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Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Gene Expression Profiling Identifies CAV1, CD44, and TFRC as Potential Diagnostic Markers and Therapeutic Targets for Multiple Myeloma
Multiple myeloma (MM) is a highly malignant hematological tumor with a low overall survival rate, making the identificatio...
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
Investigating Network and Experimental Effect of Silibinin on Lipin-1 and Lipin-2 Gene Expression during Ischemia-reperfusion of the Liver in Rats
This study aims to investigate the impact of silibinin (SILI) on the expression of the Lipin-1 and Lipin-2 genes during wa...
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer
We aimed to identify circRNA as a biomarker in non-small cell lung cancer (NSCLC) and explore the underlying mechanism. ci...
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
PM Induced Vascular and Myocardial Calcification Impairs Ischemia-reperfusion Tolerance via Mitochondrial Dysregulation
Cardiovascular diseases (CVD) are intricately linked to vascular dysfunction, with growing evidence implicating particulat...
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Correction: In vitro Chondrogenic Induction Promotes the Expression Level of IL-10 via the TGF-β/SMAD and Canonical Wnt/β-catenin Signaling Pathways in Exosomes Secreted by Human Adipose Tissue-derived Mesenchymal Stem Cells
Authors and AffiliationsCellular Therapy and Stem Cell Production Application and Research Center (ESTEM), Eskisehir Osman...
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT
Aging is frequently associated with dysregulated lipid metabolism, while exercise may improve metabolic health, a process ...
Structural Mechanisms Driving the Selective Efficacy of Oxamniquine against and
Structural Mechanisms Driving the Selective Efficacy of Oxamniquine against and
Oxamniquine (OXA) exhibits selective efficacy against different Schistosoma species, with the highest activity observed in...
Structural and Energetic Insights into the Binding of - and -Arginine Analogs with Neuropilin-1 (NRP1): Molecular Docking, Molecular Dynamics and DFT Calculations
Structural and Energetic Insights into the Binding of - and -Arginine Analogs with Neuropilin-1 (NRP1): Molecular Docking, Molecular Dynamics and DFT Calculations
Neuropilin-1 (NRP1) is a transmembrane glycoprotein that binds numerous ligands, including vascular endothelial growth fac...
Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review
Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review
Deep vein thrombosis is an acute medical condition, and the molecular basis of this etiology will be crucial in the discov...
A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development
A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development
Acetyl-CoA Synthetase 2 (ACSS2) has emerged as a new target for anticancer development owing to its high expression in var...
Correction: Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway
Correction: Cinnamaldehyde Alleviates Alveolar Epithelial Cell Injury in ALI by Inhibiting the CaMKII Pathway
Correction to: Cell Biochemistry and Biophysics (2025) 83:1097–1104; https://doi.org/...
Macrophage Polarization-Based Analysis of the Role of the FOXM1/KIF20A Axis in Breast Cancer Metastasis
Macrophage Polarization-Based Analysis of the Role of the FOXM1/KIF20A Axis in Breast Cancer Metastasis
To investigate the potential molecular processes underlying the function of forkhead box M1 (FOXM1)-mediated macrophage po...
ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways
ABT263 Ameliorates Cellular Senescence, Aβ-Dependent Pathology and Cognitive Decline in Aged APP/PS1 Mice via Regulating PI3K/AKT/GSK-3β Pathways
Alzheimer’s disease is defined pathologically by the irregular buildup of senile plaques, neurofibrillary tangles, a...
Synergistic Enhancement of Apo2L/TRAIL and DR4-Induced Apoptosis by Arsenic Trioxide in Triple-Negative Breast Cancer Cells: A Comparison to Conventional Chemotherapy
Synergistic Enhancement of Apo2L/TRAIL and DR4-Induced Apoptosis by Arsenic Trioxide in Triple-Negative Breast Cancer Cells: A Comparison to Conventional Chemotherapy
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking hormonal and HER2 receptors, making it highly resist...
Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies
Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies
The rising prevalence of diabetes as a major non-communicable disease underscores the critical need for effective anti-dia...
