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Macrophage involvement in idiopathic inflammatory myopathy: pathogenic mechanisms and therapeutic prospects
Macrophage involvement in idiopathic inflammatory myopathy: pathogenic mechanisms and therapeutic prospects
Idiopathic inflammatory myopathies are a group of systemic autoimmune diseases characterized by chronic muscle inflammatio...
Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling
Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling
Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and ...
Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis
Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis
Pathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also h...
Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins
Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins
HMG-CoA reductase inhibitors are well-known medications in the treatment of cardiovascular disorders due to their pleiotro...
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
Intestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protect...
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
MAP3K8 is a potential therapeutic target in airway epithelial inflammation
We have previously discovered clusters of sequentially negative and positive modulators of acute inflammation during cytok...
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Impairment of Nrf2 signaling in the hippocampus of P301S tauopathy mice model aligns with the cognitive impairment and the associated neuroinflammation
Mice transgenic for human P301S tau protein exhibit many characteristics of the human tauopathies, including the formation...
Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms tha...
Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke exposure exaggerates bleomycin-induced collagen overexpression during pulmonary fibrogenesis
Environmental tobacco smoke (ETS) is known to cause lung inflammatory and injurious responses. Smoke exposure is associate...
EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
Beyond their crucial role in hemostasis, platelets possess the ability to regulate inflammation and combat infections thro...
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo
Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the maj...
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway
Interplay between systemic inflammation and programmed cell death contributes to the pathogenesis of acute lung injury (AL...
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD
Exposure to noxious particles, including cigarette smoke and fine particulate matter (PM2.5), is a risk factor for chronic...
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Retraction Note: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: implications in vascular diseases
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. The...
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
SARS-CoV-2 infection as a model to study the effect of cinnamaldehyde as adjuvant therapy for viral pneumonia
The recent pandemic outbursts, due to SARS-CoV-2, have highlighted once more the central role of the inflammatory process ...
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Lipid from electronic cigarette-aerosol both with and without nicotine induced pro-inflammatory macrophage polarization and disrupted phagocytosis
Clinical cases and experimental evidence revealed that electronic cigarettes (ECIG) induce serious adverse health effects,...
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway
Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway infl...
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
Diabetes mellitus is one of the causes of poor ventricular remodelling and poor cardiac recovery after myocardial infarcti...
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Sodium butyrate alleviates R97-116 peptide-induced myasthenia gravis in mice by improving the gut microbiota and modulating immune response
Fermented butyrate exhibits an anti-inflammatory response to maintain immune homeostasis within the gut. However, the effe...
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation
Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inf...
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonar...
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates
Cardiometabolic diseases are associated with low-grade inflammation early in life and persists into old age. The long late...
Advances in the study of macrophage polarization in inflammatory immune skin diseases
Advances in the study of macrophage polarization in inflammatory immune skin diseases
When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-in...
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
Genome-wide identification and functional analysis of dysregulated alternative splicing profiles in sepsis
An increasing body of evidence now shows that the long-term mortality of patients with sepsis are associated with various ...
Inhibition of COX-2 signaling favors E. coli during urinary tract infection
Inhibition of COX-2 signaling favors E. coli during urinary tract infection
To avoid the overuse of antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), acting via cyclooxygenase (COX) inhib...
Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
Effect of perioperative acupoint electrical stimulation on macrophages in mice under operative stress
The strong perioperative stress response caused by surgical anesthesia can significantly suppress immune function, and the...
Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Sodium pyruvate exerts protective effects against cigarette smoke extract-induced ferroptosis in alveolar and bronchial epithelial cells through the GPX4/Nrf2 axis
Ferroptosis in alveolar and bronchial epithelial cells is one of the main mechanisms underlying the development of chronic...
Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Correction: Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite...
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