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Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells
Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells
During mouse development, embryonic-stage germ cells (EGCs) make crucial fate decisions, with female EGCs embarking on mei...
Structural insights into transcriptional regulation by the helicase RECQL5
Structural insights into transcriptional regulation by the helicase RECQL5
Transcription poses a major challenge for genome stability. The RECQL5 helicase helps safeguard genome integrity and is th...
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation
Abnormally fast transcription elongation can lead to detrimental consequences such as transcription–replication coll...
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1
The golgins are long coiled-coil proteins involved in vesicular transport to the Golgi, a process that contributes to Golg...
A nanobody-based therapeutic targeting Nipah virus limits viral escape
A nanobody-based therapeutic targeting Nipah virus limits viral escape
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies....
Ferlin structures
Ferlins, such as dysferlin, myoferlin and otoferlin, are membrane proteins involved in calcium-dependent vesicle fusion, a...
Structure-guided molecular glues
Targeted protein degradation is a proven paradigm for advancing the fields of drug discovery, biochemical regulatory netwo...
Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Multiple myeloma (MM) is a highly malignant hematological tumor with a low overall survival rate, making the identificatio...
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
This study aims to investigate the impact of silibinin (SILI) on the expression of the Lipin-1 and Lipin-2 genes during wa...
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
We aimed to identify circRNA as a biomarker in non-small cell lung cancer (NSCLC) and explore the underlying mechanism. ci...
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
Cardiovascular diseases (CVD) are intricately linked to vascular dysfunction, with growing evidence implicating particulat...
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Authors and AffiliationsCellular Therapy and Stem Cell Production Application and Research Center (ESTEM), Eskisehir Osman...
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Aging is frequently associated with dysregulated lipid metabolism, while exercise may improve metabolic health, a process ...
Structural Mechanisms Driving the Selective Efficacy of Oxamniquine against and
Structural Mechanisms Driving the Selective Efficacy of Oxamniquine against and
Oxamniquine (OXA) exhibits selective efficacy against different Schistosoma species, with the highest activity observed in...
Structural and Energetic Insights into the Binding of - and -Arginine Analogs with Neuropilin-1 (NRP1): Molecular Docking, Molecular Dynamics and DFT Calculations
Structural and Energetic Insights into the Binding of - and -Arginine Analogs with Neuropilin-1 (NRP1): Molecular Docking, Molecular Dynamics and DFT Calculations
Neuropilin-1 (NRP1) is a transmembrane glycoprotein that binds numerous ligands, including vascular endothelial growth fac...
Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review
Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review
Deep vein thrombosis is an acute medical condition, and the molecular basis of this etiology will be crucial in the discov...
A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development
A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development
Acetyl-CoA Synthetase 2 (ACSS2) has emerged as a new target for anticancer development owing to its high expression in var...
Correction: Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway
Correction: Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway
Correction to: Cell Biochemistry and Biophysics (2025) 83:1097–1104; https://doi.org/...
Macrophage Polarization-Based Analysis of the Role of the FOXM1/KIF20A Axis in Breast Cancer Metastasis
Macrophage Polarization-Based Analysis of the Role of the FOXM1/KIF20A Axis in Breast Cancer Metastasis
To investigate the potential molecular processes underlying the function of forkhead box M1 (FOXM1)-mediated macrophage po...
ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways
ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways
Alzheimer’s disease is defined pathologically by the irregular buildup of senile plaques, neurofibrillary tangles, a...
Synergistic Enhancement of Apo2L/TRAIL and DR4-Induced Apoptosis by Arsenic Trioxide in Triple-Negative Breast Cancer Cells: A Comparison to Conventional Chemotherapy
Synergistic Enhancement of Apo2L/TRAIL and DR4-Induced Apoptosis by Arsenic Trioxide in Triple-Negative Breast Cancer Cells: A Comparison to Conventional Chemotherapy
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking hormonal and HER2 receptors, making it highly resist...
Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies
Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies
The rising prevalence of diabetes as a major non-communicable disease underscores the critical need for effective anti-dia...
Computational Drug Repurposing Screening Targeting Profibrotic Cytokine in Acute Respiratory Distress Syndrome
Computational Drug Repurposing Screening Targeting Profibrotic Cytokine in Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a severe lung disease with a high fatality rate and few treatment options. T...
Elucidating the Phytochemical, Antibacterial, and Hepatoprotective Effects of Leaf Extract Against Liver Injury in an Animal Model
Elucidating the Phytochemical, Antibacterial, and Hepatoprotective Effects of Leaf Extract Against Liver Injury in an Animal Model
Elaeagnus umbellata, commonly known as autumn olive, is considered a medicinal plant of high value and belongs to the Elae...
Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity
Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease. Glycyrrhiza pallidiflora polysaccharide (GPP) is an i...
Vertical displacement of the approximated body center of mass during typical daily activities: A transition-based complementary filter method using barometric and inertial data
Available online 4 May 2025, 112711Author links open overlay panel, , , , AbstractBy monitoring the movement of the body’s...
A novel method for brain aneurysms computed fluid dynamics analysis after flow diverter stent implantation based on micro-computed tomography reconstruction
Volume 186, June 2025, 112634Author links open overlay panel, , , , , , AbstractFlow diverter stents are now increasingly ...
Automatic video analysis of countermovement jump performance using a single uncalibrated camera
Volume 186, June 2025, 112695Author links open overlay panel, , , AbstractThe countermovement jump (CMJ) assessment is wid...
Differences in lower limb kinematics and kinetics between individuals with posterior tibial tendon dysfunction and healthy controls during step-up and step-down tasks
Posterior tibial tendon dysfunction (PTTD) is a debilitating condition with multifactorial etiologies that leads to functi...
Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts
Vascular grafts are used to restore or augment blood flow in cases of reduced or absent perfusion. Synthetic grafts have b...
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