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Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes
Zebrafish and cellular models of SELENON-Congenital myopathy exhibit novel embryonic and metabolic phenotypes
SELENON-Congenital Myopathy (SELENON-CM) is a rare congenital myopathy caused by mutations of the SELENON gene characteriz...
Generation of a novel mouse model of nemaline myopathy due to recurrent NEB exon 55 deletion
Generation of a novel mouse model of nemaline myopathy due to recurrent NEB exon 55 deletion
Biallelic pathogenic variants in the nebulin (NEB) gene lead to the congenital muscle disease nemaline myopathy. In-frame ...
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular ad...
Correction: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development
Correction: OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development
Marco Savarese and Bjarne Udd contributed equally to this work.Folkhälsan Research Center, Helsinki, FinlandAli Oghabian, ...
Pharmacology and macrophage modulation of HPGDS inhibitor PK007 demonstrate reduced disease severity in DMD-affected muscles of the mdx mouse model
Pharmacology and macrophage modulation of HPGDS inhibitor PK007 demonstrate reduced disease severity in DMD-affected muscles of the mdx mouse model
Duchenne Muscular Dystrophy (DMD) is an X-linked disease characterised by chronic inflammation, progressive muscle damage,...
Tim-3 promotes viral infection by suppressing the USP25-TRAF3-IRF7 signaling pathway
T-cell immunoglobulin and mucin domain 3 (Tim-3) is widely expressed on many immune cells including T cells and macrophage...
Breast cancer stem cells convert anti-tumor CD4+ T cells to pro-tumor T regulatory cells: Potential role of exosomal FOXP3
Emerging evidence indicates an inverse relationship between the percentage of regulatory T cells (Tregs) and poor prognosi...
In vitro ovarian tumor-conditioned CD163+ human macrophages retain phagocytic response to CD47 blockade
IntroductionCD163-expressing macrophages are abundant in ovarian cancer where they accelerate tumor growth and metastasis....
Nebulized mesenchymal stem cell-derived exosomes attenuate airway inflammation in a rat model of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by persistent airflow limitation and t...
Immunity in children: How does it begin?
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2025 Elsevier B.V., its licensors, an...
Transfer of bone marrow niche-residential regulatory T cells ameliorates experimental colitis
Treg infusion has been drawing attention as a promising approach to control inflammatory diseases or autoimmune disorders ...
Characterization of Lysate from NK-92 cells and its potential use as immunotherapeutic modality
Using lysate from prokaryotic or eukaryotic cells for medical and laboratory purposes is not a new concept. Lysate from hu...
Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na+/K+-ATPase-mediated mitophagy
Spinal cord injury (SCI), a severe central nervous system disorder, often results in motor and sensory dysfunction, causin...
Apelin-13 enhances neurofunctional recovery and suppresses neuroinflammation via the SIRT1/NF-κB axis in ischemic stroke
Stroke is a leading cause of disability worldwide, with its epidemiology marked by a high incidence and prevalence, partic...
Divergent impact of endotoxin priming and endotoxin tolerance on macrophage responses to cancer cells
It is known that when primed with endotoxin, macrophages are more reactive and produce higher levels of inflammatory media...
Dexmedetomidine modulates peritoneal macrophage to attenuate lipopolysaccharide-induced inflammation
Dexmedetomidine's Potential: Dexmedetomidine (Dex), an α2-adrenergic receptor agonist, shows promise in modulating macroph...
USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy
Dendritic cells (DCs) are the fraction of immune cells that initiate immune responses in the body. Antigens are captured b...
METTL3 promotes infantile pneumonia-induced lung injury by the m6A-TBL1XR1-ACSL1 axis
Infantile pneumonia (IP) is an inflammation of the lungs caused by pathogens (such as bacteria and viruses) and other fact...
Immunology of familial chorea-acanthocytosis with presenting generalized tonic-clonic seizure: Blood cell study for early diagnosis and management
Chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS) are the progressive neurodegenerative diseases with the rare incide...
A new chimeric protein composed by T-cell epitopes from peroxidoxin and pyridoxal kinase proteins is protective against visceral leishmaniasis
Leishmaniasis is a neglected tropical disease complex caused by intracellular protozoan parasites that present an estimate...
MAPK14 drives Ferroptosis and immune dysfunction in pediatric Sepsis-induced acute lung injury
Sepsis is a life-threatening condition characterized by an excessive immune response to infection that leads to multiple o...
Novel and effective tandem CD38 and CD19 targeting CAR-T cells inhibit hematological tumor immune escape
The 2024 Breakthrough Prize in Life Sciences was awarded to Carl June and Michel Sadelain for genetically engineering T ce...
Role of CD44+CCR2+CD64−monocyte-derived macrophage in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of nasal cavity and sinus, affecting about 10 % of the adu...
Hyperoside suppresses NSCLC progression by inducing ATG13-mediated autophagy and apoptosis
Indispensable advancements regarding non-small cell lung cancer (NSCLC) treatment have been made in the last two decades [...
Aged mice-derived bronchial epithelial cells regulate Th17 cell differentiation in asthma via the MBD2-sICOSL axis
Asthma is often induced by T helper type 2 (Th2) cells, which promote infiltration of eosinophils. However, due to the het...
Selective CDK4 inhibition holds promise for breast cancer
Selective CDK4 inhibition holds promise for breast cancer
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Phase separation paints Xi with Xist
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Why resident microglial-like cells were missed in the peripheral nervous system
In a recent paper in Cell, Wu et al. described a novel peripheral nervous sy...
Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor
Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor
The State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, Ch...
Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex
Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex
In animals, AGO-clade Argonaute proteins utilize small interfering RNAs (siRNAs) as guides to recognize target with comple...
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