Kvisgaard LK, Hjulsager CK, Kristensen CS, Lauritsen KT, Larsen LE (2013) Genetic and antigenic characterization of complete genomes of type 1 Porcine reproductive and respiratory viruses (PRRSV) isolated in Denmark over a period of 10 years. Virus Res 178(2):197–205

CAS  PubMed  Google Scholar 

Liu JK, Wei CH, Dai AL, Fan KW, Yang BH, Huang CF, Li XH, Yang XY, Luo ML (2017) Complete genomic characterization of two European-genotype Porcine reproductive and respiratory syndrome virus isolates in Fujian Province of China. Arch Virol 162(3):823–833

CAS  PubMed  Google Scholar 

Wu ZY, Chang T, Wang DC, Zhang HL, Liu HZ, Huang XY, Tian ZJ, Tian XX, Liu D, An TQ, Yan Y (2024) Genomic surveillance and evolutionary dynamics of type 2 Porcine reproductive and respiratory syndrome virus in China spanning the African swine fever outbreak. Virus Evol 10(1):veae016

PubMed  PubMed Central  Google Scholar 

Laplana M, Estany J, Fraile LJ, Pena RN (2020) Resilience effects of SGK1 and TAP1 DNA markers during PRRSV outbreaks in reproductive sows. Anim (Basel) 10(5):902

Google Scholar 

Wang Y, Li R, Qiao SL, Wang JX, Liu HL, Li ZJ, Ma HF, Yang L, Ruan HY, Weng MY, Hiscox JA, Stewart JP, Nan YC, Zhang GP, Zhou EM (2020) Structural characterization of non-structural protein 9 complexed with specific nanobody pinpoints two important residues involved in Porcine reproductive and respiratory syndrome virus replication. Front Microbiol 11:581856

PubMed  PubMed Central  Google Scholar 

Thiel HJ, Meyers G, Stark R, Tautz N, Rumenapf T, Unger G, Conzelmann KK (1993) Molecular characterization of positive-strand RNA viruses: pestiviruses and the Porcine reproductive and respiratory syndrome virus (PRRSV). Arch Virol Suppl 7:41–52

CAS  PubMed  Google Scholar 

Cui XY, Xia DS, Huang XY, Sun Y, Shi M, Zhang JQ, Li GW, Yang YB, Wang HW, Cai XH, An TQ (2022) Analysis of Recombinant characteristics based on 949 PRRSV-2 genomic sequences obtained from 1991 to 2021 shows that viral multiplication ability contributes to dominant recombination. Microbiol Spectr 10(5):e0293422

PubMed  Google Scholar 

Liu BJ, Luo LZ, Shi ZQ, Ju HB, Yu LX, Li GX, Cui J (2023) Research progress of Porcine reproductive and respiratory syndrome virus NSP2 protein. Viruses 15(12):2310

CAS  PubMed  PubMed Central  Google Scholar 

Yoo DW, Song C, Sun Y, Du YJ, Kim O, Liu HC (2010) Modulation of host cell responses and evasion strategies for Porcine reproductive and respiratory syndrome virus. Virus Res 154(1–2):48–60

CAS  PubMed  Google Scholar 

Li RQ, Chen C, He J, Zhang LL, Zhang L, Guo YY, Zhang WT, Tan K, Huang JH (2019) E3 ligase ASB8 promotes Porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral nsp1alpha protein and degrading host IKK beta kinase. Virology 532:55–68

CAS  PubMed  Google Scholar 

Li W, Zhang MT, Wang YS, Zhao SJ, Xu PL, Cui ZY, Chen J, Xia PG, Zhang YN (2024) PRRSV GP5 inhibits the antivirus effects of chaperone-mediated autophagy by targeting LAMP2A. mBio 15(8):e0053224

PubMed  Google Scholar 

Sun YN, Xue F, Guo Y, Ma M, Hao N, Zhang XC, Lou ZY, Li XM, Rao ZH (2009) Crystal structure of Porcine reproductive and respiratory syndrome virus leader protease nsp1α. J Virol 83(21):10931–10940

CAS  PubMed  PubMed Central  Google Scholar 

Xue F, Sun YN, Yan LM, Zhao C, Chen J, Bartlam M, Li XM, Lou ZY, Rao ZH (2010) The crystal structure of Porcine reproductive and respiratory syndrome virus nonstructural protein nsp1β reveals a novel metal-dependent nuclease. J Virol 84(13):6461–6471

CAS  PubMed  PubMed Central  Google Scholar 

Tijms MA, Nedialkova DD, Zevenhoven-Dobbe JC, Gorbalenya AE, Snijder EJ (2007) Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease. J Virol 81(19):10496–10505

CAS  PubMed  PubMed Central  Google Scholar 

Song C, Krell P, Yoo DW (2010) Nonstructural protein 1alpha subunit-based Inhibition of NF-kappaB activation and suppression of interferon-beta production by Porcine reproductive and respiratory syndrome virus. Virology 407(2):268–280

CAS  PubMed  Google Scholar 

Han MY, Du YJ, Song C, Yoo DW (2013) Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the Porcine reproductive and respiratory syndrome virus nsp1alpha subunit. Virus Res 172(1–2):54–65

CAS  PubMed  Google Scholar 

Beura LK, Sarkar SN, Kwon B, Subramaniam S, Jones C, Pattnaik AK, Osorio FA (2010) Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation. J Virol 84(3):1574–1584

