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The world’s largest experiment in human immunology
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Siglecs as modulators of macrophage phenotype and function
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The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system
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High-throughput N-glycan analysis in aging and inflammaging: State of the art and future directions
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Systems analysis of innate and adaptive immunity in Long COVID
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Systems biology of B cells in COVID-19
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Introduction to the special issue: B cells in cancer immunosurveillance
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B cell clonality in cancer
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The origins, manifestations, and potential treatments of allergic disorders
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Introduction to the Special Issue: Pyroptosis in Immunity and Inflammation
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Durability of immune responses to SARS-CoV-2 infection and vaccination
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Early life microbiome influences on development of the mucosal innate immune system
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To die or not to die: Gasdermins in intestinal health and disease
To die or not to die: Gasdermins in intestinal health and disease
The first member of the gasdermin family was identified in the upper gastrointestinal tract in 2000 [1]. Up until now, the...
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
AhRAryl hydrocarbon receptorASHalcoholic steatohepatitisACLFacute-on-chronic-liver-failureASBTApical Sodium-dependent BA T...
Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond
Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond
Type I interferons (IFNs) constitute a major antiviral defense system of the body. They were discovered over 60 years ago ...
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Toolkit for mapping the clonal landscape of tumor-infiltrating B cells
Resolving intratumoral B cells and IG-producing plasma cell content is critical for our understanding of tumor-immunity in...
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy
Volume 71, February 2024, 101848Author links open overlay panel, AbstractDendritic cells (DCs) are professional antigen-pr...
Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis
Regulated cell death in neutrophils: From apoptosis to NETosis and pyroptosis
Volume 70, November 2023, 101849Author links open overlay panel, , , AbstractNeutrophils are among the most abundant immun...
Regulatory T cells in allergic inflammation
Regulatory T cells in allergic inflammation
APCsAntigen-presenting cellsAT2Type II alveolar cellsαVβ8alpha-V:beta-8 integrinα4β7Alpha 4 beta 7 integrinCCR6C-C Motif C...
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Chemical modulation of gasdermin D activity: Therapeutic implications and consequences
Volume 70, November 2023, 101845Author links open overlay panel, Highlights•The gasdermin family of proteins are terminal ...
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
The epithelial barrier: The gateway to allergic, autoimmune, and metabolic diseases and chronic neuropsychiatric conditions
KeywordsAllergyAutoimmune diseasesBarrier dysfunctionEpithelitisEpithelial barrier theoryLungsMetabolic diseasesMicrobiota...
The noncanonical inflammasome-induced pyroptosis and septic shock
The noncanonical inflammasome-induced pyroptosis and septic shock
AbbreviationAAK1AP2 Associated Kinase 1AOAHAcyloxyacyl hydrolaseCARDCaspase recruitment and activation domaincGASCyclic GM...
The immunology and cell biology of T cell aging
The immunology and cell biology of T cell aging
Volume 70, November 2023, 101843Author links open overlay panelJörg J. Goronzy, Nan-ping WengShow morePrevious article in ...
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Beyond youth: Understanding CAR T cell fitness in the context of immunological aging
Volume 70, November 2023, 101840Author links open overlay panel, , , AbstractPopulation aging, a pervasive global demograp...
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS
Vaccines are among the greatest inventions in medicine, leading to the elimination or control of numerous diseases, includ...
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Better safe than sorry: Naive T-cell dynamics in healthy ageing
Volume 70, November 2023, 101839Author links open overlay panel, , AbstractIt is well-known that the functioning of the im...
Epigenetic and transcriptional control of gasdermins
Epigenetic and transcriptional control of gasdermins
Cells undergo an inflammatory programmed lytic cell death called ‘pyroptosis’ (with the Greek roots ‘fiery’), often featur...
Proteostasis in T cell aging
Proteostasis in T cell aging
Volume 70, November 2023, 101838Author links open overlay panel, , , AbstractAging leads to a decline in immune cell funct...
Thymus aging and immune reconstitution, progresses and challenges
Thymus aging and immune reconstitution, progresses and challenges
Thymus is a primary lymphoid organ essential for the development of T lymphocytes. Age-related thymic involution is a prom...
The paradox of aging: Aging-related shifts in T cell function and metabolism
The paradox of aging: Aging-related shifts in T cell function and metabolism
Volume 70, November 2023, 101834Author links open overlay panel, , AbstractT cell survival, differentiation after stimulat...
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