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Synergy between microtubule and actin networks in centrosome positioning
Centrosome positioning is important for cellular function, but the exact forces and spatial distribution that underly accu...
Surveilling ribosome biogenesis
Eukaryotic ribosomal quality control degrades faulty ribosomal assemblies, but precise mechanisms to target defective pre-...
Grow up, beta cells
Mitochondrial impairment, particularly in beta cells, is closely associated with metabolic disorders such as type 2 diabet...
Light microscopy reporting for reproducibility
We announce a cross-journal pilot at Nature Portfolio journals with a goal of implementing standardized light and fluoresc...
Cytoplasmic control of spindle architecture
Cytoplasmic control of spindle architecture
Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by ...
Organelle conversations drive ferroptosis
Organelle conversations drive ferroptosis
Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research ha...
Crossover patterning through condensation and coarsening of pro-crossover factors
Crossover patterning through condensation and coarsening of pro-crossover factors
Meiotic recombination mixes genetic information from parental genomes, creating unique combinations of alleles. During mei...
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates
Recent studies exploring the underlying pathomechanisms of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disor...
[Neuroscience] Modeling Normal and Abnormal Circuit Development with Recurrent Neural Networks
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the mol...
[Physiology] Autophagy in Skeletal Muscle
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the mol...
[Cell Biology] Mechanochemical Principles of Epidermal Tissue Dynamics
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the mol...
[Science Education] Teaching School Genetics in the 2020s: Why "Naive" Mendelian Genetics Has to Go
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the mol...
[Molecular Biology] Oxidative Stress and DNA Damage at Telomeres
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the mol...
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
Sepsis is a severe systemic inflammatory syndrome and one of the leading causes of global morbidity and mortality. Preclin...
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Neuron–microglia communication through the fractalkine pathway is a critical factor mediating microglial proliferati...
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
Sepsis-induced acute lung injury (ALI) is a life-threatening condition with high mortality rates, and its underlying mecha...
Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis
Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis
Granulomatous mastitis (GM) is a form of non-lactational breast inflammation that is closely associated with autoimmune pr...
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway
This study investigates the effect and underlying mechanism of targeting SLC7A11 in mitigating dextran sulfate sodium (DSS...
Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury
Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury
Acute kidney injury (AKI) is a prevalent and critical clinical condition characterized by high morbidity and mortality. Re...
Nonstructural Protein 1 Mediates HMGB1 Release by Targeting Histone H1.0 After Respiratory Syncytial Virus Infection In Vivo and In Vitro
Nonstructural Protein 1 Mediates HMGB1 Release by Targeting Histone H1.0 After Respiratory Syncytial Virus Infection In Vivo and In Vitro
High mobility group box-1 (HMGB1) is implicated in airway inflammation during the late phase of respiratory syncytial viru...
Sodium–Glucose Cotransporter 2 Inhibitor Ameliorate Angiotensin II-Induced Hypertension and Vascular Injury by Upregulating FGF21
Sodium–Glucose Cotransporter 2 Inhibitor Ameliorate Angiotensin II-Induced Hypertension and Vascular Injury by Upregulating FGF21
Clinical trials have demonstrated Sodium-glucose cotransporter 2 inhibitors (SGLT2i) antihypertensive effects, yet their u...
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head
Glucocorticoids-induced osteonecrosis of the femoral head (GONFH) is characterized by progressive cartilage degeneration, ...
Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model
Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model
Allergen immunotherapy (AIT) is the only treatment that can alter the course of allergic diseases by inducing immune toler...
LncRNA SNHG7/miR-181b-5p/TLR4 Activates Inflammation And Promotes Pyroptosis Through NF-κB Signaling in Diabetic Nephropathy
LncRNA SNHG7/miR-181b-5p/TLR4 Activates Inflammation And Promotes Pyroptosis Through NF-κB Signaling in Diabetic Nephropathy
MiR-181b-5p plays a critical role in the pyroptosis and injury of kidney tubular cells in diabetic kidney disease (DKD). T...
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy
Tubulointerstitial fibrosis (TIF), a critical pathological hallmark in progressive chronic kidney disease (CKD), may be po...
The Evolution and Recurrence of Chronic Subdural Hematoma was Associated with Different Distribution of Macrophage M1/M2 Polarization
The Evolution and Recurrence of Chronic Subdural Hematoma was Associated with Different Distribution of Macrophage M1/M2 Polarization
The pathogenesis of chronic subdural hematoma (CSDH) has traditionally been associated with inflammation, but the efficacy...
High level expression of OSBPL11 is associated with atherosclerosis and Alzheimer's disease
High level expression of OSBPL11 is associated with atherosclerosis and Alzheimer's disease
With the global aging population, the incidence of aging-related diseases such as Alzheimer's disease (AD) and atheros...
The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis
The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis
Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of tooth-supporting tissues. ...
March6 Protects Against Acute Kidney Injury by Suppressing Renal Tubular Epithelial Cell Ferroptosis Through the Destabilization of P53 and ACSL4 Proteins
March6 Protects Against Acute Kidney Injury by Suppressing Renal Tubular Epithelial Cell Ferroptosis Through the Destabilization of P53 and ACSL4 Proteins
Acute kidney injury (AKI) progression involves significant contributions from renal tubular epithelial cell ferroptosis. M...
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway
Periodontitis is a long-lasting inflammatory condition that significantly affects people's quality of life. This resea...
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