Chen, X. Q., & Mobley, W. C. (2019). Alzheimer disease pathogenesis: Insights from molecular and cellular biology studies of oligomeric abeta and tau species. Frontiers in Neuroscience, 13, 659.
Article PubMed PubMed Central Google Scholar
(2023). 2023 Alzheimer’s disease facts and figures. Alzheimers Dement 19, 1598–1695.
Griffiths, J., & Grant, S. G. N. (2023). Synapse pathology in Alzheimer’s disease. Seminars in Cell & Developmental Biology, 139, 13–23.
Kurkinen, M., Fulek, M., Fulek, K., Beszlej, J. A., Kurpas, D., & Leszek, J. (2023). The amyloid cascade hypothesis in Alzheimer’s disease: Should we change our thinking? Biomolecules, 13, 453.
Article CAS PubMed PubMed Central Google Scholar
Chong, F. P., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2018). Tau proteins and tauopathies in Alzheimer’s disease. Cellular and Molecular Neurobiology, 38, 965–980.
Aschenbrenner, A. J., Crawford, J. L., Peelle, J. E., Fagan, A. M., Benzinger, T. L. S., Morris, J. C., Hassenstab, J., & Braver, T. S. (2023). Increased cognitive effort costs in healthy aging and preclinical Alzheimer’s disease. Psychology and Aging, 38(5), 428–442.
Article PubMed PubMed Central Google Scholar
Bai, R., & Dong, W. (2021). Trends in mortality rates for Alzheimer’s disease and other dementias over 30 years in China. American Journal of Alzheimer’s Disease and Other Dementias, 36, 15333175211044884.
Article PubMed PubMed Central Google Scholar
Li, F., Qin, W., Zhu, M., & Jia, J. (2021). Model-based projection of dementia prevalence in China and worldwide: 2020–2050. Journal of Alzheimer’s Disease: JAD, 82, 1823–1831.
He, S., & Sharpless, N. E. (2017). Senescence in health and disease. Cell, 169, 1000–1011.
Article CAS PubMed PubMed Central Google Scholar
Lau, V., Ramer, L., & Tremblay, M. E. (2023). An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease. Nature Communications, 14, 1670.
Article CAS PubMed PubMed Central Google Scholar
Wissler Gerdes, E. O., Zhu, Y., Weigand, B. M., Tripathi, U., Burns, T. C., Tchkonia, T., & Kirkland, J. L. (2020). Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases. International Review of Neurobiology, 155, 203–234.
Article PubMed PubMed Central Google Scholar
Ohtani, N. (2022). The roles and mechanisms of senescence-associated secretory phenotype (SASP): Can it be controlled by senolysis? Inflammation and Regeneration, 42, 11.
Article CAS PubMed PubMed Central Google Scholar
Malaquin, N., Tu, V., & Rodier, F. (2019). Assessing functional roles of the senescence-associated secretory phenotype (SASP). Methods in Molecular Biology, 1896, 45–55.
Article CAS PubMed Google Scholar
Larsen, C. J. (2004). pRB, p53, p16INK4a, senescence and malignant transformation. Bulletin Du Cancer, 91, 399–402.
Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000). Genes involved in senescence and immortalization. Current Opinion in Cell Biology, 12, 705–709.
Article CAS PubMed Google Scholar
Simboeck, E., & Di, L. (2013). Croce, p16INK4a in cellular senescence. Aging (Albany NY), 5, 590–591.
Wagner, K. D., & Wagner, N. (2022). The senescence markers p16INK4A, p14ARF/p19ARF, and p21 in organ development and homeostasis. Cells, 11, 1966.
Article CAS PubMed PubMed Central Google Scholar
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015). The role of oxidative stress in neurodegenerative diseases. Experimental Neurobiology, 24, 325–340.
Article PubMed PubMed Central Google Scholar
Geng, Y. Q., Guan, J. T., Xu, X. H., & Fu, Y. C. (2010). Senescence-Associated Beta-Galactosidase Activity Expression in Aging Hippocampal Neurons. Biochemical and Biophysical Research Communications, 396, 866–869.
Article CAS PubMed Google Scholar
Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: A translational perspective. EBioMedicine, 21, 21–28.
Article PubMed PubMed Central Google Scholar
Safwan-Zaiter, H., Wagner, N., Michiels, J. F., & Wagner, K. D. (2022). Dynamic spatiotemporal expression pattern of the senescence-associated factor p16Ink4a in development and aging. Cells, 11, 541.
Article CAS PubMed PubMed Central Google Scholar
Barrera-Vázquez, O. S., Gómez-Verjan, J. C., & Magos-Guerrero, G. A. (2021). Chemoinformatic screening for the selection of potential senolytic compounds from natural products. Biomolecules, 11, 467.
Article PubMed PubMed Central Google Scholar
Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018). Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature, 562, 578–582.
Article CAS PubMed PubMed Central Google Scholar
Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., & Mattson, M. P. (2019). Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model. Nature Neuroscience, 22, 719–728.
Article CAS PubMed PubMed Central Google Scholar
Wyss-Coray, T. (2016). Ageing, neurodegeneration and brain rejuvenation. Nature, 539, 180–186.
Article CAS PubMed PubMed Central Google Scholar
Carmona, J. J., & Michan, S. (2016). Biology of healthy aging and longevity. Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion, 68, 7–16.
Itahana, K., Campisi, J., & Dimri, G. P. (2007). Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods in Molecular Biology, 371, 21–31.
Article CAS PubMed Google Scholar
Biran, A., Zada, L., Abou Karam, P., Vadai, E., Roitman, L., Ovadya, Y., Porat, Z., & Krizhanovsky, V. (2017). Quantitative identification of senescent cells in aging and disease. Aging Cell, 16, 661–671.
Article CAS PubMed PubMed Central Google Scholar
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013). Proinflammatory cytokines, aging, and age-related diseases. Journal of the American Medical Directors Association, 14, 877–882.
Birch, J., & Gil, J. (2020). Senescence and the SASP: Many therapeutic avenues. Genes & Development, 34, 1565–1576.
Zhu, Y., Armstrong, J. L., Tchkonia, T., & Kirkland, J. L. (2014). Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Current Opinion in Clinical Nutrition and Metabolic Care, 17, 324–328.
Article CAS PubMed Google Scholar
Lee, S., Wang, E. Y., Steinberg, A. B., Walton, C. C., Chinta, S. J., & Andersen, J. K. (2021). A guide to senolytic intervention in neurodegenerative disease. Mechanisms of Ageing and Development, 200, 111585.
Comments (0)