Oleuropein attenuates cardiac and lung injury induced by 5-fluorouracil via modulating oxidative stress and TNF-α/IL-6 signaling pathway

Andreadou I, Sigala F, Iliodromitis EK, Papaefthimiou M, Sigalas C, Aligiannis N, Savvari P, Gorgoulis V, Papalabros E, Kremastinos DT (2007) Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. J Mol Cell Cardiol 42(3):549–558

Article  CAS  PubMed  Google Scholar 

Barary M, Hosseinzadeh R, Kazemi S, Liang JJ, Mansoori R, Sio TT, Hosseini M, Moghadamnia AA (2022) The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats. Sci Rep 12(1):8661

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barchowsky A, Frleta D, Vincenti MP (2000) Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. Cytokine 12(10):1469–1479

Article  CAS  PubMed  Google Scholar 

Boss A, Bishop KS, Marlow G, Barnett MP, Ferguson LR (2016) Evidence to support the anti-cancer effect of olive leaf extract and future directions. Nutrients 8(8):513

Article  PubMed  PubMed Central  Google Scholar 

Canale ML, Camerini A, Stroppa S, Porta RP, Caravelli P, Mariani M, Balbarini A, Ricci S (2006) A case of acute myocardial infarction during 5-fluorouracil infusion. J Cardiovasc Med (Hagerstown) 7(11):835–837

Article  PubMed  Google Scholar 

Castejón ML, Rosillo M, Montoya T, González-Benjumea A, Fernández-Bolaños JG, Alarcón-de-la-Lastra C (2017) Oleuropein down-regulated IL-1β-induced inflammation and oxidative stress in human synovial fibroblast cell line SW982. Food Funct 8(5):1890–1898

Article  PubMed  Google Scholar 

Chan AK, Choo BA, Glaholm J (2011) Pulmonary toxicity with oxaliplatin and capecitabine/5-fluorouracil chemotherapy: a case report and review of the literature. Onkologie 34(8–9):443–446

Article  PubMed  Google Scholar 

De Forni M, Malet-Martino MC, Jaillais P, Shubinski RE, Bachaud JM, Lemaire L, Canal P, Chevreau C, Carrié D, Soulié P et al (1992) Cardiotoxicity of high-dose continuous infusion fluorouracil: a prospective clinical study. J Clin Oncol 10(11):1795–1801

Article  PubMed  Google Scholar 

Diba M, Seghatoleslam A, Namavari M, Assadi S, Vakili SN, Babaei Z, Akmali M (2021) Potential protective role of cyrtopodion scabrum in antioxidant parameters in serum and liver of rats with 5-fu-induced oxidative damage. Arch Razi Inst 76(1):95–105

CAS  PubMed  PubMed Central  Google Scholar 

Dikmen N, Cellat M, Etyemez M, İşler CT, Uyar A, Aydın T, Güvenç M (2021) Ameliorative effects of oleuropein on lipopolysaccharide-induced acute lung injury model in rats. Inflammation 44(6):2246–2259

Article  CAS  PubMed  Google Scholar 

Dyhl-Polk A, Schou M, Vistisen KK, Sillesen AS, Serup-Hansen E, Faber J, Klausen TW, Bojesen SE, Vaage-Nilsen M, Nielsen DL (2021) Myocardial ischemia induced by 5-fluorouracil: a prospective electrocardiographic and cardiac biomarker study. Oncologist 26(3):e403–e413

Article  CAS  PubMed  Google Scholar 

Geyikoglu F, Emir M, Colak S, Koc K, Turkez H, Bakir M, Hosseinigouzdagani M, Cerig S, Keles ON, Ozek NS (2017a) Effect of oleuropein against chemotherapy drug-induced histological changes, oxidative stress, and DNA damages in rat kidney injury. J Food Drug Anal 25(2):447–459

Article  CAS  PubMed  Google Scholar 

Geyikoglu F, Isikgoz H, Onalan H, Colak S, Cerig S, Bakir M, Hosseinigouzdagani M, Koc K, Erol HS, Saglam YS, Yildirim S (2017b) Impact of high-dose oleuropein on cisplatin-induced oxidative stress, genotoxicity and pathological changes in rat stomach and lung. J Asian Nat Prod Res 19(12):1214–1231

Article  CAS  PubMed  Google Scholar 

Golmohammadi MG, Banaei S, Timar M, Abedi A (2023) Saponin protects against cyclophosphamide-induced kidney and liver damage via antioxidant and anti-inflammatory actions. Physiol Int 110(2):108–120

