Abdolsamadi M, Mohammadi F, Nashtaei MS, Teimouri M, Sardar R, Dayani M, Zandieh Z (2020) Does myoinositol supplement improve sperm parameters and DNA integrity in patients with oligoasthenoteratozoospermia after the freezing–thawing process? Cell Tissue Banking 21:99–106

Article  PubMed  Google Scholar 

Aguirre-Arias MV, Velarde V, Moreno RD (2017) Effects of ascorbic acid on spermatogenesis and sperm parameters in diabetic rats. Cell Tissue Res 370:305–317

Article  CAS  PubMed  Google Scholar 

Alshehri MA, Ali Seyed M, Alasmari A, Panneerselvam C, Hajad Alboqami H, Ahmed Alkeridis L, Aioub AA (2024) Retama raetam extract for testicular health in type 2 diabetic rats: insight view on the steroidogenesis, antioxidants, and molecular docking scores of bioactive compounds against bax. J Food Biochem 2024(1):7945589

Google Scholar 

Andlib N, Sajad M, Kumar R, Thakur SC (2023) Abnormalities in sex hormones and sexual dysfunction in males with diabetes mellitus: a mechanistic insight. Acta Histochem 125(1):151974

Article  CAS  PubMed  Google Scholar 

Artini PG, Casarosa E, Carletti E, Monteleone P, Di Noia A, Di Berardino O (2017) In vitro effect of myo-inositol on sperm motility in normal and oligoasthenospermia patients undergoing in vitro fertilization. Gynecol Endocrinol 33(2):109–112

Article  CAS  PubMed  Google Scholar 

Asimakopoulos G, Pergialiotis V, Anastasiou E, Antsaklis P, Theodora M, Vogiatzi E, Daskalakis G (2020) Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: study protocol for a randomized controlled trial. Trials 21:1–10

Article  Google Scholar 

Avram VF, Merce AP, Hâncu IM, Bătrân AD, Kennedy G, Rosca MG, Muntean DM (2022) Impairment of mitochondrial respiration in metabolic diseases: an overview. Int J Mol Sci 23(16):8852

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bahmanzadeh M, Goodarzi MT, Rezaei Farimani A, Fathi N, Alizadeh Z (2019) Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin–nicotinamide-induced type 2 diabetic rats. Andrologia 51(8):e13313

Article  PubMed  Google Scholar 

Bell EL, Nagamori I, Williams EO, Del Rosario AM, Bryson BD, Watson N, Guarente L (2014) SirT1 is required in the male germ cell for differentiation and fecundity in mice. Development 141(18):3495–3504

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benvenga S, Micali A, Pallio G, Vita R, Malta C, Puzzolo D, Minutoli L (2019) Effects of myo-inositol alone and in combination with seleno-lmethionine on cadmium-induced testicular damage in mice. Curr Mol Pharmacol 12(4):311–323. https://doi.org/10.2174/1874467212666190620143303

Article  CAS  PubMed  Google Scholar 

Benvenga S, Nordio M, Laganà AS, Unfer V (2021) The role of inositol in thyroid physiology and in subclinical hypothyroidism management. Front Endocrinol 12:662582

Article  Google Scholar 

Bezerra LG, Silva AM, Jurema AP, Dantas MR, Pereira AG, Oliveira MF, Silva AR (2023) Changes in sperm morphology, morphometry, and motility from the epididymis to the vas deferens in rheas (Rhea americana Linnaeus,1758). Animals 13(9):1483

Article  PubMed  PubMed Central  Google Scholar 

Bhutia Y, Ghosh A, Sherpa ML, Pal R, Mohanta PK (2011) Serum malondialdehyde level: surrogate stress marker in the Sikkimese diabetics. J Nat Sci Biol Med 2(1):107–112. https://doi.org/10.4103/0976-9668.82309

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cabrera-Cruz H, Oróstica L, Plaza-Parrochia F, Torres-Pinto I, Romero C, Vega M (2020) The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Am J Physiol Endocrinol Metab 318(2):E237-e248. https://doi.org/10.1152/ajpendo.00162.2019

Article  CAS  PubMed  Google Scholar 

Calogero AE, Gullo G, La Vignera S, Condorelli RA, Vaiarelli A (2015) Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study. Andrology 3(3):491–495. https://doi.org/10.1111/andr.12025

