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Collective migration modes in development, tissue repair and cancer
Collective migration modes in development, tissue repair and cancer
Migrating cells have key functions in shaping tissues during development, repairing tissues after development and supporti...
How machine learning can help us understand what we have grown in the dish
How machine learning can help us understand what we have grown in the dish
A machine learning model was trained to quantify how closely neurons differentiated in a dish from stem cells resemble tho...
Decoding the interactions and functions of non-coding RNA with artificial intelligence
Decoding the interactions and functions of non-coding RNA with artificial intelligence
In addition to encoding proteins, mRNAs have context-specific regulatory roles that contribute to many cellular processes....
Key challenges and recommendations for defining organelle membrane contact sites
Key challenges and recommendations for defining organelle membrane contact sites
Intracellular membrane contact sites (MCSs) between organelles have crucial roles in cellular signalling and homeostasis. ...
Good neighbours transfer nucleotides
Good neighbours transfer nucleotides
Adequate levels of nucleotides are essential to ensure genetic stability of proliferating cells. A study finds gap-junctio...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Nearly half of the genome of humans and other mammals consists of transposable elements (TEs). Recent advancements in sequ...
Regulation of inflammatory processes by caspases
Regulation of inflammatory processes by caspases
Historically, mammalian caspases (a group of cysteine proteases) have been catalogued into two main families based on majo...
Molecular machineries and pathways of mitochondrial protein transport
Molecular machineries and pathways of mitochondrial protein transport
Mitochondria contain about 1,000–1,500 different proteins, most of which are encoded by the nuclear genome and synth...
Grand roles for microproteins
Grand roles for microproteins
Valerie Tornini discusses two studies that identified functional roles for small proteins encoded by short open reading fr...
RNA communication between organisms inspires innovative eco-friendly strategies for disease control
Evidence shows that RNA trafficking is a key communication mechanism across kingdoms and species, but how RNAs are secrete...
Connecting cells through TNT
Connecting cells through TNT
Tunnelling nanotubes, which are actin-based protrusions different from filopodia and cytokinetic bridges, connect cells in...
Paleoproteomics sheds light on million-year-old fossils
It is now well established that ancient proteins endure, and remain informative, much longer than DNA. Accordingly, sequen...
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment
In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific rec...
Three decades of protein-fragment complementation
This year marks the 30th anniversary of the publication of a novel approach to measuring protein–protein in...
How proteins sense their cellular environment
The cellular environment is critical to protein function. How is information from many cellular components decoded in orde...
Telomere function and regulation from mouse models to human ageing and disease
Telomere function and regulation from mouse models to human ageing and disease
Telomeres protect the ends of chromosomes but shorten following cell division in the absence of telomerase activity. When ...
Heterochromatin as a balancing act between transcription and gene silencing
Heterochromatin as a balancing act between transcription and gene silencing
An elegant study revealed the distinct roles of different H3K9 methylation states in heterochromatin formation and function.
Long-lived proteomes in healthy ovaries
Long-lived proteomes in healthy ovaries
Many proteins in the mouse ovary are extremely stable; they enhance proteostasis and limit protein aggregation, thereby su...
Virus–host warfare by PROTACs
Virus–host warfare by PROTACs
The studies that paved the way for the development of PROTACs (proteolysis-targeting chimeras) as therapeutic strategies, ...
The discovery of cyclin-dependent kinases
The discovery of cyclin-dependent kinases
Paul Nurse discusses how a 1971 paper by Culotti and Hartwell inspired him to investigate the cell cycle in fission yeast,...
Cellular and pathological functions of tau
Cellular and pathological functions of tau
Tau protein is involved in various cellular processes, including having a canonical role in binding and stabilization of m...
Regulation of and challenges in targeting NAD+ metabolism
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a reduction–oxidation (redox)...
What does it take to build a nucleus?
What does it take to build a nucleus?
Abigail Buchwalter recounts what happened to the nuclei of cells lacking all lamin genes.
MYB-related proteins make chloroplasts
MYB-related proteins make chloroplasts
MYB-related transcription factors are found to function in chloroplast biogenesis alongside GLK in the distantly related s...
Localized translation in the embryo
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the im...
A code within the genetic code
A code within the genetic code
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and m...
Protein N-terminal acetylation is entering the degradation end game
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation re...
Single-cell live volume measurements using the fluorescence exclusion method
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion met...
Cellular and molecular mechanisms of skin wound healing
Cellular and molecular mechanisms of skin wound healing
Wound healing is a complex process that involves the coordinated actions of many different tissues and cell lineages. It r...
How ancient RNA survives and what we can learn from it
Although normally transient, RNA can persist postmortem when preserved by cold, desiccation or chemical treatment. In this...
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