Mukhopadhyay S, Plüddemann A, Gordon S. Macrophage pattern recognition receptors in immunity, homeostasis and self tolerance. Adv Exp Med Biol. 2009;653:1–14.
Article CAS PubMed PubMed Central Google Scholar
Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–20.
Article CAS PubMed Google Scholar
Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell. 2014;157(5):1013–22.
Article CAS PubMed Google Scholar
Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145(5):745–57.
Article CAS PubMed PubMed Central Google Scholar
Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol. 2016;16(7):407–20.
Article CAS PubMed Google Scholar
Proell M, Riedl SJ, Fritz JH, Rojas AM, Schwarzenbacher R. The nod-like receptor (NLR) family: a tale of similarities and differences. PLoS ONE. 2008;3(4): e2119.
Article PubMed PubMed Central Google Scholar
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369(6510):eaas8995.
Article CAS PubMed PubMed Central Google Scholar
Sharma BR, Kanneganti T-D. NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. 2021;22(5):550–9.
Article CAS PubMed PubMed Central Google Scholar
Qiang R, Li Y, Dai X, Wenliang L. NLRP3 inflammasome in digestive diseases: from mechanism to therapy. Front Immunol. 2022;13: 978190.
Article CAS PubMed PubMed Central Google Scholar
Kelley N, Jeltema D, Duan Y, He Y. The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci. 2020;20(13):3328.
Wang L, Negro R, Wu H. TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation. Curr Opin Immunol. 2020;62:131–5.
Article CAS PubMed PubMed Central Google Scholar
Devant P, Kagan JC. Molecular mechanisms of gasdermin D pore-forming activity. Nat Immunol. 2023;24(7):1064–75.
Article CAS PubMed Google Scholar
Xu J, Núñez G. The NLRP3 inflammasome: activation and regulation. Trends Biochem Sci. 2023;48(4):331–44.
Article CAS PubMed Google Scholar
Kayagaki N, Warming S, Lamkanfi M, Walle LV, Louie S, Dong J, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479(7371):117–21.
Article CAS PubMed Google Scholar
Gaidt MM, Ebert TS, Chauhan D, Schmidt T, Schmid-Burgk JL, Rapino F, et al. Human monocytes engage an alternative inflammasome pathway. Immunity. 2016;44(4):833–46.
Article CAS PubMed Google Scholar
Lissner D, Siegmund B. The multifaceted role of the inflammasome in inflammatory bowel diseases. Sci World J. 2011;11:1536–1147.
Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell. 1995;80(3):401–11.
Article CAS PubMed Google Scholar
Dupaul-Chicoine J, Yeretssian G, Doiron K, Bergstrom KSB, McIntire CR, LeBlanc PM, Meunier C, Turbide C, Gros P, Beauchemin N, et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity. 2010;32(3):367–78.
Article CAS PubMed Google Scholar
He K, Wan T, Wang D, Hu J, Zhou T, Tao W, et al. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell. 2023;186(14):3033-3048.e20.
Jung HJ, Kang J-H, Pak S, Lee K, Seong JK, Oh SH. Detrimental role of nerve injury-induced protein 1 in myeloid cells under intestinal inflammatory conditions. Int J Mol Sci. 2020;21(2):614.
Article CAS PubMed PubMed Central Google Scholar
Zhen Y, Zhang H. NLRP3 inflammasome and inflammatory bowel disease. Front Immunol. 2019;10:276.
Article CAS PubMed PubMed Central Google Scholar
Graham DB, Xavier RJ. Pathway paradigms revealed from the genetics of inflammatory bowel disease. Nature. 2020;578(7796):527–39.
Article CAS PubMed PubMed Central Google Scholar
Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117(3):514–21.
Article CAS PubMed PubMed Central Google Scholar
Villani A-C, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, et al. Common variants in the NLRP3 region contribute to Crohn’s disease susceptibility. Nat Genet. 2009;41(1):71–6.
Article CAS PubMed Google Scholar
Zhang H-X, Wang Z-T, Lu X-X, Wang Y-G, Zhong J, Liu J. NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn’s disease (CD), in Chinese Han population. Inflamm Res. 2014;63(12):979–85.
Article CAS PubMed Google Scholar
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012;491(7422):119–24.
Article CAS PubMed PubMed Central Google Scholar
Zhou T, Liu B, Huang M, Luo Z, Chen Z, Zhao J, et al. Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. J Allergy Clin Immunol. 2021;147(1):267–79.
Article CAS PubMed Google Scholar
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, et al. MCC950 closes the active conformation of NLRP3 to an inactive state. Nat Chem Biol. 2019;15(6):560–4.
Article PubMed PubMed Central Google Scholar
Mao L, Kitani A, Strober W, Fuss IJ. The role of NLRP3 and IL-1β in the pathogenesis of inflammatory bowel disease. Front Immunol. 2018;9:2566.
Article PubMed PubMed Central Google Scholar
Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, et al. Western diet triggers NLRP3-dependent innate immune reprogramming. Cell. 2018;172(1–2):162-175.e14.
Article CAS PubMed PubMed Central Google Scholar
Chen Q-L, Yin H-R, He Q-Y, Wang Y. Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease. Biomed Pharmacother. 2021;138: 111442.
Article CAS PubMed Google Scholar
Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21(3):263–9.
Article CAS PubMed PubMed Central Google Scholar
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013;38(6):1154–63.
Article CAS PubMed Google Scholar
Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun. 2015;6:6734.
Article CAS PubMed Google Scholar
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT-H, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12(5):408–15.
Article CAS PubMed PubMed Central Google Scholar
Progatzky F, Sangha NJ, Yoshida N, McBrien M, Cheung J, Shia A, et al. Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nat Commun. 2015;5:5864.
Comments (0)