Article  CAS  PubMed  Google Scholar 

Cellat M, İşler CT, Uyar A, Kuzu M, Aydın T, Etyemez M, Güvenç M (2022) Protective effect of Smilax excelsa L. pretreatment via antioxidant anti-inflammatory effects and activation of Nrf-2/HO-1 pathway in testicular torsion model. J Food Biochem 46(8):e14161

Article  CAS  PubMed  Google Scholar 

Condorelli RA, La Vignera S, Di Bari F, Unfer V, Calogero AE (2011) Effects of myoinositol on sperm mitochondrial function in-vitro. Eur Rev Med Pharmacol Sci 15(2):129–134

CAS  PubMed  Google Scholar 

Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Kroemer G (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14(5):1029–1039. https://doi.org/10.1038/sj.cdd.4402099

Article  CAS  PubMed  Google Scholar 

Croze ML, Géloën A, Soulage CO (2015) Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementation. Br J Nutr 113(12):1862–1875. https://doi.org/10.1017/s000711451500121x

Article  CAS  PubMed  Google Scholar 

DiNicolantonio, J. J., & O'Keefe, J. H. (2022). Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes (Vol. 9, pp. e001989): Archives of Disease in childhood.

Dutta D, Park I, Mills NC (2012) Fixation temperature affects DNA integrity in the testis as measured by the TUNEL assay. Toxicol Pathol 40(4):667–674

Article  CAS  PubMed  Google Scholar 

Ebokaiwe AP, Ijomone OM, Osawe SO, Chukwu CJ, Ejike CE, Zhang G, Wang F (2018) Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus. Redox Rep 23(1):194–205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ekwall H, Jansson Å, Sjöberg P, Plöen L (1984) Differentiation of the rat testis between 20 and 120 days of age. Arch Androl 13(1):27–36

Article  CAS  PubMed  Google Scholar 

Freitas MJ, Vijayaraghavan S, Fardilha M (2017) Signaling mechanisms in mammalian sperm motility. Biol Reprod 96(1):2–12

PubMed  Google Scholar 

Gonzalez-Uarquin F, Rodehutscord M, Huber K (2020) Myo-inositol: its metabolism and potential implications for poultry nutrition-a review. Poult Sci 99(2):893–905. https://doi.org/10.1016/j.psj.2019.10.014

Article  CAS  PubMed  Google Scholar 

Han X-X, Jiang Y-P, Liu N, Wu J, Yang J-M, Li Y-X, Yu J-Q (2019) Protective effects of astragalin on spermatogenesis in streptozotocin-induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation. Biomed Pharmacother 110:561–570

Article  CAS  PubMed  Google Scholar 

Hwang JY (2024) Analysis of Ca(2+)-mediated sperm motility to evaluate the functional normality of the sperm-specific Ca(2+) channel. CatSper Front Cell Dev Biol 12:1284988. https://doi.org/10.3389/fcell.2024.1284988

Article  PubMed  Google Scholar 

Jawad A, Oh D, Choi H, Kim M, Cai L, Lee J, Hyun S-H (2023) Myo-inositol improves the viability of boar sperm during liquid storage. Front Veterinary Sci 10:1150984

Article  Google Scholar 

Jin Z, Cao Y, Wen Q, Zhang H, Fang Z, Zhao Q, Zhang Z (2024) Dapagliflozin ameliorates diabetes-induced spermatogenic dysfunction by modulating the adenosine metabolism along the gut microbiota-testis axis. Sci Rep 14(1):641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson A, Cheng S-C, Tsou D, Kong Z-L (2019) Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract. Biomed Pharmacother 112:108684

Article  CAS  PubMed  Google Scholar 

Katalinic V, Modun D, Music I, Boban M (2005) Gender differences in antioxidant capacity of rat tissues determined by 2, 2′-azinobis (3-ethylbenzothiazoline 6-sulfonate; ABTS) and ferric reducing antioxidant power (FRAP) assays. Comp Biochem Physiol C: Toxicol Pharmacol 140(1):47–52

CAS  PubMed  Google Scholar 

Kiani M, Mehranjani MS, Shariatzadeh MA (2024) Empagliflozin reduces the adverse effects of diabetes mellitus on testicular tissue in type 2 diabetic Rats: A stereological and biochemical study. Biochem Pharmacol 223:116135