The influence of cell source on the senescence of human mesenchymal stem/stromal cells

Wang Q, Wang Y, Chang C, Ma F, Peng D, Yang S, et al. Comparative analysis of mesenchymal stem/stromal cells derived from human induced pluripotent stem cells and the cognate umbilical cord mesenchymal stem/stromal cells. Heliyon. 2023;9(1): e12683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zomer HD, Vidane AS, Gonçalves NN, Ambrósio CE. Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives. Stem Cells Cloning. 2015;8:125–34.

PubMed  PubMed Central  Google Scholar 

Lue J, Lin G, Ning H, Xiong A, Lin CS, Glenn JS. Transdifferentiation of adipose-derived stem cells into hepatocytes: a new approach. Liver Int. 2010;30(6):913–22.

Article  CAS  PubMed  Google Scholar 

Liu H, Liu DQ, Li BW, Guan LD, Yan ZF, Li YL, et al. Human amniotic fluid-derived stem cells can differentiate into hepatocyte-like cells in vitro and in vivo. In Vitro Cell Dev Biol Anim. 2011;47(9):601–8.

Article  PubMed  Google Scholar 

Mareschi K, Rustichelli D, Comunanza V, De Fazio R, Cravero C, Morterra G, et al. Multipotent mesenchymal stem cells from amniotic fluid originate neural precursors with functional voltage-gated sodium channels. Cytotherapy. 2009;11(5):534–47.

Article  CAS  PubMed  Google Scholar 

Portmann-Lanz CB, Schoeberlein A, Portmann R, Mohr S, Rollini P, Sager R, et al. Turning placenta into brain: placental mesenchymal stem cells differentiate into neurons and oligodendrocytes. Am J Obstet Gynecol. 2010;202(3):294.e1-e11.

Article  PubMed  Google Scholar 

Xu Q, Hou W, Zhao B, Fan P, Wang S, Wang L, et al. Mesenchymal stem cells lineage and their role in disease development. Mol Med. 2024;30(1):207.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krampera M, Franchini M, Pizzolo G, Aprili G. Mesenchymal stem cells: from biology to clinical use. Blood Transfus. 2007;5(3):120–9.

PubMed  PubMed Central  Google Scholar 

Hoseini SM, Montazeri F. Cell origin and microenvironment: The players of differentiation capacity in human mesenchymal stem cells. Tissue Cell. 2025;93: 102709.

Article  CAS  PubMed  Google Scholar 

Doğan A. Embryonic stem cells in development and regenerative medicine. Adv Exp Med Biol. 2018;1079:1–15.

Article  PubMed  Google Scholar 

Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–76.

Article  CAS  PubMed  Google Scholar 

Thanaskody K, Jusop AS, Tye GJ, Wan-Kamarul-Zaman WS, Dass SA, Nordin F. MSCs vs iPSCs: potential in therapeutic applications. Front Cell Dev Biol. 2022;10:1005926.

Article  PubMed  PubMed Central  Google Scholar 

Weng Z, Wang Y, Ouchi T, Liu H, Qiao X, Wu C, et al. Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies. Stem Cells Transl Med. 2022;11(4):356–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banito A, Gil J. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep. 2010;11(5):353–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang G, Zhang Y. Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res. 2013;23(1):49–69.

Article  CAS  PubMed  Google Scholar 

Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015;35(2): e00191.

Article  PubMed  PubMed Central  Google Scholar 

Yu Y, Valderrama AV, Han Z, Uzan G, Naserian S, Oberlin E. Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3+ T reg induction capacity. Stem Cell Res Ther. 2021;12(1):138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hawkins KE, Corcelli M, Dowding K, Ranzoni AM, Vlahova F, Hau KL, et al. Embryonic stem cell-derived mesenchymal stem cells (MSCs) have a superior neuroprotective capacity over fetal MSCs in the hypoxic-ischemic mouse brain. Stem Cells Transl Med. 2018;7(5):439–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells: the International Society for cellular therapy position statement. Cytotherapy. 2006;8(4):315–7.

Article  CAS  PubMed  Google Scholar 

Eslaminejad MB, Nadri S. Murine mesenchymal stem cell isolated and expanded in low and high density culture system: surface antigen expression and osteogenic culture mineralization. In Vitro Cell Dev Biol-Anim. 2009;45(8):451–9.

Article  CAS  PubMed  Google Scholar 

Hoseini SM, Kalantar SM, Bahrami AR, Matin MM. Human amniocytes: a comprehensive study on morphology, frequency and growth properties of subpopulations from a single clone to the senescence. Cell Tissue Biol. 2020;14(2):102–12.

Article  Google Scholar 

Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, et al. Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) mesenchymal stromal cell committee position statement on nomenclature. Cytotherapy. 2019;21(10):1019–24.

Article  CAS  PubMed  Google Scholar 

Yi N, Zeng Q, Zheng C, Li S, Lv B, Wang C, et al. Functional variation among mesenchymal stem cells derived from different tissue sources. PeerJ. 2024;12: e17616.

Article  PubMed  PubMed Central  Google Scholar 

de Cássia NN, Mizukami A, Caliári-Oliveira C, Cominal JG, Rocha JLM, Covas DT, et al. Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies. Stem Cell Res Ther. 2019;10(1):131.

Article  Google Scholar 

Galipeau J, Sensébé L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hass R, Kasper C, Bohm S, Jacobs R. Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal. 2011;9:12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin JQ, Zhu J, Ankrum JA. Manufacturing of primed mesenchymal stromal cells for therapy. Nat Biomed Eng. 2019;3(2):90–104.

Article  CAS  PubMed  Google Scholar 

Abumaree M, Abomaray F, Alshabibi M, AlAskar A, Kalionis B. Immunomodulatory properties of human placental mesenchymal stem/stromal cells. Placenta. 2017;59:87–95.

Article  CAS  PubMed  Google Scholar 

Ventura Ferreira MS, Bienert M, Müller K, Rath B, Goecke T, Opländer C, et al. Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta. Stem Cell Res Ther. 2018;9(1):28.

Article  PubMed  PubMed Central  Google Scholar 

Musiał-Wysocka A, Kot M, Sułkowski M, Badyra B, Majka M. Molecular and functional verification of Wharton’s Jelly mesenchymal stem cells (WJ-MSCs) pluripotency. Int J Mol Sci. 2019;20(8):1807.

Article  PubMed  PubMed Central  Google Scholar 

Amati E, Sella S, Perbellini O, Alghisi A, Bernardi M, Chieregato K, et al. Generation of mesenchymal stromal cells from cord blood: evaluation of in vitro quality parameters prior to clinical use. Stem Cell Res Ther. 2017;8(1):14.

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