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Forsythoside A inhibited inflammatory response by inhibiting p38 JNK/MAPK/ERK and NF-κB signaling in pneumonia
Forsythoside A inhibited inflammatory response by inhibiting p38 JNK/MAPK/ERK and NF-κB signaling in pneumonia
S. aureus pneumonia, one of the most common S. aureus-induced diseases, is characterized by infectious inflammation in alv...
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting
Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with poor prognosis due to late detection, rapid pro...
STAT3/FoxO3a/Sirt1 pathway inhibition by ginsenoside Rc ameliorates cardiomyocyte damage in septic cardiomyopathy by altering macrophage polarization
STAT3/FoxO3a/Sirt1 pathway inhibition by ginsenoside Rc ameliorates cardiomyocyte damage in septic cardiomyopathy by altering macrophage polarization
This study explored the role and mechanism of action of ginsenoside Rc in treating septic cardiomyopathy. Ginsenoside Rc m...
Ameliorative effects of chitosan on fluoride-induced kidney injury in rats: a stereological and immunohistochemical study
Ameliorative effects of chitosan on fluoride-induced kidney injury in rats: a stereological and immunohistochemical study
The present study aimed to investigate the possible protective effects of chitosan (CS) on fluoride-induced nephrotoxicity...
Protective effects of lupeol on pesticides induced testicular and oxidative damage of male rats
Protective effects of lupeol on pesticides induced testicular and oxidative damage of male rats
Pesticides are used as insecticides in agriculture. Lupeol (LUP) is a dietary triterpene with antioxidant effects. This ex...
Demethylated miR-184 regulates EPB41L5 and downregulates Notch signaling to inhibit metastasis in colorectal cancer
Demethylated miR-184 regulates EPB41L5 and downregulates Notch signaling to inhibit metastasis in colorectal cancer
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with metastasis being a major contr...
Oleuropein attenuates cardiac and lung injury induced by 5-fluorouracil via modulating oxidative stress and TNF-α/IL-6 signaling pathway
Oleuropein attenuates cardiac and lung injury induced by 5-fluorouracil via modulating oxidative stress and TNF-α/IL-6 signaling pathway
The cardiac and lung damage are considered a serious risk associated with the administration of chemotherapy agents like 5...
The effects of the GLP1 analog liraglutide on allodynia and motor coordination in peripheral neuropathy induced by a chemotherapeutic agent, cisplatin
The effects of the GLP1 analog liraglutide on allodynia and motor coordination in peripheral neuropathy induced by a chemotherapeutic agent, cisplatin
Peripheral neuropathy is one of the dose-limiting side effects of cisplatin (CIS) and still has no effective treatment. In...
Downregulation of MPC1 promotes HCC cell proliferation and metastasis via the STAT3 pathway
Downregulation of MPC1 promotes HCC cell proliferation and metastasis via the STAT3 pathway
Hepatocellular carcinoma (HCC) is prevalent globally, and the discovery of new targets is vital for the treatment of HCC. ...
Activation of Hippo/YAP signaling pathway exacerbates vascular remodeling and aggravates hypertension by upregulating Foxm1
Activation of Hippo/YAP signaling pathway exacerbates vascular remodeling and aggravates hypertension by upregulating Foxm1
The Hippo/YAP signaling pathway is closely related to the occurrence and development of cardiovascular diseases. However, ...
Evaluation of the protective effects of raw and roasted pumpkin ( L.) seed-supplemented diets on cisplatin-induced cardiotoxicity in rats
Evaluation of the protective effects of raw and roasted pumpkin ( L.) seed-supplemented diets on cisplatin-induced cardiotoxicity in rats
Cardiovascular diseases are among the top killer diseases globally. This work assessed the cardioprotective ability of raw...
Effect of autologous cytokine-rich serum and platelet-rich plasma administration on oxidative status, minerals and proinflammatory cytokines in brain and serum in cyclophosphamide-induced ovarian failure
Effect of autologous cytokine-rich serum and platelet-rich plasma administration on oxidative status, minerals and proinflammatory cytokines in brain and serum in cyclophosphamide-induced ovarian failure
Cyclophosphamide (CP) is one of the most commonly used chemotherapy agents and carries a high risk of ovarian damage. This...
A diet-driven metabolic dysfunction-associated steatohepatitis (MASH) mouse model resembles the corresponding human disease
A diet-driven metabolic dysfunction-associated steatohepatitis (MASH) mouse model resembles the corresponding human disease
Most of the available preclinical Metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MA...
