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Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
Critical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually ...
BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability
BUB1B monoallelic germline variants contribute to prostate cancer predisposition by triggering chromosomal instability
Prostate cancer (PrCa) is the most frequently diagnosed cancer in men. Variants in known moderate- to high-penetrance gene...
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections
Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as ...
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Variants of human DECTIN-1 rs16910526 are linked to differential reactive oxygen species production and susceptibility to tuberculosis
Dectin-1 is a transmembrane receptor that plays a pivotal role in recognising fungi and Mycobacterium tuberculosis (Mtb). ...
A matter of new life and cell death: programmed cell death in the mammalian ovary
A matter of new life and cell death: programmed cell death in the mammalian ovary
The mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproduc...
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
Improving CRISPR–Cas9 directed faithful transgene integration outcomes by reducing unwanted random DNA integration
The field of genome editing has been revolutionized by the development of an easily programmable editing tool, the CRISPR&...
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance an...
Significance of hepatitis B virus capsid dephosphorylation via polymerase
Significance of hepatitis B virus capsid dephosphorylation via polymerase
It is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral D...
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Correction: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently m...
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis...
Butterflies in the gut: the interplay between intestinal microbiota and stress
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk ...
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in dange...
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remain...
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological m...
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles exten...
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (S...
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (m...
Extracellular release in the quality control of the mammalian mitochondria
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mit...
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The ...
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class...
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matri...
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have ...
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer maligna...
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrat...
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus eryth...
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheu...
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative t...
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with m...
Harnessing cell reprogramming for cardiac biological pacing
Harnessing cell reprogramming for cardiac biological pacing
Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life...
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