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Targeting c-MYC has a key role in hepatocellular carcinoma therapy
HCC is the most widespread variant of primary liver cancer and ranks among the leading causes of cancer-related mortality ...
Regulatory mechanisms and therapeutic targeting of metastatic tumor dormancy in colorectal cancer: A comprehensive review
According to the 2018 Global Cancer Statistics (Bray et al., 2018), colorectal cancer (CRC) constitutes approximately 10 %...
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review
Maria Gavriatopoulou, M.D. M.Sc. Ph.D. Medical Oncologist and Assistant Professor at the Department of Clinical Therapeuti...
Role of machine learning in molecular pathology for breast cancer: A review on gene expression profiling and RNA sequencing application
Kousar Ahmadi, MSc in Anatomical Sciences, Research Assistant at the Neuroscience Research Centre, Shahid Beheshti Univers...
Comparison of third-generation tyrosine kinase inhibitor (TKI) ponatinib with first- and second-generation TKIs for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia: A systematic review and bias-corrected meta-analysis
The t(9;22) (q34;q11) translocation, commonly known as the Philadelphia chromosome (Ph), results in the formation of the B...
Resistance mechanisms in anaplastic lymphoma kinase-positive lung cancer
Cancer is fundamentally a disease of dysregulated metabolism in which malignant cells reprogram standard biochemical pathw...
Dual roles of GM-CSF in breast cancer: Immunomodulation and therapeutic implications
Immunotherapy for cancer aims to eliminate or control tumors by activating or enhancing the patient's own immune system, p...
Unlock the code of MHC II-enabled Cancer immunotherapy
Despite advancements in cancer immunotherapy, challenges such as tumor immune escape, immunosuppressive tumor microenviron...
Targeting O-GlcNAcylation in tumor-associated inflammation: From molecular mechanisms to cancer therapy
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible protein post-translational modification (PTM) that pr...
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics
Vanessa M. Beutgen, Ph.D. Staff Scientist at the Core Facility and Institute of Translational Proteomics, Philipps-Univers...
Targeting the DNA damage response to enhance radiotherapy in soft tissue sarcomas
Judith V.M.G. Bovée, M.D. Ph.D. is a clinician scientist and Professor of Pathology at Leiden University Medical Center, w...
IGF-1R inhibitors in cancer: A review of available evidence and future outlook
Insulin-like growth factor (IGF) and its receptors IGF-1R and IGF-2R have roles in the promotion and progression of cancer...
A new era for radium-223? Optimizing treatment by balancing efficacy and toxicity through combination therapies
Giovanni Farinea, MD — Medical Oncologist, University of Turin, Italy. Expert in precision medicine and translational onco...
The role of PIK3CA mutation in lobular breast cancer in the era of precision oncology – A systematic review
Invasive lobular breast cancer (ILC) is the second most common subtype of breast carcinoma, comprising approximately 15 % ...
Trimodal treatment vs radical cystectomy for muscle-invasive bladder cancer: The neglected impact of informative censoring. A systematic review and meta-analysis
Approximately 25 % of bladder cancer is muscle-invasive at the time of diagnosis (muscle-invasive bladder cancer [MIBC]) (...
Predictive performance of the clinicopathologic gene expression profile (CP-GEP) in identifying cutaneous melanoma patients for whom sentinel lymph node biopsy is unnecessary: A systematic review and meta-analysis
Sydney Ch’ng, MD, Ph.D. Surgeon and academic with experience in plastic, reconstructive and head and neck surgery. Clinica...
The effects of race on anti-PD-(L)1 monoclonal antibodies in non-small cell lung cancer: A systematic literature review and meta-analysis
Nicola Normanno, MD. Director of the Cell Biology and Biotherapy Unit of INT Fondazione “G. Pascale” from 2005 to April 20...
Anticancer mechanisms and applications based on γδ T cells in cancer immunotherapy
Cancer continues to be a leading cause of global mortality, accounting for approximately 10 million fatalities annually (Z...
Dual-target CAR-T cell therapy: A new strategy to improve the therapeutic effect of hematological malignancies
Chimeric antigen receptor T cell (CAR-T) therapy represents a significant milestone in tumor immunotherapy, demonstrating ...
Endocrine consequences of cranial irradiation in children: Mechanisms, impacts, and sex differences
Yiran Xu, MD, Ph.D. Pediatric researcher with expertise in the pathogenesis and intervention strategies for perinatal brai...
Targeting clonal mutations with synthetic microbes
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Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions
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A Comprehensive Review and Meta-Analysis of CTC Isolation Methods in Breast Cancer
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Prostate-specific membrane antigen as target for vasculature-directed therapeutic strategies in solid tumors
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A systematic literature review on clonal evolution events preceding relapse in multiple myeloma
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BCMA CAR-T induces complete and durable remission in plasmablastic lymphoma synchronous transformation of chronic lymphocytic leukemia: Case report and literature review
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Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment
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Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy
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The role of amino acid PET in radiotherapy target volume delineation for adult-type diffuse gliomas: A review of the literature
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Adapted physical activity programs for the prevention and treatment of musculoskeletal pain induced by aromatase inhibitors in non-metastatic breast cancer patient: A scoping review
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