Exploring neuro-glial interaction mechanisms in myelin plasticity for learning and memory enhancement
Exploring neuro-glial interaction mechanisms in myelin plasticity for learning and memory enhancement
Neural plasticity was considered as the principal mechanism for learning and memory many decades ago. So our stud...
Dysregulated autophagy in periodontal ligament stem cells of individuals with type 2 diabetes mellitus and periodontitis
Dysregulated autophagy in periodontal ligament stem cells of individuals with type 2 diabetes mellitus and periodontitis
This study aimed to investigate autophagy and its associated mechanisms in periodontal ligament stem cells (PDLSCs) within...
Arsenic-induced neurocardiac toxicity and protective role of Resveratrol: histopathological and molecular insights
Arsenic-induced neurocardiac toxicity and protective role of Resveratrol: histopathological and molecular insights
Arsenic toxicity is a global health problem chiefly targeting soft tissues of the body like the brain and heart. The major...
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery
Scars are traces of tissue loss left behind by connective tissue overgrowth and repair. Studies in recent years have shown...
Myoinositol improves sperm parameters in diabetic rats by reducing oxidative stress and regulating apoptosis-related genes
Myoinositol improves sperm parameters in diabetic rats by reducing oxidative stress and regulating apoptosis-related genes
Diabetes disrupts spermatogenesis and leads to low-quality sperm by causing oxidative stress, inducing apoptosis and reduc...
Nimodipine attenuates neuroinflammation and delayed apoptotic neuronal death induced by trimethyltin in the dentate gyrus of mice
Nimodipine attenuates neuroinflammation and delayed apoptotic neuronal death induced by trimethyltin in the dentate gyrus of mice
L-type voltage-gated calcium channels (L-VGCCs) are thought to be involved in epileptogenesis and acute excitotoxicity. Ho...
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
A triterpenoid (corosolic acid) ameliorated AOM-mediated aberrant crypt foci in rats: modulation of Bax/PCNA, antioxidant and inflammatory mechanisms
Corosolic acid (CA) is a well-known natural pentacyclic triterpene found in numerous therapeutic plants that can exhibit m...
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Cytoprotective effect of garlic alone versus co-administration of garlic and resveratrol in adriamycin-induced lung toxicity in albino rat: light microscopic, ultrastructural and immunohistochemical study
Adriamycin is a cytotoxic anthracycline antibiotic used to treat a wide variety of cancers. This study was made to detect ...
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
Harmony in nature's elixir: a comprehensive exploration of ethanol and nano-formulated extracts from Passiflora incarnata leaves: unveiling in vitro cytotoxicity, acute and sub-acute toxicity profiles in Swiss albino mice
We analyzed the toxic effect of the ethanolic extract of Passiflora incarnata (EEP) and its nanoformulation (N-EEP) in the...
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
Exploration of N6-methyladenosine modification in ascorbic acid 2-glucoside constructed stem cell sheets
The aim of this study was to explore the mechanism of bone marrow stem cells (BMSCs) sheets constructed with different dos...
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Revealing the molecular mechanisms in wound healing and the effects of different physiological factors including diabetes, age, and stress
Wounds are the common fates in various microbial infections and physical damages including accidents, surgery, and burns. ...
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Mandible development under gestational protein restriction: cellular and molecular mechanisms
Insufficient evidence regarding how maternal undernutrition affects craniofacial bone development persists. With its uniqu...
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
Effects of SARS-COV-2 on molecules involved in vascularization and autophagy in placenta tissues
SARS-CoV-2 infection is considered as a multi-organ disease, and several studies highlighted the relevance of the virus in...
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Physical activity enhances the effect of immune checkpoint blockade by inhibiting the intratumoral HIF1-α/CEACM1 axis
Immune checkpoint blockade therapy has demonstrated significant therapeutic effects in certain types of cancers. However, ...
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Ameliorative effects of Turbinaria ornata extract on hepatocellular carcinoma induced by diethylnitrosamine in-vivo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths and the fifth most common cancer worldw...
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
SGLT2 inhibitor downregulated oxidative stress via activating AMPK pathway for cardiorenal (CR) protection in CR syndrome rodent fed with high protein diet
This study tested the hypothesis that empagliflozin (EMPA) therapy effectively protected renal and heart functions via dow...
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example
There is an increased prevalence of cancer, and chemotherapy is widely and routinely utilized to manage the majority of ca...
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