The role of MICAL2 in cancer progression: mechanisms, challenges, and therapeutic potential

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  PubMed  CAS  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. https://doi.org/10.3322/caac.21708.

Article  PubMed  Google Scholar 

Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol. 2018;15(2):81–94. https://doi.org/10.1038/nrclinonc.2017.166.

Article  PubMed  CAS  Google Scholar 

Hung R-J, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, et al. Mical links semaphorins to F-actin disassembly. Nature. 2010;463(7282):823–7. https://doi.org/10.1038/nature08724.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hung RJ, Pak CW, Terman JR. Direct redox regulation of F-actin assembly and disassembly by Mical. Science (New York, NY). 2011;334(6063):1710–3. https://doi.org/10.1126/science.1211956.

Article  CAS  Google Scholar 

Zhou W, Liu Y, Gao Y, Cheng Y, Chang R, Li X, et al. MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. Cancer Lett. 2020;483:75–86. https://doi.org/10.1016/j.canlet.2020.04.019.

Article  PubMed  CAS  Google Scholar 

Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, et al. MICAL, a novel CasL interacting molecule, associates with vimentin. J Biol Chem. 2002;277(17):14933–41. https://doi.org/10.1074/jbc.M111842200.

Article  PubMed  CAS  Google Scholar 

Frémont S, Romet-Lemonne G, Houdusse A, Echard A. Emerging roles of MICAL family proteins—from actin oxidation to membrane trafficking during cytokinesis. J Cell Sci. 2017;130(9):1509–17. https://doi.org/10.1242/jcs.202028.

Article  PubMed  CAS  Google Scholar 

Terman JR, Mao T, Pasterkamp RJ, Yu H-H, Kolodkin AL. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal. Cell. 2002;109(7):887–900. https://doi.org/10.1016/s0092-8674(02)00794-8.

Article  PubMed  CAS  Google Scholar 

Xue Y, Kuok C, Xiao A, Zhu Z, Lin S, Zhang B. Identification and expression analysis of mical family genes in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 2010;37(10):685–93. https://doi.org/10.1016/s1673-8527(09)60086-2.

Atkinson-Leadbeater K, Hehr CL, Johnston J, Bertolesi G, McFarlane S. EGCG stabilizes growth cone filopodia and impairs retinal ganglion cell axon guidance. Dev Dyn. 2016;245(6):667–77. https://doi.org/10.1002/dvdy.24406.

Article  PubMed  CAS  Google Scholar 

Rajan S, Terman JR, Reisler E. MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics. Front Cell Dev Biol. 2023;11:1124202. https://doi.org/10.3389/fcell.2023.1124202.

Article  PubMed  PubMed Central  Google Scholar 

Alto LT, Terman JR. MICALs. Curr Biol. 2018;28(9):R538–41. https://doi.org/10.1016/j.cub.2018.01.025.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Terman JR, Mao T, Pasterkamp RJ, Yu H-H, Kolodkin1 AL. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. Cell Biology. 2002;109(7):887–900. https://doi.org/10.1016/s0092-8674(02)00794-8.

Vanoni MA. Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. Arch Biochem Biophys. 2017;632:118–41. https://doi.org/10.1016/j.abb.2017.06.004.

Article  PubMed  CAS  Google Scholar 

Giridharan SS, Rohn JL, Naslavsky N, Caplan S. Differential regulation of actin microfilaments by human MICAL proteins. J Cell Sci. 2012;125(Pt 3):614–24. https://doi.org/10.1242/jcs.089367.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rouyère C, Serrano T, Frémont S, Echard A. Oxidation and reduction of actin: Origin, impact in vitro and functional consequences in vivo. Eur J Cell Biol. 2022;101(3): 151249. https://doi.org/10.1016/j.ejcb.2022.151249.

Article  PubMed  CAS  Google Scholar 

Ashida S, Furihata M, Katagiri T, Tamura K, Anazawa Y, Yoshioka H, et al. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. Clin Cancer Res. 2006;12(9):2767–73. https://doi.org/10.1158/1078-0432.Ccr-05-1995.

Article  PubMed  CAS  Google Scholar 

Lundquist MR, Storaska AJ, Liu TC, Larsen SD, Evans T, Neubig RR, et al. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. Cell. 2014;156(3):563–76. https://doi.org/10.1016/j.cell.2013.12.035.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Giridharan SSP, Caplan S. MICAL-family proteins: complex regulators of the actin cytoskeleton. Antioxid Redox Signal. 2014;20(13):2059–73. https://doi.org/10.1089/ars.2013.5487.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hung RJ, Terman JR. Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Cytoskeleton. 2011;68(8):415–33. https://doi.org/10.1002/cm.20527.

Article  PubMed  CAS  Google Scholar 

Wu H, Yesilyurt HG, Yoon J, Terman JR. The MICALs are a family of F-actin dismantling oxidoreductases conserved from drosophila to humans. Sci Rep. 2018;8(1):937. https://doi.org/10.1038/s41598-017-17943-5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vitali T, Maffioli E, Tedeschi G, Vanoni MA. Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains. Arch Biochem Biophys. 2016;593:24–37. https://doi.org/10.1016/j.abb.2016.01.016.

Article  PubMed  CAS  Google Scholar 

Zhang Z, Liu R, Wang Y, Wang Y, Shuai Y, Ke C, et al. Phosphorylation of MICAL2 by ARG promotes head and neck cancer tumorigenesis by regulating skeletal rearrangement. Oncogene. 2022;41(3):334–46. https://doi.org/10.1038/s41388-021-02101-z.

Article  PubMed  CAS  Google Scholar 

Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR. SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. Nat Cell Biol. 2013;15(12):1445–54. https://doi.org/10.1038/ncb2871.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, et al. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013;51(3):397–404. https://doi.org/10.1016/j.molcel.2013.06.019.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cai Y, Lu J, Tang F. Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT. J Cance. 2018;9(3):521–7. https://doi.org/10.7150/jca.22355.

Article  CAS  Google Scholar 

Wang Y, Deng W, Zhang Y, Sun S, Zhao S, Chen Y, et al. MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation. Acta Physiol (Oxf). 2018;222(2):12920. https://doi.org/10.1111/apha.12920.

Article  CAS  Google Scholar 

McDonald CA, Liu YY, Palfey BA. Actin stimulates reduction of the MICAL-2 monooxygenase domain. Biochemistry. 2013;52(35):6076–84. https://doi.org/10.1021/bi4008462.

Article  PubMed  CAS 

Comments (0)

No login
gif