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Nimodipine attenuates neuroinflammation and delayed apoptotic neuronal death induced by trimethyltin in the dentate gyrus of mice
Nimodipine attenuates neuroinflammation and delayed apoptotic neuronal death induced by trimethyltin in the dentate gyrus of mice
L-type voltage-gated calcium channels (L-VGCCs) are thought to be involved in epileptogenesis and acute excitotoxicity. Ho...
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
Corosolic acid (CA) is a well-known natural pentacyclic triterpene found in numerous therapeutic plants that can exhibit m...
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Adriamycin is a cytotoxic anthracycline antibiotic used to treat a wide variety of cancers. This study was made to detect ...
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
We analyzed the toxic effect of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in the...
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
The aim of this study was to explore the mechanism of bone marrow stem cells (BMSCs) sheets constructed with different dos...
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Wounds are the common fates in various microbial infections and physical damages including accidents, surgery, and burns. ...
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Insufficient evidence regarding how maternal undernutrition affects craniofacial bone development persists. With its uniqu...
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
SARS-CoV-2 infection is considered as a multi-organ disease, and several studies highlighted the relevance of the virus in...
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Immune checkpoint blockade therapy has demonstrated significant therapeutic effects in certain types of cancers. However, ...
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths and the fifth most common cancer worldw...
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
This study tested the hypothesis that empagliflozin (EMPA) therapy effectively protected renal and heart functions via dow...
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
There is an increased prevalence of cancer, and chemotherapy is widely and routinely utilized to manage the majority of ca...
The role and mechanism of β-catenin-mediated skeletal muscle satellite cells in osteoporotic fractures by Jian-Pi-Bu-Shen formula
The role and mechanism of β-catenin-mediated skeletal muscle satellite cells in osteoporotic fractures by Jian-Pi-Bu-Shen formula
Osteoporosis is a metabolic bone disease. β-Catenin is associated with fractures. Jian-Pi-Bu-Shen (JPBS) can promote ...
Serum biochemical evaluation following administration of imidazolyl thiazolidinedione in streptozotocin-induced diabetic rats
Serum biochemical evaluation following administration of imidazolyl thiazolidinedione in streptozotocin-induced diabetic rats
Diabetes mellitus represents a prominent global health concern, characterized by a rising prevalence rate. Type 2 Diabetes...
Type I Diabetes Mellitus impairs cytotoxic immunity through CEACAM5 upregulation in colorectal cancer
Type I Diabetes Mellitus impairs cytotoxic immunity through CEACAM5 upregulation in colorectal cancer
Type 1 diabetes (T1D) is characterized by an autoimmune-mediated destruction of pancreatic beta cells and a chronic inflam...
CLDN11 deficiency upregulates FOXM1 to facilitate breast tumor progression through hedgehog signaling pathway
CLDN11 deficiency upregulates FOXM1 to facilitate breast tumor progression through hedgehog signaling pathway
Claudins (CLDNs) play a crucial role in regulating the permeability of epithelial barriers and can impact tumor behavior t...
Chronic unpredictable mild stress increases serum aldosterone without affecting corticosterone levels and induces hepatic steatosis and renal injury in young adult male rats
Chronic unpredictable mild stress increases serum aldosterone without affecting corticosterone levels and induces hepatic steatosis and renal injury in young adult male rats
Stress is often associated with anxiety and depressive symptoms in adolescents. Stress is associated with components of me...
An overview on liposarcoma subtypes: Genetic alterations and recent advances in therapeutic strategies
An overview on liposarcoma subtypes: Genetic alterations and recent advances in therapeutic strategies
Liposarcoma (LPS) is a rare malignancy of adipocytic differentiation. According to World Health Organization classificatio...
Subcellular expression of MTA1, HIF1A and p53 in primary tumor predicts aggressive triple negative breast cancers: a meta-analysis based study
Subcellular expression of MTA1, HIF1A and p53 in primary tumor predicts aggressive triple negative breast cancers: a meta-analysis based study
The prevalence of TNBC in India is higher compared to western countries. There is a multitude of biomarkers associated wit...
Effect of Oxygen–Glucose Deprivation of Microglia-Derived Exosomes on Hippocampal Neurons: A Study on miR-124 and Inflammatory Cytokines
Effect of Oxygen–Glucose Deprivation of Microglia-Derived Exosomes on Hippocampal Neurons: A Study on miR-124 and Inflammatory Cytokines
Stroke is a cerebrovascular disease that threatens human health. Developing safe and effective drugs and finding therapeut...
Zinc-alkaline phosphatase at sites of aortic calcification
Zinc-alkaline phosphatase at sites of aortic calcification
Zinc (Zn) is a normal trace element in mineralizing tissues, but it is unclear whether it is primarily bound to the minera...
Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure
Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure
Obesity is defined by increased adipose tissue volume and has become a major risk factor for reproduction. Recent studies ...
STAT1 aggravates kidney injury by NOD-like receptor (NLRP3) signaling in MRL-lpr mice
STAT1 aggravates kidney injury by NOD-like receptor (NLRP3) signaling in MRL-lpr mice
Systemic lupus erythematosus (SLE) is a persistent autoimmune disorder that can culminate in lupus nephritis (LN), an intr...
SPP-5 affects larval arrest via insulin signaling pathway in Caenorhabditis elegans
SPP-5 affects larval arrest via insulin signaling pathway in Caenorhabditis elegans
Diapause is an endocrine-mediated metabolic and growth arrest state in response to unfavorable external environments. The ...
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells
Background: Sorting nexin 14 (SNX14) is a member of the sorting junction protein family. Its specific roles in cancer deve...
Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway
Anshen Shumai Decoction inhibits post-infarction inflammation and myocardial remodeling through suppression of the p38 MAPK/c-FOS/EGR1 pathway
Anshen Shumai Decoction (ASSMD) is traditionally employed to manage coronary artery disease arrhythmias. Its protective ef...
Ucf-101 alleviates Ischaemia/Reperfusion induced retinal inflammation and injury via suppressing oxidative damage
Ucf-101 alleviates Ischaemia/Reperfusion induced retinal inflammation and injury via suppressing oxidative damage
The Omi/HtrA2 inhibitor 5-[5-(2-nitrophenyl) furfuryliodine]-1,3-diphenyl-2-thiobarbituric acid (Ucf-101) has shown neurop...
Wood calamint ameliorates ethanol-induced stomach injury in rats by augmentation of hsp/bax and inflammatory mechanisms
Wood calamint ameliorates ethanol-induced stomach injury in rats by augmentation of hsp/bax and inflammatory mechanisms
Clinopodium menthifolium (wood calamint) is a folkloric medicinal plant ingested as a treatment for many human disorders i...
Protective effect of rubber seed oil on human endothelial cells
Protective effect of rubber seed oil on human endothelial cells
This study was conducted to characterize the antioxidant and anti-inflammatory properties of Rubber Seed Oil (RSO) against...
Interleukin-10 deficiency induces thoracic perivascular adipose tissue whitening and vascular remodeling
Interleukin-10 deficiency induces thoracic perivascular adipose tissue whitening and vascular remodeling
Absence of endogenous IL-10 reduces total thoracic PVAT. Brown adipose PVAT whitening is observed in thoracic aortas from ...
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