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Chimerism analysis by ABO blood group genotyping with digital droplet PCR
Chimerism analysis by ABO blood group genotyping with digital droplet PCR
Chimerism analysis is an important post-transplant assessment for allogeneic hematopoietic stem cell transplant (HCT) reci...
New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications
New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications
In 2024, the World Health Organization (WHO) launched a new classification of lymphoid neoplasms, a revision of the previo...
Graft CD8+ T cells for improving event-free survival after T cell-replete haploidentical stem cell transplantation in children with hematological malignancies
Graft CD8+ T cells for improving event-free survival after T cell-replete haploidentical stem cell transplantation in children with hematological malignancies
T cell-replete haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT) is a potentially curative therapy f...
Pseudo-Chediak–Higashi inclusions and Auer rods in a case of therapy-related acute monocytic leukemia
Pseudo-Chediak–Higashi inclusions and Auer rods in a case of therapy-related acute monocytic leukemia
Conflict of interest The author has no conflict of interest...
A 25-year clonal resurrection in adult T-cell leukemia-lymphoma relapse
A 25-year clonal resurrection in adult T-cell leukemia-lymphoma relapse
Here, we report a rare case of relapsed adult T-cell leukemia-lymphoma (ATL) with evidence of clonal relapse 26 y...
Recent advances in understanding the biology of follicular lymphoma
Recent advances in understanding the biology of follicular lymphoma
Follicular lymphoma (FL), the most common indolent B-cell lymphoma, develops over decades before manifesting as overt dise...
JSH practical guidelines for hematological malignancies, 2023: leukemia-6. Myelodysplastic syndromes (MDS)
JSH practical guidelines for hematological malignancies, 2023: leukemia-6. Myelodysplastic syndromes (MDS)
Conflict of interest YM has received per diem, including sp...
Temporal changes in corticosteroid dose during ibrutinib treatment in patients with cGVHD and pulmonary involvement
Temporal changes in corticosteroid dose during ibrutinib treatment in patients with cGVHD and pulmonary involvement
The GVH3001 study assessed the efficacy and safety of ibrutinib in Japanese patients with steroid-dependent or -refractory...
Understanding the intrinsic biology of diffuse large B-cell lymphoma: recent advances and future prospects
Understanding the intrinsic biology of diffuse large B-cell lymphoma: recent advances and future prospects
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoid tumor, and accounts for approximately 30–4...
Successful treatment of type I cryoglobulinemia with a combination of carfilzomib, cyclophosphamide, and dexamethasone: a case report and literature review
Successful treatment of type I cryoglobulinemia with a combination of carfilzomib, cyclophosphamide, and dexamethasone: a case report and literature review
Type I cryoglobulinemia is typically associated with hematological malignancies such as B-cell lymphomas and plasma cell n...
A case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria
A case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria
Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is a life-threatening complicat...
Long-term safety and efficacy of fostamatinib in Japanese patients with primary immune thrombocytopenia
Long-term safety and efficacy of fostamatinib in Japanese patients with primary immune thrombocytopenia
Fostamatinib had superior efficacy to a placebo and acceptable safety profiles for at least 1 year in a phase 3 study of J...
A practice-oriented genome-profiling study for acute myeloid leukemia using the novel HANDLE system: HM-screen-JAPAN02
A practice-oriented genome-profiling study for acute myeloid leukemia using the novel HANDLE system: HM-screen-JAPAN02
HM-SCREEN-Japan is a multicenter collaborative project in Japan to evaluate the clinical utility of a cancer genome panel ...
Current treatment approach and future perspectives in B cell lymphoma
Current treatment approach and future perspectives in B cell lymphoma
Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) represent the two major subtypes of mature B cell lymph...
Pneumatic tube transport-induced pseudohyperkalemia in patients with extreme leukocytosis: a retrospective study from a single medical center
Pneumatic tube transport-induced pseudohyperkalemia in patients with extreme leukocytosis: a retrospective study from a single medical center
Pseudohyperkalemia (falsely elevated serum potassium) must be distinguished from true hyperkalemia to avoid unnecessary tr...
Newly diagnosed multiple myeloma with bleeding and coagulation abnormalities caused by a thrombin-inhibiting substance
Newly diagnosed multiple myeloma with bleeding and coagulation abnormalities caused by a thrombin-inhibiting substance
Approximately 7% of patients with newly diagnosed multiple myeloma (MM) experience bleeding complications with varying cau...
