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The multifaceted repertoire of cellular reactive metabolites
Aye completed her undergraduate studies in chemistry at Oxford UK (2000–2004), and doctoral research in organic chemistry ...
Editorial overview: Glycobiology (2024)
Dr. Mia L Huang is a Professor in the Department of Chemistry at The Scripps Research Institute. She obtained her Ph.D. in...
Editorial: Unusual enzyme reactions in natural products biosynthesis
Taifo Mahmud received a B.S. (1989) and a professional pharmacy degree (1991) from University of North Sumatra, Indonesia,...
Editorial overview: Transforming intracellular delivery: Innovations in macromolecule transport
Jean-Philippe Pellois is a Professor in the Departments of Chemistry and Biochemistry & Biophysics at Texas A&M Un...
Recent developments in probing the levels and flux of selected organellar cations as well as organellar mechanosensitivity
Electrochemical gradients exist not only across the plasma membrane (PM) but also across membranes of organelles. Various ...
Ion transport across biological membranes
Robin S. Bon is Professor of Chemical Biology and Drug Discovery at the University of Leeds. His group uses chemical, mole...
Natural and artificial siderophores: Iron-based applications and beyond
Iron is an essential element in almost all living organisms, including bacteria, and serves as an enzymatic cofactor to ca...
Chemical tools to study and modulate glycan-mediated host-bacteria interactions
Glycans cover the surfaces of all cells, where they are poised to mediate a two-way discourse between bacteria and host ce...
Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition
Microbial metal homeostasis involves the acquisition, transport, storage, and utilization of metal ions that serve structu...
Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems
Eukaryogenesis was a foundational milestone in the origin of all complex life forms, including plants and mammals [1, 2, 3...
Creating and understanding new-to-nature chemistry
Virginia W. Cornish is the Helena Rubinstein Chair in the Department of Chemistry and a founding member of the Department ...
Probing ligand-induced local stability shifts: A sensitive approach to identify target proteins and binding sites at the proteomic scale
Proteins are the fundamental components of the cell and their three-dimensional structures have continuingly evolved to fi...
Recent advances in chemical proteomics for protein profiling and targeted degradation
Mass spectrometry (MS) has emerged as an indispensable tool for identifying and quantifying proteins in complex biological...
Recent advances in proximity labeling for chemical proteomics: Paving the way for in vivo applications
The integration of proximity labeling (PL) and advanced mass spectrometry-based proteomics is a robust framework for mappi...
Editorial overview: Editorial of molecular imaging
Dr. Schnermann is a Senior Investigator at the Center for Cancer Research in the National Cancer Institute, National Insti...
Chemical synthesis and biological functions of carbohydrates
Prof. You Yang obtained his Bachelor of Science in Chemistry from the University of Science and Technology of China (USTC)...
Mass spectrometry-based characterization of histone post-translational modification
In eukaryotes, the fundamental unit of chromatin is nucleosome, which contains approximately 147 base pairs of DNA wrapped...
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells
During mouse development, embryonic-stage germ cells (EGCs) make crucial fate decisions, with female EGCs embarking on mei...
Structural insights into transcriptional regulation by the helicase RECQL5
Structural insights into transcriptional regulation by the helicase RECQL5
Transcription poses a major challenge for genome stability. The RECQL5 helicase helps safeguard genome integrity and is th...
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation
Abnormally fast transcription elongation can lead to detrimental consequences such as transcription–replication coll...
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1
The golgins are long coiled-coil proteins involved in vesicular transport to the Golgi, a process that contributes to Golg...
A nanobody-based therapeutic targeting Nipah virus limits viral escape
A nanobody-based therapeutic targeting Nipah virus limits viral escape
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies....
Ferlin structures
Ferlins, such as dysferlin, myoferlin and otoferlin, are membrane proteins involved in calcium-dependent vesicle fusion, a...
Structure-guided molecular glues
Targeted protein degradation is a proven paradigm for advancing the fields of drug discovery, biochemical regulatory netwo...
Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Multiple myeloma (MM) is a highly malignant hematological tumor with a low overall survival rate, making the identificatio...
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
This study aims to investigate the impact of silibinin (SILI) on the expression of the Lipin-1 and Lipin-2 genes during wa...
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
We aimed to identify circRNA as a biomarker in non-small cell lung cancer (NSCLC) and explore the underlying mechanism. ci...
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
Cardiovascular diseases (CVD) are intricately linked to vascular dysfunction, with growing evidence implicating particulat...
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Authors and AffiliationsCellular Therapy and Stem Cell Production Application and Research Center (ESTEM), Eskisehir Osman...
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Aging is frequently associated with dysregulated lipid metabolism, while exercise may improve metabolic health, a process ...
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