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Sustained, complete response to pexidartinib in a patient with CSF1R‐mutated Erdheim–Chester disease
Sustained, complete response to pexidartinib in a patient with CSF1R‐mutated Erdheim–Chester disease
Abstract Erdheim–Chester disease (ECD) is a histiocytic neoplasm that predominantly harbors mitogen-activated prote...
Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3‐ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party/European society of blood and marrow transplantation
Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3‐ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party/European society of blood and marrow transplantation
Abstract FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutational status is a pivotal prognosticator i...
Impact of achieving a complete response to initial therapy of multiple myeloma and predictors of subsequent outcome
Impact of achieving a complete response to initial therapy of multiple myeloma and predictors of subsequent outcome
Abstract Achievement of a complete response (CR) in multiple myeloma (MM) correlates with improvement in survival outcomes...
The insertion site is the main risk factor for central venous catheter‐related complications in patients with hematologic malignancies
The insertion site is the main risk factor for central venous catheter‐related complications in patients with hematologic malignancies
Abstract Central venous catheters (CVC) placed either via the internal jugular vein (IJV) or the subclavian vein (SCV) are...
HLA 1–3 antigen‐mismatched related peripheral blood stem cells transplantation using low‐dose antithymocyte globulin versus unrelated cord blood transplantation
HLA 1–3 antigen‐mismatched related peripheral blood stem cells transplantation using low‐dose antithymocyte globulin versus unrelated cord blood transplantation
Abstract Little information is available regarding whether unrelated cord blood transplantation (CBT) or an HLA 1–3...
Gilteritinib Clinical Activity in Relapsed/Refractory FLT3 Mutated AML Previously Treated with FLT3 inhibitors
Gilteritinib Clinical Activity in Relapsed/Refractory FLT3 Mutated AML Previously Treated with FLT3 inhibitors
Abstract Gilteritinib is approved for the treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML) with a FLT3-...
Improved Outcomes Among Newly Diagnosed Patients with FLT3‐ITD Mutated AML Treated with Contemporary Therapy: Revisiting the ELN Adverse Risk Classification
Improved Outcomes Among Newly Diagnosed Patients with FLT3‐ITD Mutated AML Treated with Contemporary Therapy: Revisiting the ELN Adverse Risk Classification
Abstract Mutations in in fms-like tyrosine kinase 3 (FLT3) gene are common genomic alterations in acute myeloid leukemia (...
TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins
TLR8/TLR7 dysregulation due to a novel TLR8 mutation causes severe autoimmune hemolytic anemia and autoinflammation in identical twins
Abstract Our study presents a novel germline c.1715G>T (p.G572V) mutation in the gene encoding Toll-like receptor 8 (TL...
Voxelotor Use in Adults with Sickle Cell Disease in a Real‐World Setting
Voxelotor Use in Adults with Sickle Cell Disease in a Real‐World Setting
Corresponding Author Susanna A. Curtis Division of Hematol...
The clinical course and life expectancy of patients with multiple myeloma who discontinue their first daratumumab‐containing line of therapy
The clinical course and life expectancy of patients with multiple myeloma who discontinue their first daratumumab‐containing line of therapy
Based on its efficacy in clinical trials, daratumumab has become an integral part of the treatment of multiple myeloma (MM...
Thrombomodulin and multiorgan failure in sickle cell anemia
Thrombomodulin and multiorgan failure in sickle cell anemia
Vascular endothelial dysfunction in sickle cell anemia (SCA) leads to acute and chronic organ complications.1 The vasculop...
Lymphocytopenia predicts shortened survival in myelodysplastic syndrome with ring sideroblasts (MDS‐RS) but not in MDS/MPN‐RS‐T
Lymphocytopenia predicts shortened survival in myelodysplastic syndrome with ring sideroblasts (MDS‐RS) but not in MDS/MPN‐RS‐T
Corresponding Author Ayalew Tefferi Division of Hematology...
Landscape and clinical significance of long non‐coding RNAs involved in multiple myeloma expressed fusion transcripts
Landscape and clinical significance of long non‐coding RNAs involved in multiple myeloma expressed fusion transcripts
Christopher E. Mason PhD Division of Hematology/Oncology, Dept. of Medicine, We...
Increased blood viscosity and red blood cell aggregation in patients with COVID‐19
Increased blood viscosity and red blood cell aggregation in patients with COVID‐19
Abstract The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability, and aggregation in ...
Continuous treatment with Ibrutinib in 100 untreated patients with TP53 disrupted chronic lymphocytic leukemia: A real‐life campus CLL study
Continuous treatment with Ibrutinib in 100 untreated patients with TP53 disrupted chronic lymphocytic leukemia: A real‐life campus CLL study
Disruption of the TP53 gene, including 17p13 deletion (17p-) and/or TP53 gene mutation (TP53m), can be found in 8%–10% of ...
