STAT3/FoxO3a/Sirt1 pathway inhibition by ginsenoside Rc ameliorates cardiomyocyte damage in septic cardiomyopathy by altering macrophage polarization

Chen DD, Wang HW, Cai XJ (2021a) Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1. Innate Immun 27(5):377–387

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X et al (2021b) The roles of macrophage polarization in the host immune response to sepsis. Int Immunopharmacol 96:107791

Article  CAS  PubMed  Google Scholar 

Cheng Y et al (2018) N-Propargyl caffeamide skews macrophages towards a resolving M2-Like phenotype against myocardial ischemic injury via activating Nrf2/HO-1 pathway and inhibiting NF-kB pathway. Cell Physiol Biochem 47(6):2544–2557

Article  CAS  PubMed  Google Scholar 

Cimolai MC et al (2015) Mitochondrial mechanisms in septic cardiomyopathy. Int J Mol Sci 16(8):17763–17778

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Onofrio N, Servillo L, Balestrieri ML (2018) SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection. Antioxid Redox Signal 28(8):711–732

Article  PubMed  PubMed Central  Google Scholar 

Fang X, Wang J (2018) [Role of mitochondrial dysfunction in the pathogenesis of septic cardiomyopathy]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 30(2):189–192

PubMed  Google Scholar 

Haghikia A et al (2014) STAT3, a key regulator of cell-to-cell communication in the heart. Cardiovasc Res 102(2):281–289

Article  CAS  PubMed  Google Scholar 

Han D et al (2017) Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist. Free Radic Biol Med 113:291–303

Article  CAS  PubMed  Google Scholar 

Huang Q et al (2021) A SIRT1 activator, ginsenoside Rc, promotes energy metabolism in cardiomyocytes and neurons. J Am Chem Soc 143(3):1416–1427

Article  CAS  PubMed  Google Scholar 

Jiang T et al (2021a) IL-6/STAT3 signaling promotes cardiac dysfunction by upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic reticulum membranes formation in sepsis mice. Front Cardiovasc Med 8:790612

Article  CAS  PubMed  Google Scholar 

Jiang X et al (2021b) Irisin attenuates oxidative stress, mitochondrial dysfunction, and apoptosis in the H9C2 cellular model of septic cardiomyopathy through augmenting Fundc1-Dependent mitophagy. Oxid Med Cell Longev 2021:p2989974

Article  Google Scholar 

Kakihana Y et al (2016) Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care 4:22

Article  PubMed  PubMed Central  Google Scholar 

Kim DH et al (2014) Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. Arch Pharm Res 37(6):813–820

Article  CAS  PubMed  Google Scholar 

Li Z et al (2019) GSK-3beta Inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity. J Cell Mol Med 23(11):7796–7809

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z et al (2020) miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cell Signal 74:109716

Article  CAS  PubMed  Google Scholar 

Li Z et al (2021) Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Prolif 54(2):e12962

Article  CAS  PubMed  Google Scholar 

Liu YC et al (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10(5):520–529

Article  PubMed  PubMed Central  Google Scholar 

Liu L et al (2021) Adiponectin attenuates Lipopolysaccharide-induced apoptosis by regulating the Cx43/PI3K/AKT pathway. Front Pharmacol 12:644225

Article  CAS  PubMed  PubMed Central  Google Scholar 

Long X et al (2021) Upregulation of miR–335 exerts protective effects against sepsis–induced myocardial injury. Mol Med Rep, 24(5)

Luo TT et al (2020) Network Pharmacology in research of Chinese medicine formula: methodology, application and prospective. Chin J Integr Med 26(1):72–80

Article  CAS  PubMed  Google Scholar 

Mancuso C, Santangelo R (2017) Panax ginseng and Panax quinquefolius: from Pharmacology to toxicology. Food Chem Toxicol 107(Pt A):362–372

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muhammad J et al (2018) Network pharmacology: exploring the resources and methodologies. Curr Top Med Chem 18(12):949–964

Article  CAS  PubMed  Google Scholar 

Nho RS, Hergert P (2014) FoxO3a and disease progression. World J Biol Chem 5(3):346–354

Article  PubMed  PubMed Central  Google Scholar 

Pan J et al (2021) microRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis. J Transl Med 19(1):386

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romero-Bermejo FJ et al (2011) Sepsis-induced cardiomyopathy. Curr Cardiol Rev 7(3):163–183

Article  PubMed  PubMed Central  Google Scholar 

Shi L et al (2022) Ginsenoside Rc attenuates myocardial ischaemic injury through antioxidative and anti-inflammatory effects. Pharm Biol 60(1):1038–1046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan Y et al (2019) Mitochondrial injury and targeted intervention in septic cardiomyopathy. Curr Pharm Des 25(18):2060–2070

Article  CAS  PubMed  Google Scholar 

Vincelj J (2015) [Septic cardiomyopathy]. Acta Med Croatica 69(3):177–182

CAS  PubMed  Google Scholar 

Wang W et al (2021a) The role of the cholinergic anti-inflammatory pathway in septic cardiomyopathy. Int Immunopharmacol 90:107160

Article  CAS  PubMed  Google Scholar 

Wang L et al (2021b) Lipocalin 10 as a new prognostic biomarker in Sepsis-Induced myocardial dysfunction and mortality: A pilot study. Mediators Inflamm 2021:p6616270

Article  Google Scholar 

Wang Y et al (2021c) Ginsenoside Rc ameliorates endothelial insulin resistance via upregulation of Angiotensin-Converting enzyme 2. Front Pharmacol 12:620524

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R et al (2022) Pathogenetic mechanisms of septic cardiomyopathy. J Cell Physiol 237(1):49–58

Article  CAS  PubMed  Google Scholar 

Xie B et al (2022) Ginsenoside Rc ameliorated atherosclerosis via regulating gut microbiota and fecal metabolites. Front Pharmacol 13:990476

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xue Y et al (2021) Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats. J Food Sci 86(7):3252–3264

Comments (0)

No login
gif