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mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses
mRNA-1273 vaccinated inflammatory bowel disease patients receiving TNF inhibitors develop broad and robust SARS-CoV-2-specific CD8+ T cell responses
Author links open overlay panelJet van den Dijssel a b c, Mariël C. Duurland c d, Veronique AL. Konijn c d, Laura YL. Kumm...
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
P2RX7 gene variants associate with altered inflammasome assembly and reduced pyroptosis in chronic nonbacterial osteomyelitis (CNO)
Chronic nonbacterial osteomyelitis (CNO), an autoinflammatory bone disease primarily affecting children, can cause pain, h...
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by a...
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
miR-146a and miR-146b regulate the expression of ICAM-1 in giant cell arteritis
Giant cell arteritis (GCA) is a chronic inflammatory disease that affects large and medium-sized arteries. It is the most ...
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
Autoimmune diseases and female-specific cancer risk: A systematic review and meta-analysis
Volume 144, April 2024, 103187Author links open overlay panel, , Highlights•Patients with rheumatoid arthritis show a redu...
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
BackgroundThe significance of muscle biopsy as a diagnostic tool in idiopathic inflammatory myopathies (IIM) remains elusi...
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
Psoriasis represents a chronic inflammatory skin disorder and etiologically results from immune system dysregulation. Acro...
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
Modulation of PKM2 inhibits follicular helper T cell differentiation and ameliorates inflammation in lupus-prone mice
The growth, survival, and performance of immune effector functions of immune cells are closely linked to metabolism, and i...
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation
Ectopic CD4+ T cells in choroid plexus mediate neuropsychiatric lupus symptoms in mice via interferon-γ induced microglia activation
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the involvement of multiple organs [1]...
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production, inflammation,...
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
Targeting macrophages with phosphatidylserine-rich liposomes as a potential antigen-specific immunotherapy for type 1 diabetes
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting ...
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
Anti-DNA antibody-targeted D-peptide nanoparticles ameliorate lupus nephritis in MRL/lpr mice
Volume 145, May 2024, 103205Author links open overlay panel, , , , , , , , , , Highlights•Poor stability and non-kidney ta...
Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
Quantitative and structural changes of blood platelet cytoskeleton proteins in multiple sclerosis (MS)
KeywordsMultiple sclerosisBlood plateletsMegakaryocytesCytoskeleton proteinsβ1-tubulinβ-actinPlatelet overactivationPost-t...
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients
Crohn's disease (CD) is a chronic inflammatory disorder that affects all layers of the bowel wall, characterized by transm...
Interleukin-15 is a hair follicle immune privilege guardian
Interleukin-15 is a hair follicle immune privilege guardian
Alopecia areata (AA) is the most common chronic-relapsing inflammatory hair disease [1]. It represents one of the most com...
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement
Extracellular microRNAs induce dendritic cell-dependent joint inflammation and potentiate osteoclast differentiation via TLR7/8 engagement
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by destructive changes in bone and cartilage of m...
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases
Identifying the genetic association between systemic lupus erythematosus and the risk of autoimmune liver diseases
Autoimmune liver diseases (AILDs) are uncommon, chronic hepatic disorders characterized by abnormal immune attack on hepat...
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
Global and regional epidemiology of psoriatic arthritis in patients with psoriasis: A comprehensive systematic analysis and modelling study
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy characterized by enthesitis and synovitis associated with ...
Balancing efficacy and safety of complement inhibitors
Balancing efficacy and safety of complement inhibitors
Complement inhibitors have been approved for several immune-mediated diseases and they are considered the next paradigm-sh...
Peripheral helper T cells in human diseases
Peripheral helper T cells in human diseases
KeywordsPeripheral helper T cellsInterleukin-21B cellsAutoimmune diseasesInfectious diseasesMalignanciesAbbreviationsAnti-...
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown
Autoimmune diseases affect around 10 % of the world population, and are characterized by a complex etiology, combining gen...
Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease for which specific etiologic agents remain largely u...
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain
High-resolution HLA genotyping in inclusion body myositis refines 8.1 ancestral haplotype association to DRB1*03:01:01 and highlights pathogenic role of arginine-74 of DRβ1 chain
ObjectivesInclusion body myositis (IBM) is a progressive inflammatory-degenerative muscle disease of older individuals, wi...
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/Tc17 inflammation in giant cell arteritis
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) thro...
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions
Volume 142, January 2024, 103149Author links open overlay panel, , , , , , , , , , , Highlights•Autoimmune arthritis is re...
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints and produces pain, swelling, ...
Lung transplantation in pulmonary sarcoidosis
Lung transplantation in pulmonary sarcoidosis
Sarcoidosis is a multisystem inflammatory disease characterized by noncaseating granulomas of unknown etiology [1,2]. Up t...
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis
B lineage cells are critically involved in ANCA-associated vasculitis (AAV), evidenced by alterations in circulating B cel...
Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum
Novel biomarker discovery through comprehensive proteomic analysis of lupus mouse serum
Systemic lupus erythematosus (SLE; lupus) primarily affects women of reproductive age [1]. Unpredictable flares of inflamm...
Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus
Pemphigus is an organ-specific autoimmune bullous disease characterized by the presence of IgG autoantibodies (autoAbs) ta...
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