Aucubin Alleviates Chronic Obstructive Pulmonary Disease by Activating Nrf2/HO-1 Signaling Pathway

Labaki, W. W., & Rosenberg, S. R. (2020). Chronic obstructive pulmonary disease. Annals of Internal Medicine, 173(3), Itc17–itc32.

Article  PubMed  Google Scholar 

Dean, E. (2017). Chronic obstructive pulmonary disease. Nursing Older People, 29(4), 12.

Article  PubMed  Google Scholar 

Batura-Gabryel, H., & Grabicki, M. (2014). [Chronic obstructive pulmonary disease and cardiovascular diseases-‘cardiopulmonary continuum’]. Pneumonol Alergol Pol, 82(6), 590–596.

PubMed  Google Scholar 

Horodinschi, R. N. et al. (2020). Heart failure and chronic obstructive pulmonary disease: a review. Acta Cardiologica, 75(2), 97–104.

Article  PubMed  Google Scholar 

Postma, D. S., Bush, A., & van den Berge, M. (2015). Risk factors and early origins of chronic obstructive pulmonary disease. Lancet, 385(9971), 899–909.

Article  PubMed  Google Scholar 

Salvi, S. (2014). Tobacco smoking and environmental risk factors for chronic obstructive pulmonary disease. Clinics in Chest Medicine, 35(1), 17–27.

Article  PubMed  Google Scholar 

Goel, R. et al. (2018). Effect of charcoal in cigarette filters on free radicals in mainstream smoke. Chemical Research in Toxicology, 31(8), 745–751.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teke, T. et al. (2012). Cigarette smoke and bleomycin-induced pulmonary oxidative stress in rats. Experimental and Therapeutic Medicine, 4(1), 121–124.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, T. et al. (2020). Trans-4,4’-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. Free Radical Biology and Medicine, 152, 525–539.

Article  CAS  PubMed  Google Scholar 

Guiedem, E. et al. (2018). Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD. BMC Research Notes, 11(1), 192.

Article  PubMed  PubMed Central  Google Scholar 

Vandivier, R. W., & Ghosh, M. (2017). Understanding the relevance of the mouse cigarette smoke model of COPD: Peering through the smoke. American Journal of Respiratory Cell and Molecular Biology, 57(1), 3–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh, M. et al. (2015). Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer. PLoS One, 10(4), e0122823.

Article  PubMed  PubMed Central  Google Scholar 

Zhu, M. Q., & Sun, R. C. (2018). Eucommia ulmoides Oliver: A potential feedstock for bioactive products. Journal of Agricultural and Food Chemistry, 66(22), 5433–5438.

Article  CAS  PubMed  Google Scholar 

Huang, L. et al. (2021). Traditional application and modern pharmacological research of Eucommia ulmoides Oliv. Chinese Medicine, 16(1), 73.

Article  PubMed  PubMed Central  Google Scholar 

Zeng, X., Guo, F., & Ouyang, D. (2020). A review of the pharmacology and toxicology of aucubin. Fitoterapia, 140, 104443.

Article  CAS  PubMed  Google Scholar 

Zheng, J. et al. (2012). [Enzymatic extraction and antibacterial activity of aucubin from Eucommia ulmoides leaves]. Zhong Yao Cai, 35(2), 304–306.

CAS  PubMed  Google Scholar 

Wang, B. W. et al. (2019). Aucubin protects chondrocytes against IL-1β-induced apoptosis in vitro and inhibits osteoarthritis in mice model. Drug Design, Development and Therapy, 13, 3529–3538.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, H. et al. (2020). Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury. Journal of Neuroinflammation, 17(1), 188.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang, Z. et al. (2018). Aucubin protects against myocardial infarction-induced cardiac remodeling via nNOS/NO-regulated oxidative stress. xidative Medicine and Cellular Longevity, 2018, 4327901.

Google Scholar 

Pan, B. et al. (2019). [Aucubin alleviates lipopolysaccharide-induced acute lung injury in mice].Zhong Nan Da Xue Xue Bao Yi Xue Ban, 44(2), 128–133.

PubMed  Google Scholar 

Ma, Q. (2013). Role of nrf2 in oxidative stress and toxicity. Annual Review of Pharmacology and Toxicology, 53, 401–426.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bellezza, I. et al. (2018). Nrf2-Keap1 signaling in oxidative and reductive stress. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(5), 721–733.

Article  CAS  PubMed  Google Scholar 

Loboda, A. et al. (2016). Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cellular and Molecular Life Sciences, 73(17), 3221–3247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang, C. Y. et al. (2020). Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 pathways, and suppressing oxidative stress-mediated ER stress-induced apoptosis and autophagy. Nutrients, 12(6), 1742.

Li, J. et al. (2021). Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. Journal of Translational Medicine, 19(1), 96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang, X. et al. (2020). Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. Respiratory Research, 21(1), 95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh, A. et al. (2016). Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-deficient NSCLC tumors. ACS Chemical Biology, 11(11), 3214–3225.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, X. et al. (2022). Dihydroquercetin suppresses cigarette smoke induced ferroptosis in the pathogenesis of chronic obstructive pulmonary disease by activating Nrf2-mediated pathway. Phytomedicine, 96, 153894.

Article  CAS  PubMed  Google Scholar 

Zhang, Y. et al. (2024). Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis. Journal of Cardiothoracic Surgery, 19(1), 58.

Article  PubMed  PubMed Central  Google Scholar 

Guan, R. et al. (2020). Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway. Redox Biology, 28, 101356.

Article  CAS  PubMed  Google Scholar 

Qiu, Y. L. et al. (2018). Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways. Biomedicine & Pharmacotherapy, 106, 192–199.

Article  CAS  Google Scholar 

Yang, Y. et al. (2017). Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice. Life Science, 189, 44–51.

Article  CAS  Google Scholar 

Liu, Y. et al. (2021). Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo. Chinese Medicine, 16(1), 127.

Comments (0)

No login
gif