Computational Drug Repurposing Screening Targeting Profibrotic Cytokine in Acute Respiratory Distress Syndrome
Computational Drug Repurposing Screening Targeting Profibrotic Cytokine in Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a severe lung disease with a high fatality rate and few treatment options. T...
Elucidating the Phytochemical, Antibacterial, and Hepatoprotective Effects of Leaf Extract Against Liver Injury in an Animal Model
Elucidating the Phytochemical, Antibacterial, and Hepatoprotective Effects of Leaf Extract Against Liver Injury in an Animal Model
Elaeagnus umbellata, commonly known as autumn olive, is considered a medicinal plant of high value and belongs to the Elae...
Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity
Polysaccharide Ameliorates DSS-Induced Colitis by Protecting Intestinal Barrier Integrity
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease. Glycyrrhiza pallidiflora polysaccharide (GPP) is an i...
Molecular Mechanism of Cynodon dactylon Phytosterols Targeting MAPK3 and PARP1 to Combat Epithelial Ovarian Cancer: A Multifaceted Computational Approach
Molecular Mechanism of Cynodon dactylon Phytosterols Targeting MAPK3 and PARP1 to Combat Epithelial Ovarian Cancer: A Multifaceted Computational Approach
Epithelial Ovarian Cancer (EOC) presents a global health concern, necessitating the development of innovative therapeutic ...
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer
TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer
Triple-negative breast cancer (TNBC) is characterized by a grim prognosis and numerous challenges. The objective of our st...
Lovastatin Combination Therapy Increases the Survival and Proliferation of Rat Bone Marrow-Derived Mesenchymal Stem Cells Against the Inflammatory Activity of Lipopolysaccharide
Lovastatin Combination Therapy Increases the Survival and Proliferation of Rat Bone Marrow-Derived Mesenchymal Stem Cells Against the Inflammatory Activity of Lipopolysaccharide
Oxidative stress hurts the survival of transplanted mesenchymal stem cells (MSCs). Lipopolysaccharide (LPS) preconditionin...
Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives
Molecular Understanding and Pharmacological Potency of Plant-Derived Compounds in Colorectal Cancer (CRC): A Critical Analysis and Future Perspectives
Colorectal cancer (CRC) is the main driver of fatality and the 3rd most often determined malignancy. Despite advances in d...
Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway
Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway
Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease with high death rates. Aucubin is an ...
Smart Dressings and Their Applications in Chronic Wound Management
Smart Dressings and Their Applications in Chronic Wound Management
During chronic wound healing, the inflammatory phase can endure for extended periods, heavily impeding or halting the proc...
miRNAs that regulate apoptosis in breast cancer and cervical cancer
miRNAs that regulate apoptosis in breast cancer and cervical cancer
In today’s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a l...
Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway
Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway
As a common inflammatory bowel disease, ulcerative colitis (UC) is featured with inflammation, oxidative damage, and the i...
In Silico Investigation against Inhibitors of Alpha-Amylase Using Structure-based Screening, Molecular Docking, and Molecular Simulations Studies
In Silico Investigation against Inhibitors of Alpha-Amylase Using Structure-based Screening, Molecular Docking, and Molecular Simulations Studies
Type-II diabetes mellitus is a chronic disorder that results from fluctuations in the glucose level leading to hyperglycem...
Development and Enhancement of PCF-based Sensors for Terahertz-frequency Region Breast Cancer Cell Detection
Development and Enhancement of PCF-based Sensors for Terahertz-frequency Region Breast Cancer Cell Detection
In today’s medical research, breast cancer is a severe problem, so it is imperative to develop a reliable and effici...
The Impact of the VEGF/VEGFR2/PI3K/AKT Signaling Axis on the Proliferation and Migration Abilities of Human Dental Pulp Stem Cells
The Impact of the VEGF/VEGFR2/PI3K/AKT Signaling Axis on the Proliferation and Migration Abilities of Human Dental Pulp Stem Cells
The potential therapeutic benefits of human dental pulp stem cells (HDPSCs) in dental regenerative medicine have been demo...
Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells
Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells
Acute Myeloid Leukemia (AML) is a hematological cancer that frequently presents with a range of side effects and drug resi...
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