CAS  PubMed  Google Scholar 

Zheng YH, Jiang DD, Sui C, Wu XJ, Hu Y, Lee CH, Cong XY, Li JT, Lu Y, Wang Z, Du YJ, Qi J, Huang J (2024) PRRSV nsp1alpha degrades TRIM25 through proteasome system to inhibit host antiviral immune response. Vet Microbiol 296:110173

CAS  PubMed  Google Scholar 

Jing HY, Fang LR, Ding Z, Wang D, Hao WQ, Gao L, Ke WT, Chen HC, Xiao SB (2017) Porcine reproductive and respiratory syndrome virus nsp1alpha inhibits NF-kappaB activation by targeting the linear ubiquitin chain assembly complex. J Virol 91(3):e01911–e01916

CAS  PubMed  PubMed Central  Google Scholar 

Wang XD, Shao CY, Wang LY, Li QJ, Song HH, Fang WH (2016) The viral non-structural protein 1 alpha (Nsp1alpha) inhibits p53 apoptosis activity by increasing murine double minute 2 (mdm2) expression in Porcine reproductive and respiratory syndrome virus (PRRSV) early-infected cells. Vet Microbiol 184:73–79

CAS  PubMed  Google Scholar 

Murata S, Yashiroda H, Tanaka K (2009) Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol 10(2):104–115

CAS  PubMed  Google Scholar 

Tyedmers J, Mogk A, Bukau B (2010) Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol 11(11):777–788

CAS  PubMed  Google Scholar 

Montenegro-Venegas C, Fienko S, Anni D, Pina-Fernandez E, Frischknecht R, Fejtova A (2020) Bassoon inhibits proteasome activity via interaction with PSMB4. Cell Mol Life Sci 78(4):1545–1563

PubMed  PubMed Central  Google Scholar 

Yang CH, Hsu CF, Lai XQ, Chan YR, Li HC, Lo SY (2022) Cellular PSMB4 protein suppresses influenza A virus replication through targeting ns1 protein. Viruses 14(10):2277

CAS  PubMed  PubMed Central  Google Scholar 

Yi HY, Wang QM, Lu LC, Ye RR, Xie EM, Yu ZQ, Sun YK, Chen Y, Cai MK, Qiu YW, Wu QW, Peng J, Wang H, Zhang GH (2023) PSMB4 degrades the Porcine reproductive and respiratory syndrome virus nsp1alpha protein via the autolysosome pathway and induces the production of type I interferon. J Virol 97(4):e0026423

PubMed  Google Scholar 

Yokoyama T, Brien KJO, Franklin TM, Zuo BLG, Zuo MXG, Merideth MA, Introne WJ, Gochuico BR (2024) Impairment of renal function in hermansky-pudlak syndrome. Am J Nephrol 9:1–10

Google Scholar 

Shi XQ, An XJ, Yang L, Wu ZP, Zan DN, Li ZH, Pang BS, Chen Y, Li JJ, Tan PP, Ma RZ, Fang QH, Ma YM, Jin JW (2021) Reticulocalbin 3 deficiency in alveolar epithelium attenuated LPS-induced ALI via NF-kappaB signaling. Am J Physiol Lung Cell Mol Physiol 320(4):L627–L639

CAS  PubMed  Google Scholar 

He Y, Alejo S, Johnson JD, Jayamohan S, Sareddy GR (2023) Reticulocalbin 3 is a novel mediator of glioblastoma progression. Cancers (Basel) 15(7):2008

CAS  PubMed  Google Scholar 

Li L, Bai J, Fan H, Yan JF, Li SH, Jiang P (2020) E2 ubiquitin-conjugating enzyme UBE2L6 promotes senecavirus A proliferation by stabilizing the viral RNA polymerase. PLoS Pathog 16(10):e1008970

CAS  PubMed  PubMed Central  Google Scholar 

Orfali N, Shan-Krauer D, O’Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL (2020) Inhibition of UBE2L6 attenuates isgylation and impedes ATRA‐induced differentiation of leukemic cells. Mol Oncol 14(6):1297–1309

CAS  PubMed  PubMed Central  Google Scholar 

Hou YY, Zhang CY, Liu L, Yu Y, Shi L, Qin Y (2024) WDR61 ablation triggers R-loop accumulation and suppresses breast cancer progression. FEBS J 291(15):3417–3431

CAS  PubMed  Google Scholar 

Barman P, Ferdoush J, Kaja A, Chakraborty P, Uprety B, Bhaumik R, Bhaumik R, Bhaumik SR (2024) Ubiquitin-proteasome system regulation of a key gene regulatory factor, Paf1C. Gene 894:148004

CAS  PubMed  Google Scholar 

Wang JJ, Li HY, Xue BB, Deng RL, Huang X, Xu Y, Chen SW, Tian RY, Wang XT, Xun Z, Sang M, Zhu HZ (2020) IRF1 promotes the innate immune response to viral infection by enhancing the activation of IRF3. J Virol 94(22):e01231–e01220

CAS  PubMed  PubMed Central  Google Scholar 

Ngberg KS, Schwartz S (1999) Poly(C)-binding protein interacts with the hepatitis C virus 5’ untranslated region. J Gen Virol 80(Pt 6):1371–1376

Google Scholar 

Monaco V, Iacobucci I, Cane L, Cipollone I, Ferrucci V, Antonellis Pde, Quaranta M, Pascarella S, Zollo M, Monti M (2024) SARS-CoV-2 uses Spike glycoprotein to control the host’s anaerobic metabolism by inhibiting LDHB. Int J Biol Macromol 278(Pt 3):134638

CAS  PubMed