Adult-onset severe paroxysmal cold hemoglobinuria after COVID-19 successfully treated with sutimlimab
Adult-onset severe paroxysmal cold hemoglobinuria after COVID-19 successfully treated with sutimlimab
Paroxysmal cold hemoglobinuria (PCH) is a form of cold autoimmune hemolytic anemia characterized by the presence of the Do...
Expansion effect of romiplostim on hematopoietic stem and progenitor cells versus thrombopoietin and eltrombopag
Expansion effect of romiplostim on hematopoietic stem and progenitor cells versus thrombopoietin and eltrombopag
Romiplostim, a thrombopoietin (TPO) receptor agonist, is a clinically approved drug that is clearly effective in reconstit...
Pathological landscape of tumor flare reaction to epcoritamab treatment
Pathological landscape of tumor flare reaction to epcoritamab treatment
Tumor flare reaction (TFR) is characterized by an increase in lesion size during immune-based therapy, often resembling di...
Precision medicine in AML: overcoming resistance
Precision medicine in AML: overcoming resistance
The development of molecularly targeted therapy for acute myeloid leukemia is progressing at an accelerated pace. Therapie...
Immunohistochemical differentiation of extramedullary acute myeloid leukemia from blastic plasmacytoid dendritic cell neoplasm
Immunohistochemical differentiation of extramedullary acute myeloid leukemia from blastic plasmacytoid dendritic cell neoplasm
We extend our deepest appreciation to the entire medical team at Yokohama Municipal Citizen's Hospital for their unwaverin...
Trametinib for a child with refractory Rosai–Dorfman–Destombes disease harboring a novel somatic mutation in MAP2K1
Trametinib for a child with refractory Rosai–Dorfman–Destombes disease harboring a novel somatic mutation in MAP2K1
Rosai–Dorfman–Destombes disease (RDD) is a rare histiocytosis characterized by accumulation of S100 +...
Efficacy and safety of recombinant porcine factor VIII in Japanese patients with acquired hemophilia A
Efficacy and safety of recombinant porcine factor VIII in Japanese patients with acquired hemophilia A
Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies inhibiting human factor VIII (hFVIII). Th...
CAR-T cell therapy in AML: recent progress and future perspectives
CAR-T cell therapy in AML: recent progress and future perspectives
Despite several small-molecule drugs that have revolutionized the current treatment strategy for acute myeloid leukemia (A...
Bilateral development of biclonal ocular adnexal marginal zone lymphoma at a 2-year interval
Bilateral development of biclonal ocular adnexal marginal zone lymphoma at a 2-year interval
Ocular adnexal marginal zone B-cell lymphoma (OAMZL) of the mucosa-associated lymphoid tissue is a distinct subtype of B-c...
A lower initial dose of bosutinib for patients with chronic myeloid leukemia patients resistant and/or intolerant to prior therapy: a single-arm, multicenter, phase 2 trial (BOGI trial)
A lower initial dose of bosutinib for patients with chronic myeloid leukemia patients resistant and/or intolerant to prior therapy: a single-arm, multicenter, phase 2 trial (BOGI trial)
Although bosutinib is generally safe and effective, drug-related toxicities (DRTs) such as diarrhea or increased transamin...
Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan
Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan
Autoimmune factor XIII (FXIII) deficiency (AiF13D) is a rare hemorrhagic disease. The anti-FXIII autoantibodies that cause...
Molecular pathophysiology of germline mutations in acute myeloid leukemia
Molecular pathophysiology of germline mutations in acute myeloid leukemia
Germline (GL) predisposition to acute myeloid leukemia (AML) has been established as an independent disease entity in the ...
Metabolic dependencies of acute myeloid leukemia stem cells
Metabolic dependencies of acute myeloid leukemia stem cells
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML c...
JSH practical guidelines for hematological malignancies, 2023: leukemia-3. Acute lymphoblastic leukemia/lymphoblastic lymphoma: ALL/LBL
JSH practical guidelines for hematological malignancies, 2023: leukemia-3. Acute lymphoblastic leukemia/lymphoblastic lymphoma: ALL/LBL
Conflict of interest KI has received per diem, including sp...
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