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IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
Chronic inflammation is well recognized as a key factor related to renal function deterioration in patients with diabetic ...
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Cardiovascular diseases (CVDs) continue to be a substantial global healthcare burden despite considerable progress in ther...
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy sup...
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
Particulate matter (PM) exposure has been proposed as one of the causes of steroid resistance. However, studies investigat...
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
This study seeks to elucidate the role and molecular mechanisms of IL-8 in nasal epithelial cell pyroptosis and its impact...
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized...
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury
Hyperoxia-induced brain injury is a severe neurological complication that is often accompanied by adverse long-term progno...
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Pericytes mediate neuroinflammation via Fli-1 in endotoxemia and sepsis in mice
Sepsis-associated encephalopathy (SAE) often results from neuroinflammation. Recent studies have shown that brain platelet...
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin–angiotensin–aldosterone system inhibitors
Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane...
The role of celastrol in inflammation and diseases
The role of celastrol in inflammation and diseases
Celastrol is one of the main active ingredients extracted from the plant Tripterygium wilfordii Hook F. A growing number o...
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars
Hypertrophic scar (HS) is a severe skin fibrosis. Transplanting stem cells carrying anti-fibrotic cytokine genes, like int...
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage
Lipopolysaccharide (LPS) induces sclerostin secretion by extracellular vesicle via TLR4/miR-92a-3p/PTEN/NF-κB signalling pathway in murine macrophage
Sclerostin (SOST) is traditionally regarded as an osteocyte-derived secreted glycoprotein that regulates bone mineralizati...
Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice
Selective phosphodiesterase 4 inhibitor roflumilast reduces inflammation and lung injury in models of betacoronavirus infection in mice
We aimed to understand the potential therapeutic and anti-inflammatory effects of the phosphodiesterase-4 (PDE4) inhibitor...
ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration
ASIC1a mediated nucleus pulposus cells pyroptosis and glycolytic crosstalk as a molecular basis for intervertebral disc degeneration
One of the etiologic components of degenerative spinal illnesses is intervertebral disc degeneration (IVDD), and the accom...
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues
The aberrant expression of α defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the d...
Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells
Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells
In skin lesions of atopic dermatitis (AD), a chronic inflammatory skin disease, mast cells beyond other immune cells are p...
Silicone breast implant-associated pathologies and T cell-mediated responses
Silicone breast implant-associated pathologies and T cell-mediated responses
Silicone breast implants elicit a foreign body response (FBR) defined by a complex cascade of various immune cells. Studie...
HMGB1: key mediator in digestive system diseases
HMGB1: key mediator in digestive system diseases
High Mobility Group Box 1 (HMGB1), a multifunctional non-histone protein, and its involvement in various physiological and...
Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
Structural Studies of Ion Channels: Achievements, Problems, and Perspectives
The superfamily of membrane proteins known as P-loop channels encompasses potassium, sodium, and calcium channels, as well...
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
Lipid-Mediated Adaptation of Proteins and Peptides in Cell Membranes
The paper overviews the results of computational studies of the molecular mechanisms underlying the adaptation of model ce...
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Alterations of Store-Operated Calcium Entry in Neurodegenerative Pathologies: History, Facts, and Prospects
Neurodegenerative diseases, along with cardiovascular and oncological pathologies, are one of the most acute problems of m...
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Mechanisms of Lipid-Mediated Regulation of the Pore-Forming Activity of Antimicrobial Agents: Studies on Planar Lipid Bilayers
Planar lipid bilayers are unique tools designed for modeling cell membranes and electrophysiological studies of ion channe...
Structure and Functions of the OTOP1 Proton Channel
Structure and Functions of the OTOP1 Proton Channel
OTOP1 belongs to the otopetrin family of membrane proteins that form proton channels in cells of diverse types. In mammals...
Evolutionary Choice between Cholesterol and Ergosterol
Evolutionary Choice between Cholesterol and Ergosterol
Sterol biosynthesis has evolved early in the history of eukaryotes. In most animals, as well as in primitive fungi, the ma...
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
Membrane-Dependent Reactions of Blood Coagulation: Classical View and State-of-the-Art Concepts
The complex mechanism called hemostasis evolved in living organisms to prevent blood loss when a blood vessel is damaged. ...
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Cell Membrane Cholesterol and Regulation of Cellular Processes: New and the Same Old Thing
Membranes of living cells, or biological membranes, are unique molecular systems in which the functioning of all molecules...
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Role of Membrane H+ Transport and Plasmalemma Excitability in Pattern Formation, Long-Distance Transport and Photosynthesis of Characean Algae
Illuminated giant cells of Characeae produce alternating areas with H+-pump activity and zones of high H+/OH– conduc...
Nexus between RNA conformational dynamics and functional versatility
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Empowering the molecular ruler techniques with unnatural base pair system to explore conformational dynamics of flaviviral RNAs
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Conformational penalties: New insights into nucleic acid recognition
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