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Establishment and characterization of NCC-OS2-C1: a novel patient-derived cell line of osteosarcoma

Osteosarcoma is the most common primary bone sarcoma with a bimodal age distribution. Complete surgical resection with neo...

Human Cell

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Establishment and characterization of novel cancer cachexia-inducing cell line, Aku60GC, of scirrhous gastric cancer

Cancer cachexia is a pathological state characterized by severe weight loss, skeletal muscle depletion, and adipose tissue...

Human Cell

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LINC01559: roles, mechanisms, and clinical implications in human cancers

Long intergenic non-protein coding RNA 1559 (LINC01559), a long non-coding RNA (lncRNA) located on chromosome 12p13.1, pla...

Human Cell

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In vitro properties of four benign meningioma cells derived from WHO grade 1 meningiomas

Meningiomas are common intracranial tumors arising from the meninges. They exhibit heterogeneity in their biological behav...

Human Cell

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The influence of cell source on the senescence of human mesenchymal stem/stromal cells

While mesenchymal stem/stromal cells (MSCs) exhibit the ability to self-renew, they are not immortal; they eventually reac...

Human Cell

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Ovarian Leydig cells and neural crests

In our search for markers to identify and study ovarian Leydig cells, we utilized immunohistochemical techniques and visua...

Human Cell

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RFX5 promotes the progression of triple-negative breast cancer through transcriptional activation of JAG1

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by high recurrence rates, low su...

Human Cell

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SIX1 enhances aerobic glycolysis and progression in cervical cancer through ENO1

Cervical cancer is a significant threat to women's health, and its incidence in China has been increasing in recent ye...

Human Cell

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The role of MICAL2 in cancer progression: mechanisms, challenges, and therapeutic potential

Cancer is the greatest threat to public health worldwide and a major cause of human death. Compared with conventional chem...

Human Cell

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Clinical characteristics and induced pluripotent stem cells (iPSCs) disease model of Harel–Yoon syndrome caused by compound heterozygous ATAD3A variants

ATPase family AAA-domain-containing protein 3 A (ATAD3A) is enriched on the mitochondrial membrane and is essential ...

Human Cell

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LncRNA OLMALINC promotes osteosarcoma progression through USP1-mediated autophagy suppression

Osteosarcoma (OS) remains a challenging malignancy with poor prognosis, especially in metastatic or recurrent cases. Despi...

Human Cell

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Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Milk-derived exosomes (mEXOs) have critical roles in...

Human Cell

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Establishment and characterization of NCC-PS2-C1: a novel cell line of high-grade pleomorphic spindle cell sarcoma, most consistent with myxofibrosarcoma

Pleomorphic sarcoma (PS) is a heterogeneous group of malignant mesenchymal tumors that lack specific histological differen...

Human Cell

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Generation of human induced pluripotent stem cell lines derived from a patient carrying an intragenic deletion in the gene

Brain malformations with or without urinary tract defects (BRMUTD) are caused by heterozygous variants in the NFIA gene. B...

Human Cell

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Deficiency of synaptotagmin-1 aggravates pressure overload-induced cardiac hypertrophy and dysfunction via the p38 MAPK signaling pathway in mice

Cardiac hypertrophy is a major risk factor for heart failure and sudden cardiac death, but its molecular mechanisms have n...

Human Cell

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Establishment and characterization of Cri Du Chat neuronal stem cells: a novel promising resource to study the syndrome

The Cri Du Chat (CdC) Syndrome is a rare chromosome disease condition resulting from variable size deletion occurring on t...

Human Cell

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Advanced glycation end products alter the structural integrity, increase the permeability and transform the biocompatibility of collagen within the peritoneal membrane

In patients undergoing long-term peritoneal dialysis, the peritoneal accumulation of advanced glycation end-products (AGEs...

Human Cell

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Sunitinib-resistant renal cell carcinoma cell-derived exosomes promote facilitation of tumor progression via secretion of the lncRNA SNHG16

Renal cell carcinoma (RCC) is one of the most common tumors of high malignancy in the urological system. Sunitinib is comm...

Human Cell

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Assessment of non-myelotoxic agents as a preparatory regimen for hematopoietic stem cell gene therapy

RAG2 deficiency is characterized by a lack of B and T lymphocytes, causing severe lethal infections. Currently, RAG2 defic...

Human Cell

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MiR-124-3p inhibits cell stemness in glioblastoma via targeting EPHA2 through ALKBH5-mediated m6A modification

Glioblastoma (GBM) is the most aggressive form of glioma, characterized by high mortality and poor prognosis. Dysregulatio...

Human Cell

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Adiponectin-induced activation of ERK1/2 drives fibrosis in retinal pigment epithelial cells

Adiponectin (APN), a vasoactive cytokine produced by adipocytes, has emerged as a critical player in retinal diseases. Ren...

Human Cell

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Emodin regulated lactate metabolism by inhibiting MCT1 to delay non-small cell lung cancer progression

Lung cancer is one of the most common malignant tumors in the world, with high incidence rate and mortality. Monocarboxyla...

Human Cell

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Establishment and characterization of a patient-derived metastatic extraskeletal Ewing sarcoma cell line ES-ZSS-1

The methods available for treating metastatic Ewing sarcoma (ES) are inadequate; thus, innovative therapeutic approaches n...

Human Cell

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Establishment and characterization of NCC-SS6-C1: a novel patient-derived cell line of synovial sarcoma

Synovial sarcoma (SS) is identified as a sarcoma with monomorphic blue spindle cells that display variable epithelial diff...

Human Cell

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Cyclic tensile stress promotes osteogenic differentiation via upregulation of Piezo1 in human dental follicle stem cells

As periodontal progenitor cells, human dental follicle stem cells (hDFCs) play an important role in regenerative medicine ...

Human Cell

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GABAA receptor modulation by the endocannabinoid system: insights into the regulatory mechanisms involving glutamine synthetase and MAPK mediators

Baur R, Gertsch J, Sigel E. Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action ...

Human Cell

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Osteoarthritis rat serum-derived extracellular vesicles aggravate osteoarthritis development by inducing NLRP3-mediated pyroptotic cell death and cellular inflammation

Osteoarthritis (OA), degenerative joint disease, is the most prevalent form of arthritis worldwide. Besides its substantia...

Human Cell

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Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis

Oral bacteria naturally secrete extracellular vesicles (EVs), which have attracted attention for their promising biomedica...

Human Cell

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Sequencing-based study of neural induction of human dental pulp stem cells

Techniques for triggering neural differentiation of embryonic and induced pluripotent stem cells into neural stem cells an...

Human Cell

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Apelin-13 alleviates intrauterine adhesion by inhibiting epithelial–mesenchymal transition of endometrial epithelial cells and promoting angiogenesis

Intrauterine adhesion (IUA) is a common complication of surgical manipulation of the uterine cavity such as abortion. The ...

Human Cell

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