increased adipogenic differentiation and decreased osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs...
Micro-proteomics reveals distinct protein profiles and SPARC/FGF2/CDH1 regulation of human Sertoli cells between Sertoli cell-only syndrome and normal men
Micro-proteomics reveals distinct protein profiles and SPARC/FGF2/CDH1 regulation of human Sertoli cells between Sertoli cell-only syndrome and normal men
Sertoli cell-only syndrome (SCOS) is one of the most severe non-obstructive azoospermia (NOA) types, since only Sertoli ce...
Heat shock protein 60 manipulates Foot-and-Mouth disease virus replication by regulating mitophagy
Heat shock protein 60 manipulates Foot-and-Mouth disease virus replication by regulating mitophagy
Mitochondria serve as the hubs of cellular signaling, energetics, and redox balance under physiological conditions. Mitoch...
Syndecan-3 positively regulates the pro-inflammatory function of macrophages
Syndecan-3 positively regulates the pro-inflammatory function of macrophages
The tumour microenvironment (TME) is a highly structured ecosystem that surrounds a tumour and plays a crucial role in tum...
An update on mammalian and non-mammalian animal models for biomarker development in neurodegenerative disorders
An update on mammalian and non-mammalian animal models for biomarker development in neurodegenerative disorders
Neurodegeneration is one of the leading factor for death globally, affecting millions of people. Developing animal models ...
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression
Loss of NgBR causes neuronal damage through decreasing KAT7-mediated RFX1 acetylation and FGF1 expression
Parkinson’s disease (PD) is a common neurodegenerative movement disorder characterized by dopaminergic neuron loss i...
Mosquito immune responses to parasites that limit malaria transmission
Mosquito immune responses to parasites that limit malaria transmission
The mosquito immune system is a major barrier that malaria parasites must overcome for their successful development and di...
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation
Sarcopenia, the age-related decline in muscle mass and function, poses a major health risk to the elderly population. Alth...
Immunogenicity and protective efficacy of an inactivated bivalent vaccine containing two recombinant H1N1 and H3N2 swine influenza virus strains
Immunogenicity and protective efficacy of an inactivated bivalent vaccine containing two recombinant H1N1 and H3N2 swine influenza virus strains
The wild-type H1N1 and H3N2 swine influenza virus (SIV) strains are unsuitable for vaccine production because of high leth...
S146 and M148 within the mature chain domain of PSMB4 are crucial for degrading PRRSV nsp1α
S146 and M148 within the mature chain domain of PSMB4 are crucial for degrading PRRSV nsp1α
Porcine reproductive and respiratory syndrome virus (PRRSV) is a single-stranded positive-sense RNA virus with an envelope...
Adenine base editing of CFTR using receptor targeted nanoparticles restores function to G542X cystic fibrosis airway epithelial cells
Adenine base editing of CFTR using receptor targeted nanoparticles restores function to G542X cystic fibrosis airway epithelial cells
The cystic fibrosis (CF) causing variant G542X harbours a premature translation stop signal in the cystic fibrosis transme...
Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Apache is a neuronal player in autophagy required for retrograde axonal transport of autophagosomes
Neurons are dependent on efficient quality control mechanisms to maintain cellular homeostasis and function due to their p...
MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat
MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat
The leading cause of steroid-induced femoral head osteonecrosis (ONFH) is the imbalance of bone homeostasis. Bone marrow-d...
AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine
AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine
Intraepithelial lymphocytes (IELs) reside in the epithelial layer and protect against foreign pathogens, maintaining the e...
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Stabilization of RRBP1 mRNA via an m6A-dependent manner in prostate cancer constitutes a therapeutic vulnerability amenable to small-peptide inhibition of METTL3
Mounting evidence has implicated the RNA m6A methylation catalyzed by METTL3 in a wide range of physiological and patholog...
Mechanisms for assembly of the nucleoplasmic reticulum
Mechanisms for assembly of the nucleoplasmic reticulum
The nuclear envelope consists of an outer membrane connected to the endoplasmic reticulum, an inner membrane facing the nu...
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Mutations in fibronectin dysregulate chondrogenesis in skeletal dysplasia
Fibronectin (FN) is an extracellular matrix glycoprotein essential for the development and function of major vertebrate or...
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
NPRL2 promotes TRIM16-mediated ubiquitination degradation of Galectin-3 to prevent CD8+T lymphocyte cuproptosis in glioma
Our previous study found that tumor suppressor nitrogen permease regulator like-2(NPRL2) is frequently downregulated in gl...
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
The role of immune cells settled in the bone marrow on adult hematopoietic stem cells
Certain immune cells, including neutrophils, macrophages, dendritic cells, B cells, Breg cells, CD4+ T cells, CD8+ T cells...
KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability
KLF15 suppresses stemness of pancreatic cancer by decreasing USP21-mediated Nanog stability
The existence of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) is considered to be the key factor fo...
SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus
SENP1 mediates zinc-induced ZnT6 deSUMOylation at Lys-409 involved in the regulation of zinc metabolism in Golgi apparatus
Zinc (Zn) transporters contribute to the maintenance of intracellular Zn homeostasis in vertebrate, whose activity and fun...
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
CFTR is an anion channel that has evolved from the mold of an ABC transporter. It possesses specific structural features, ...
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