Article  CAS  PubMed  Google Scholar 

González P, Lozano P, Ros G, Solano F (2023) Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci 24(11):9352

Article  PubMed  PubMed Central  Google Scholar 

Gorzynik-Debicka M, Przychodzen P, Cappello F, Kuban-Jankowska A, Marino Gammazza A, Knap N, Wozniak M, Gorska-Ponikowska M (2018) Potential health benefits of olive oil and plant polyphenols. Int J Mol Sci 19(3):686

Article  PubMed  PubMed Central  Google Scholar 

Gowda S, Desai PB, Hull VV, Avinash AK, Vernekar SN, Kulkarni SS (2009) A review on laboratory liver function tests. Pan Afr Med J 3:17

PubMed  PubMed Central  Google Scholar 

Huang S, Lin Y, Liang Z, Wu Z, Chen Y, Chen C (2019) Erythropoietin helix B surface peptide modulates miR-21/Atg12 axis to alleviates cardiomyocyte hypoxia-reoxygenation injury. Am J Transl Res 11(4):2422–2430

CAS  PubMed  PubMed Central  Google Scholar 

Idriss HT, Naismith JH (2000) TNFα and the TNF receptor superfamily: structure-function relationship (s). Microsc Res Tech 50(3):184–195

Article  CAS  PubMed  Google Scholar 

Janahmadi Z, Nekooeian AA, Moaref AR, Emamghoreishi M (2017) Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects. Naunyn Schmiedebergs Arch Pharmacol 390(3):245–252

Article  CAS  PubMed  Google Scholar 

Khalatbary AR, Zarrinjoei GR (2012) Anti-inflammatory effect of oleuropein in experimental rat spinal cord trauma. Iran Red Crescent Med J 14(4):229–234

CAS  PubMed  PubMed Central  Google Scholar 

Lee W, Song G, Bae H (2022) Matairesinol induces mitochondrial dysfunction and exerts synergistic anticancer effects with 5-fluorouracil in pancreatic cancer cells. Mar Drugs 20(8):473

Article  CAS  PubMed  PubMed Central  Google Scholar 

Longley DB, Harkin DP, Johnston PG (2003) 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 3(5):330–338

Article  CAS  PubMed  Google Scholar 

Menezes RCR, Peres KK, Costa-Valle MT, Faccioli LS, Dallegrave E, Garavaglia J, Dal Bosco SM (2022) Oral administration of oleuropein and olive leaf extract has cardioprotective effects in rodents: a systematic review. Rev Port Cardiol 41(2):167–175

Article  PubMed  Google Scholar 

Mishra T, Shokr M, Ahmed A, Afonso L (2019) Acute reversible left ventricular systolic dysfunction associated with 5-fluorouracil therapy: a rare and increasingly recognised cardiotoxicity of a commonly used drug. BMJ Case Rep 12(9):e230499

Article  PubMed  PubMed Central  Google Scholar 

Nasrallah H, Aissa I, Slim C, Boujbiha MA, Zaouali MA, Bejaoui M, Wilke V, Ben Jannet H, Mosbah H, Ben Abdennebi H (2020) Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney. Life Sci 255:117833

Article  CAS  PubMed  Google Scholar 

Omar SH (2010) Oleuropein in olive and its pharmacological effects. Sci Pharm 78(2):133–154

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozawa Y, Akahori D, Koda K, Abe T, Hasegawa H, Matsui T, Tanahashi M, Niwa H, Yamada K, Yokomura K, Suda T (2016) Distinctive impact of pre-existing interstitial lung disease on the risk of chemotherapy-related lung injury in patients with lung cancer. Cancer Chemother Pharmacol 77(5):1031–1038

Article  CAS  PubMed  Google Scholar 

Pojero F, Aiello A, Gervasi F, Caruso C, Ligotti ME, Calabrò A, Procopio A, Candore G, Accardi G, Allegra M (2022) Effects of oleuropein and hydroxytyrosol on inflammatory mediators: consequences on inflammaging. Int J Mol Sci 24(1):380

Article  PubMed  PubMed Central  Google Scholar 

Qabaha K, Al-Rimawi F, Qasem A, Naser SA (2018) Oleuropein is responsible for the major anti-inflammatory effects of olive leaf extract. J Med Food 21(3):302–305

Article  CAS  PubMed 

Comments (0)

No login
gif