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Interrogation of Structure–Activity Relationships in Charge Variants of Therapeutic IgG2s Enabled by Free-Flow Isoelectric Focusing Fractionation
Interrogation of Structure–Activity Relationships in Charge Variants of Therapeutic IgG2s Enabled by Free-Flow Isoelectric Focusing Fractionation
Recombinant immunoglobulin G2 (IgG2) antibodies are effective neutralization agents or antagonists with high medical value...
Progress and Challenges in the Treatment of Fabry Disease
Progress and Challenges in the Treatment of Fabry Disease
Fabry disease is a rare but life-threatening, X-linked, inherited lysosomal storage disorder in which globotriaosylceramid...
Demand- Versus Supply-Side Policies in Market Penetration of Biosimilars: Which is More Effective?
Demand- Versus Supply-Side Policies in Market Penetration of Biosimilars: Which is More Effective?
To evaluate the impact of demand- and supply-side policies on the biosimilar market penetration and identify effective str...
Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy
Emerging Therapy in Osteoarthritis: Mesenchymal Stem Cells, Secretomes, and Using Hydrogels to Enhance Efficacy
Osteoarthritis is a prevalent condition among middle-aged and elderly populations characterized primarily by the progressi...
Beyond Cost: Observations on Clinical and Patient Benefits of Biosimilars in Real-World Settings
Beyond Cost: Observations on Clinical and Patient Benefits of Biosimilars in Real-World Settings
The introduction of biosimilars into healthcare systems globally is recognized by many as a healthcare success. Despite th...
The Use of Biologics for Thyroid Eye Disease
The Use of Biologics for Thyroid Eye Disease
Thyroid eye disease (TED) is the most common extrathyroidal manifestation of Graves’ disease. It is an autoimmune di...
Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders
Emerging Role of Targeted Monoclonal Antibodies in Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune disease that results in recurring, often severe attac...
Lipid-Lowering RNA Therapeutics for Atherosclerotic Cardiovascular Disease Prevention: A State−of−the−Art Review
Lipid-Lowering RNA Therapeutics for Atherosclerotic Cardiovascular Disease Prevention: A State−of−the−Art Review
Despite the modern era of effective and safe high-intensity statins and non-statin agents, a significant portion of patien...
Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study
Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study
Comparative immunogenicity is a key regulatory requirement for biosimilars. In a streamlined biosimilar development proces...
Bispecific Antibodies in Hematologic Malignancies: Attacking the Frontline
Bispecific Antibodies in Hematologic Malignancies: Attacking the Frontline
Since blinatumomab’s approval as the first bispecific antibody (BsAb) in cancer therapy, these immunomodulatory agen...
Individual Prescribing Incentives for Biosimilars in Selected European Countries and the USA: a Scoping Literature Review
Individual Prescribing Incentives for Biosimilars in Selected European Countries and the USA: a Scoping Literature Review
The uptake of biosimilar medicines in Europe and the USA remains highly variable and at times slow, despite the significan...
Introduction of Biopharmaceuticals in Europe: A Cross-Sectional Study of Early Diffusion Patterns and Data Availability
Introduction of Biopharmaceuticals in Europe: A Cross-Sectional Study of Early Diffusion Patterns and Data Availability
Biopharmaceuticals add value in the treatment of many diseases but different health systems in Europe face clinical and ec...
Targeting CD20 for B-cell Depletion in Autoimmune Kidney Disease: Next Generation
Targeting CD20 for B-cell Depletion in Autoimmune Kidney Disease: Next Generation
Anti-CD20 monoclonal antibodies are gaining clinical relevance in the nephrology community due to their demonstrated effic...
The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
The use of in vivo and ex vivo diagnostic tools for delayed hypersensitivity reactions (DHRs) associated with iodinated co...
Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions
Discordant Restoration of TCR Expression and Function by CD247 Somatic Reversions
The CD247 chain of the T-cell receptor (TCR) is essential for normal T cell development and function. Reported CD247-defic...
Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses
Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses
Natural Killer (NK) cells naturally recognize and eliminate leukemic cells. However, the molecular interactions that gover...
Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights
Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights
Germline pathogenic variants in the mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) encodes a casp...