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A SAMBA for chemically induced proximity
A SAMBA for chemically induced proximity
SAMBA, a new chemically induced proximity system, overcomes the cost, complexity and reversibility challenges of such syst...
Functional targeting of membrane transporters and enzymes to peroxisomes
Functional targeting of membrane transporters and enzymes to peroxisomes
Engineered peroxisomes hold promise as a highly versatile platform for compartmentalizing engineered metabolic pathways, i...
Click biology highlights the opportunities from reliable biological reactions
Click biology highlights the opportunities from reliable biological reactions
Click chemistry is a powerful concept that refers to a set of covalent bond-forming reactions with highly favorable proper...
Noncoded cancer antigens
Aberrant translation in cancer cells can lead to the expression of peptides from genetic sequences outside of annotated op...
Phase in phase
TDP-43 is a nuclear protein that can bind RNA and have an important role in regulating various RNA-related biological proc...
Deep learning-designed dynamics
Deep learning-based approaches have advanced the de novo design of static proteins and enabled robust prediction of struct...
A transposon-like strategy for proteins
A transposon-like strategy for proteins
Transposition is normally considered a DNA-based process. Now, scientists have devised a means to carry out a similar tran...
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Developing macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource...
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Engineering a xylose fermenting yeast for lignocellulosic ethanol production
Lignocellulosic ethanol is produced by yeast fermentation of lignocellulosic hydrolysates generated by chemical pretreatme...
Author Correction: Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Yu ImaiPresent address: Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University, Naga...
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway
These authors contributed equally: Jie Shi, Shangying Wang.Department of Bioengineering, University of California, Berkele...
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT
The post-translational modification of intracellular proteins through O-linked β-N-acetylglucosamine (O-GlcNAc) is a ...
Open-ended molecular recording of sequential cellular events into DNA
Open-ended molecular recording of sequential cellular events into DNA
Genetically encoded DNA recorders noninvasively convert transient biological events into durable mutations in a cell’...
A key to sperm–egg union
The fusion of egg and sperm requires an egg surface protein, JUNO in mammals or Bouncer in fish, and several conserved spe...
Assembly-activated aggregation
The aberrant aggregation of the presynaptic protein α-synuclein (α-syn) is a hallmark of synucleinopathies, which include ...
Guiding the pioneer
Forkhead box protein A1 (FOXA1) is a pioneer transcription factor that binds to chromatin at a canonical DNA motif. This b...
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer
The phosphoinositide 3-kinase (PI3K)–Akt axis is one of the most frequently activated pathways and is demonstrated a...
Unlocking saponin biosynthesis in soapwort
Unlocking saponin biosynthesis in soapwort
Soapwort (Saponaria officinalis) is a flowering plant from the Caryophyllaceae family with a long history of human use as ...
Genetically engineered synthetic cells activate cargo release upon temperature shift
Genetically engineered synthetic cells activate cargo release upon temperature shift
We combine RNA thermometer genetic switches, cell-free protein expression and synthetic cell design to create cell-sized s...
Splice-modifying drug mechanisms
Splice-modifying drug mechanisms
A new study combines massively parallel assays, transcriptomics and biophysical modeling to provide a framework for analyz...
Direct RAS inhibitors turn 10
Direct RAS inhibitors turn 10
RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a persona...
Metabolic determinants of germinal center B cell formation and responses
Metabolic determinants of germinal center B cell formation and responses
Germinal center (GC) B cells are crucial for the generation of GCs and long-lived humoral immunity. Here we report that on...
Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity
Phospholipid biosynthesis modulates nucleotide metabolism and reductive capacity
Phospholipid and nucleotide syntheses are fundamental metabolic processes in eukaryotic organisms, with their dysregulatio...
Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus
Restoring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus
Infections by Staphylococcus aureus have been treated historically with β-lactam antibiotics. However, these antibiot...
Stress it up
AKT is a serine/threonine kinase that is essential for cellular metabolism and proliferation and is overactive in cancer c...
Reeling in microorganisms
The metabolic engineering of microorganisms is an attractive platform for bioremediation and the industrial production of ...
Switching off the stress response
Cells respond to adverse environmental changes by activating stress response pathways. However, the continuous activation ...
Profiling the proximal proteome of the activated μ-opioid receptor
Profiling the proximal proteome of the activated μ-opioid receptor
The μ-opioid receptor (μOR) represents an important target of therapeutic and abused drugs. So far, most underst...
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation
Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contribute...
The death gaze of MEDUSA
The death gaze of MEDUSA
Chemogenetic profiling can reveal genetic determinants that coordinate phenotypic responses to therapeutics, along with pr...
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