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Targeting c-MYC has a key role in hepatocellular carcinoma therapy
HCC is the most widespread variant of primary liver cancer and ranks among the leading causes of cancer-related mortality ...
Regulatory mechanisms and therapeutic targeting of metastatic tumor dormancy in colorectal cancer: A comprehensive review
According to the 2018 Global Cancer Statistics (Bray et al., 2018), colorectal cancer (CRC) constitutes approximately 10 %...
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review
Maria Gavriatopoulou, M.D. M.Sc. Ph.D. Medical Oncologist and Assistant Professor at the Department of Clinical Therapeuti...
Role of machine learning in molecular pathology for breast cancer: A review on gene expression profiling and RNA sequencing application
Kousar Ahmadi, MSc in Anatomical Sciences, Research Assistant at the Neuroscience Research Centre, Shahid Beheshti Univers...
Comparison of third-generation tyrosine kinase inhibitor (TKI) ponatinib with first- and second-generation TKIs for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia: A systematic review and bias-corrected meta-analysis
The t(9;22) (q34;q11) translocation, commonly known as the Philadelphia chromosome (Ph), results in the formation of the B...
Resistance mechanisms in anaplastic lymphoma kinase-positive lung cancer
Cancer is fundamentally a disease of dysregulated metabolism in which malignant cells reprogram standard biochemical pathw...
Dual roles of GM-CSF in breast cancer: Immunomodulation and therapeutic implications
Immunotherapy for cancer aims to eliminate or control tumors by activating or enhancing the patient's own immune system, p...
Unlock the code of MHC II-enabled Cancer immunotherapy
Despite advancements in cancer immunotherapy, challenges such as tumor immune escape, immunosuppressive tumor microenviron...
Targeting O-GlcNAcylation in tumor-associated inflammation: From molecular mechanisms to cancer therapy
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible protein post-translational modification (PTM) that pr...
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics
Vanessa M. Beutgen, Ph.D. Staff Scientist at the Core Facility and Institute of Translational Proteomics, Philipps-Univers...
Targeting the DNA damage response to enhance radiotherapy in soft tissue sarcomas
Judith V.M.G. Bovée, M.D. Ph.D. is a clinician scientist and Professor of Pathology at Leiden University Medical Center, w...
IGF-1R inhibitors in cancer: A review of available evidence and future outlook
Insulin-like growth factor (IGF) and its receptors IGF-1R and IGF-2R have roles in the promotion and progression of cancer...
A new era for radium-223? Optimizing treatment by balancing efficacy and toxicity through combination therapies
Giovanni Farinea, MD — Medical Oncologist, University of Turin, Italy. Expert in precision medicine and translational onco...
The role of PIK3CA mutation in lobular breast cancer in the era of precision oncology – A systematic review
Invasive lobular breast cancer (ILC) is the second most common subtype of breast carcinoma, comprising approximately 15 % ...
Trimodal treatment vs radical cystectomy for muscle-invasive bladder cancer: The neglected impact of informative censoring. A systematic review and meta-analysis
Approximately 25 % of bladder cancer is muscle-invasive at the time of diagnosis (muscle-invasive bladder cancer [MIBC]) (...
Predictive performance of the clinicopathologic gene expression profile (CP-GEP) in identifying cutaneous melanoma patients for whom sentinel lymph node biopsy is unnecessary: A systematic review and meta-analysis
Sydney Ch’ng, MD, Ph.D. Surgeon and academic with experience in plastic, reconstructive and head and neck surgery. Clinica...
The effects of race on anti-PD-(L)1 monoclonal antibodies in non-small cell lung cancer: A systematic literature review and meta-analysis
Nicola Normanno, MD. Director of the Cell Biology and Biotherapy Unit of INT Fondazione “G. Pascale” from 2005 to April 20...
Anticancer mechanisms and applications based on γδ T cells in cancer immunotherapy
Cancer continues to be a leading cause of global mortality, accounting for approximately 10 million fatalities annually (Z...
Dual-target CAR-T cell therapy: A new strategy to improve the therapeutic effect of hematological malignancies
Chimeric antigen receptor T cell (CAR-T) therapy represents a significant milestone in tumor immunotherapy, demonstrating ...
Endocrine consequences of cranial irradiation in children: Mechanisms, impacts, and sex differences
Yiran Xu, MD, Ph.D. Pediatric researcher with expertise in the pathogenesis and intervention strategies for perinatal brai...
Disparities in Clinical Trial Enrollment– Focus on CAR-T and Bispecific Antibody Therapies
Disparities in Clinical Trial Enrollment– Focus on CAR-T and Bispecific Antibody Therapies
Recent studies show that unresolved disparities hinder enrollment to clinical trials, equitable distribution of treatments...
Monoclonal Gammopathy-Associated Neuropathy
Monoclonal Gammopathy-Associated Neuropathy
Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with ...
Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies
Navigating the Economic Burden of Multiple Myeloma: Insights into Cost-effectiveness of CAR-T and Bispecific Antibody Therapies
Multiple myeloma is a chronic malignancy and with evolving treatment options, understanding the economic burden and cost-e...
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications
More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MP...
Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes
Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by high molecular and genomic heterogeneity. According...
Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses
Unravelling neutropenic enterocolitis: insights from gut microbiota, and intestinal barrier analyses
Neutropenic enterocolitis (NE) is a severe digestive complication of chemotherapy, primarily affecting patients with acute...
Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines
Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines
Recent advancements in immunotherapy, particularly Chimeric antigen receptor (CAR)-T cell therapy and cancer vaccines, hav...
Developments in nanotechnology approaches for the treatment of solid tumors
Developments in nanotechnology approaches for the treatment of solid tumors
Nanotechnology has revolutionized cancer therapy by introducing advanced drug delivery systems that enhance therapeutic ef...
Immunotherapy in breast cancer: current landscape and emerging trends
Immunotherapy in breast cancer: current landscape and emerging trends
Breast cancer remains one of the most prevalent malignancies worldwide, underscoring an urgent need for innovative therape...
Proteome analysis of platelets in Essential Thrombocythemia couples metabolism to platelet reactivity
Proteome analysis of platelets in Essential Thrombocythemia couples metabolism to platelet reactivity
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