A multicenter, retrospective study of accelerated venetoclax ramp‐up in patients with relapsed/refractory chronic lymphocytic leukemia
A multicenter, retrospective study of accelerated venetoclax ramp‐up in patients with relapsed/refractory chronic lymphocytic leukemia
Corresponding Author Matthew S. Davids MD, MMSc Department...
Thrombomodulin and Multi‐Organ Failure in Sickle Cell Anemia
Thrombomodulin and Multi‐Organ Failure in Sickle Cell Anemia
Corresponding Author Santosh L. Saraf MD Division of Hemat...
Patient‐focused inquiry on Hydroxyurea Therapy Adherence and Reasons for Discontinuation in Adults with Sickle Cell Disease
Patient‐focused inquiry on Hydroxyurea Therapy Adherence and Reasons for Discontinuation in Adults with Sickle Cell Disease
This article has been accepted for publication and undergone full peer review but has not been through the copy...
Tocilizumab for severe acute chest syndrome in a child with sickle cell disease and dramatically high interleukin‐6 values in endotracheal and pleural fluids
Tocilizumab for severe acute chest syndrome in a child with sickle cell disease and dramatically high interleukin‐6 values in endotracheal and pleural fluids
In September 2021, a 6-year-old boy of Chadian descent, followed in our sickle cell disease (SCD) referral center for a se...
Continous Treatment with Ibrutinib in 100 Untreated Patients with TP53 Disrupted Chronic Lymphocytic Leukemia. A Real‐Life Campus CLL Study
Continous Treatment with Ibrutinib in 100 Untreated Patients with TP53 Disrupted Chronic Lymphocytic Leukemia. A Real‐Life Campus CLL Study
Corresponding Author Livio Trentin MD Hematology and Clini...
Venetoclax combined with FLAG‐based chemotherapy induces an early and deep response in Mixed‐Phenotype‐Acute Leukemia
Venetoclax combined with FLAG‐based chemotherapy induces an early and deep response in Mixed‐Phenotype‐Acute Leukemia
Corresponding Author Olivier Spertini Service and Central ...
Sutimlimab, an investigational C1s inhibitor, effectively prevents exacerbation of hemolytic anemia in a patient with cold agglutinin disease undergoing major surgery
Sutimlimab, an investigational C1s inhibitor, effectively prevents exacerbation of hemolytic anemia in a patient with cold agglutinin disease undergoing major surgery
Cold agglutinins (CAs) are autoantibodies, usually of the IgM class, directed against surface proteins expressed on red bl...
Diagnosis and Management of New Onset Severe Coagulopathy During After‐Hours with Thromboelastography
Diagnosis and Management of New Onset Severe Coagulopathy During After‐Hours with Thromboelastography
This article has been accepted for publication and undergone full peer review but has not been through the co...
Risk of mortality from anemia and iron overload in nontransfusion‐dependent β‐thalassemia
Risk of mortality from anemia and iron overload in nontransfusion‐dependent β‐thalassemia
Ineffective erythropoiesis in patients with nontransfusion-dependent β-thalassemia (NTDT) leads to chronic anemia that doe...
Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection
Italian patients with hemoglobinopathies exhibit a 5‐fold increase in age‐standardized lethality due to SARS‐CoV‐2 infection
Since the beginning of the COVID-19 pandemic, concerns have been expressed worldwide for patients with hemoglobinopathies ...
Efficacy and Tolerability of Once‐Weekly Selinexor, Bortezomib, and Dexamethasone in Comparison with Standard Twice‐Weekly Bortezomib and Dexamethasone in Previously Treated Multiple Myeloma with Renal Impairment: Subgroup Analysis from the BOSTON Study
Efficacy and Tolerability of Once‐Weekly Selinexor, Bortezomib, and Dexamethasone in Comparison with Standard Twice‐Weekly Bortezomib and Dexamethasone in Previously Treated Multiple Myeloma with Renal Impairment: Subgroup Analysis from the BOSTON Study
This article has been accepted for publication and undergone full peer review but has not been through the co...
Risk factors for severe COVID‐19 in hospitalized sickle cell disease patients: a study of 319 patients in France
Risk factors for severe COVID‐19 in hospitalized sickle cell disease patients: a study of 319 patients in France
French Sickle Cell Referral Center Internal Medicine Department, Georges Pompid...
A comprehensive platelet expression atlas (PEA) resource and platelet transcriptome landscape
A comprehensive platelet expression atlas (PEA) resource and platelet transcriptome landscape
Platelets are small circulating anucleate cells and play key roles in hemostasis, wound healing, and disease progression.1...
World Health Organization‐defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management
World Health Organization‐defined eosinophilic disorders: 2022 update on diagnosis, risk stratification, and management
Abstract Disease Overview The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematolo...
Tocilizumab for severe acute chest syndrome in a child with sickle cell disease and dramatically high IL‐6 values in endotracheal and pleural fluids
Tocilizumab for severe acute chest syndrome in a child with sickle cell disease and dramatically high IL‐6 values in endotracheal and pleural fluids
Corresponding Author Department of General Pediatrics and Pediatric Infectious ...
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