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18F-FDG brain/cerebellum-to-liver ratios as prognostic factors
We read with great interest the article by Dingli et al. [1] in which they study the ratio of brain to liver 18F-FDG uptak...
Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study
Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study
Lymphoid neoplasms (LNs) are heterogeneous malignancies arising from lymphoid cells, displaying diverse clinical and molec...
Pediatric MDS in GATA2 deficiency, narrowing the scope
Kotmayer L, Kozyra EJ, Kang G, Strahm B, Yoshimi A, Sahoo SS, et al. Age-dependent phenotypic and molecular evolution of p...
Impact of residual clonal plasma cells in S-phase at the time of autologous stem cell transplantation on clinical outcomes
Impact of residual clonal plasma cells in S-phase at the time of autologous stem cell transplantation on clinical outcomes
Autologous stem cell transplantation (ASCT) is a key therapeutic strategy for many patients diagnosed with multiple myelom...
Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry
Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry
Despite the considerable effort to characterize the genomic landscape of chronic lymphocytic leukemia (CLL), published dat...
The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development
The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development
Patients with relapsed/refractory multiple myeloma (RRMM) have a poor prognosis and a need remains for novel effective the...
Defining ‘Intention’ in intention-to-treat survival outcomes for chimeric antigen receptor T-cell therapy
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma
Association of ADAM family members with proliferation signaling and disease progression in multiple myeloma
Multiple myeloma (MM) is a hematological malignancy whose curability is greatly challenged by recurrent patient relapses a...
Bispecific antibodies in the treatment of multiple myeloma
Bispecific antibodies in the treatment of multiple myeloma
The treatment paradigm in myeloma is constantly changing. Upfront use of monoclonal antibodies like daratumumab along with...
Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma
Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma
First-line treatment for advanced-stage diffuse large B-cell lymphoma (DLBCL) typically involves 6x R-CHOP21 or 6x R-CHOP2...
Synergistic effect of FMS-like tyrosine kinase-3 (FLT3) inhibitors combined with a CDK7 inhibitor in FLT3-ITD-mutated acute myeloid leukemia
Synergistic effect of FMS-like tyrosine kinase-3 (FLT3) inhibitors combined with a CDK7 inhibitor in FLT3-ITD-mutated acute myeloid leukemia
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, et al. Prognostic implication of FLT3 and N-RAS gene mutations ...
Multiomic analysis identifies a high-risk subgroup that predicts poor prognosis in t(8;21) acute myeloid leukemia
Multiomic analysis identifies a high-risk subgroup that predicts poor prognosis in t(8;21) acute myeloid leukemia
Begna KH, Xu X, Gangat N, Alkhateeb H, Patnaik MM, Al-Kali A, et al. Core-binding factor acute myeloid leukemia: long-term...
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy
Therapy-related acute myeloid leukemia (t-AML) often exhibits adverse (genetic) features. There is ongoing discussion on t...
A comprehensive approach to evaluate genetic abnormalities in multiple myeloma using optical genome mapping
A comprehensive approach to evaluate genetic abnormalities in multiple myeloma using optical genome mapping
Multiple myeloma (MM) is a plasma cell neoplasm (PCN) [1]. Sensitive and accurate identification of g...
Machine learning analysis of gene expression reveals TP53 Mutant-like AML with wild type TP53 and poor prognosis
Machine learning analysis of gene expression reveals TP53 Mutant-like AML with wild type TP53 and poor prognosis
TP53 mutations (TP53Mut) define the most rapidly fatal AML subtype [1, 2] (Supplementary Fig. S1A). We used AML datasets (...