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Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
The resting zone (RZ) in mammalian growth plates is critical for maintaining and regulating chondrocyte turnover during lo...
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains large...
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but ...
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM...
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
Osteoarthritis (OA) is one of the most common degenerative joint diseases in the elderly, increasing in prevalence and pos...
Characterizing a new rat model of chronic pain after spine surgery
Characterizing a new rat model of chronic pain after spine surgery
Chronic pain after spine surgery (CPSS) is a complex disorder characterized by multifactorial pathogenesis that occurs in ...
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Aging is a pivotal risk factor for intervertebral disc degeneration (IVDD) and chronic low back pain (LBP). The restoratio...
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resis...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Three decades of protein-fragment complementation
This year marks the 30th anniversary of the publication of a novel approach to measuring protein–protein in...
How proteins sense their cellular environment
The cellular environment is critical to protein function. How is information from many cellular components decoded in orde...
Telomere function and regulation from mouse models to human ageing and disease
Telomere function and regulation from mouse models to human ageing and disease
Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When ...
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed to the dysfunction of nucleu...
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Pharmacologic or genetic targeting of peripheral nerves prevents peri-articular traumatic heterotopic ossification
Heterotopic ossification (HO) is a pathological process that commonly arises following severe polytrauma, characterized by...
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma
Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall surviv...
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
Musculoskeletal traumatic injuries (MTI) involve soft tissue lesions adjacent to a bone fracture leading to fibrous nonuni...
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
Stem Cell Therapy as a Potential Treatment of Non-Alcoholic Steatohepatitis-Related End-Stage Liver Disease: A Narrative Review
To review recent research using various stem cell-related therapies, including bone marrow, adipose tissue, hematopoietic ...
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
Maternal Gene Delivery for the Prevention and Treatment of Obstetric Conditions
There is an urgent unmet clinical need for effective therapies for obstetric complications such as fetal growth restrictio...
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of t...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
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