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Collective migration modes in development, tissue repair and cancer
Collective migration modes in development, tissue repair and cancer
Migrating cells have key functions in shaping tissues during development, repairing tissues after development and supporti...
How machine learning can help us understand what we have grown in the dish
How machine learning can help us understand what we have grown in the dish
A machine learning model was trained to quantify how closely neurons differentiated in a dish from stem cells resemble tho...
Decoding the interactions and functions of non-coding RNA with artificial intelligence
Decoding the interactions and functions of non-coding RNA with artificial intelligence
In addition to encoding proteins, mRNAs have context-specific regulatory roles that contribute to many cellular processes....
Key challenges and recommendations for defining organelle membrane contact sites
Key challenges and recommendations for defining organelle membrane contact sites
Intracellular membrane contact sites (MCSs) between organelles have crucial roles in cellular signalling and homeostasis. ...
Good neighbours transfer nucleotides
Good neighbours transfer nucleotides
Adequate levels of nucleotides are essential to ensure genetic stability of proliferating cells. A study finds gap-junctio...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Nearly half of the genome of humans and other mammals consists of transposable elements (TEs). Recent advancements in sequ...
Regulation of inflammatory processes by caspases
Regulation of inflammatory processes by caspases
Historically, mammalian caspases (a group of cysteine proteases) have been catalogued into two main families based on majo...
Molecular machineries and pathways of mitochondrial protein transport
Molecular machineries and pathways of mitochondrial protein transport
Mitochondria contain about 1,000–1,500 different proteins, most of which are encoded by the nuclear genome and synth...
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone
The resting zone (RZ) in mammalian growth plates is critical for maintaining and regulating chondrocyte turnover during lo...
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
The crosstalk between megakaryocytic lineage cells and the skeletal system has just begun to be explored but remains large...
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is required for mesenchymal progenitor proliferation and fracture repair
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but ...
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Osteoporosis represents a prevalent and debilitating comorbidity in patients diagnosed with type 2 diabetes mellitus (T2DM...
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
LATS1-modulated ZBTB20 perturbing cartilage matrix homeostasis contributes to early-stage osteoarthritis
Osteoarthritis (OA) is one of the most common degenerative joint diseases in the elderly, increasing in prevalence and pos...
Characterizing a new rat model of chronic pain after spine surgery
Characterizing a new rat model of chronic pain after spine surgery
Chronic pain after spine surgery (CPSS) is a complex disorder characterized by multifactorial pathogenesis that occurs in ...
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain
Aging is a pivotal risk factor for intervertebral disc degeneration (IVDD) and chronic low back pain (LBP). The restoratio...
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch
Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resis...
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Iron-oxide-nanoparticle-tagged Mesenchymal Stem Cell Exosomes in Therapeutics
Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small frac...
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
Mesenchymal Stromal Cell Immunomodulatory Potential for Orthopedic Applications can be fine-tuned via 3D nano-engineered Scaffolds
This concise review delves into the pivotal role of three-dimensional (3D) nanostructured scaffolds in fostering mesenchym...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Three decades of protein-fragment complementation
This year marks the 30th anniversary of the publication of a novel approach to measuring protein–protein in...
How proteins sense their cellular environment
The cellular environment is critical to protein function. How is information from many cellular components decoded in orde...
Telomere function and regulation from mouse models to human ageing and disease
Telomere function and regulation from mouse models to human ageing and disease
Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When ...
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclasts control endochondral ossification via regulating acetyl-CoA availability
Osteoclast is critical in skeletal development and fracture healing, yet the impact and underlying mechanisms of their met...
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development
Osteoarthritis (OA) is the most common form of arthritic disease, and phenotypic modification of chondrocytes is an import...
Bone targeted nano-drug and nano-delivery
Bone targeted nano-drug and nano-delivery
There are currently no targeted delivery systems to satisfactorily treat bone-related disorders. Many clinical drugs consi...
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Osteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone forma...
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