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Hereditary Combined Deficiency of the Vitamin K-Dependent Coagulation Factors
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Targeting c-MYC has a key role in hepatocellular carcinoma therapy
HCC is the most widespread variant of primary liver cancer and ranks among the leading causes of cancer-related mortality ...
Regulatory mechanisms and therapeutic targeting of metastatic tumor dormancy in colorectal cancer: A comprehensive review
According to the 2018 Global Cancer Statistics (Bray et al., 2018), colorectal cancer (CRC) constitutes approximately 10 %...
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review
Maria Gavriatopoulou, M.D. M.Sc. Ph.D. Medical Oncologist and Assistant Professor at the Department of Clinical Therapeuti...
Resistance mechanisms in anaplastic lymphoma kinase-positive lung cancer
Cancer is fundamentally a disease of dysregulated metabolism in which malignant cells reprogram standard biochemical pathw...
Dual roles of GM-CSF in breast cancer: Immunomodulation and therapeutic implications
Immunotherapy for cancer aims to eliminate or control tumors by activating or enhancing the patient's own immune system, p...
Unlock the code of MHC II-enabled Cancer immunotherapy
Despite advancements in cancer immunotherapy, challenges such as tumor immune escape, immunosuppressive tumor microenviron...
Targeting O-GlcNAcylation in tumor-associated inflammation: From molecular mechanisms to cancer therapy
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible protein post-translational modification (PTM) that pr...
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics
Vanessa M. Beutgen, Ph.D. Staff Scientist at the Core Facility and Institute of Translational Proteomics, Philipps-Univers...
Targeting the DNA damage response to enhance radiotherapy in soft tissue sarcomas
Judith V.M.G. Bovée, M.D. Ph.D. is a clinician scientist and Professor of Pathology at Leiden University Medical Center, w...