Liu Z, Zhuang Y, Fang L, Yuan C, Wang X, Lin K. Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis. Bioact Mater. 2023;22:423–52.

PubMed  Google Scholar 

Nguyen TH, Duong CM, Nguyen XH, Than UTT. Mesenchymal stem cell-derived extracellular vesicles for osteoarthritis treatment: extracellular matrix protection, chondrocyte and osteocyte physiology, pain and inflammation management. Cells. 2021;10(11):2887.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jang S, Lee K, Ju JH. Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci. 2021;22(5):2619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taruc-Uy RL, Lynch SA. Diagnosis and treatment of osteoarthritis. Prim Care. 2013;40(4):821–36.

Article  PubMed  Google Scholar 

Xia B, Di C, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int. 2014;95(6):495–505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Urabe F, Kosaka N, Ito K, Kimura T, Egawa S, Ochiya T. Extracellular vesicles as biomarkers and therapeutic targets for cancer. Am J Physiol Cell Physiol. 2020;318(1):C29-c39.

Article  CAS  PubMed  Google Scholar 

Lu Y, Liu D, Feng Q, Liu Z. Diabetic nephropathy: perspective on extracellular vesicles. Front Immunol. 2020;11:943.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ebata T, Terkawi MA, Kitahara K, Yokota S, Shiota J, Nishida Y, Iwasaki N. Noncanonical pyroptosis triggered by macrophage-derived extracellular vesicles in chondrocytes leading to cartilage catabolism in osteoarthritis. Arthritis Rheumatol. 2023;75(8):1358–69.

Article  CAS  PubMed  Google Scholar 

Li S, Stöckl S, Lukas C, Herrmann M, Brochhausen C, König MA, Grässel S. Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1β-induced catabolic responses of OA chondrocytes by upregulating miR-126–3p. Stem Cell Res Ther. 2021;12(1):252.

Article  PubMed  PubMed Central  Google Scholar 

Lu L, Wang J, Fan A, Wang P, Chen R, Lu L, Yin F. Synovial mesenchymal stem cell-derived extracellular vesicles containing microRN555A-26a-5p ameliorate cartilage damage of osteoarthritis. J Gene Med. 2021;23(11): e3379.

Article  CAS  PubMed  Google Scholar 

Yin B, Ni J, Witherel CE, Yang M, Burdick JA, Wen C, Wong SHD. Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics. Theranostics. 2022;12(1):207–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–7.

Article  CAS  PubMed  Google Scholar 

Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Ding C. Decreased miR-214–3p activates NF-κB pathway and aggravates osteoarthritis progression. EBioMedicine. 2021;65:103283.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye Y, Peng Y, He P, Zhang Q, Xu D. Urinary miRNAs as biomarkers for idiopathic osteonecrosis of femoral head: a multicentre study. J Orthop Translat. 2021;26:54–9.

Article  PubMed  Google Scholar 

Li Y, Liu Z, Song Y, Pan JJ, Jiang Y, Shi X, Yang GY. M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice. Theranostics. 2022;12(7):3553–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang P, Xiao T, Li J, Wang D, Sun J, Cheng C, Liu Q. miR-21 in EVs from pulmonary epithelial cells promotes myofibroblast differentiation via glycolysis in arsenic-induced pulmonary fibrosis. Environ Pollut. 2021;286:117259.

Article  CAS  PubMed  Google Scholar 

Shen Q, Huang Z, Ma L, Yao J, Luo T, Zhao Y, Jin Y. Extracellular vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis. Gut Microbes. 2022;14(1):2128604.

Article  PubMed  PubMed Central  Google Scholar 

Ishida K, Tanishima S, Tanida A, Nagira K, Mihara T, Takeda C, Nagashima H. Comprehensive analysis of microRNA expression in lumbar facet joint capsules and synovium of patients with osteoarthritis: Comparison between early-stage and late-stage osteoarthritis samples from a single individual. J Orthop Sci. 2023. https://doi.org/10.1016/j.joca.2022.02.155.

Article  PubMed  Google Scholar 

Li R, Duan W, Feng T, Gu C, Zhang Q, Long J, Chen L. Lycium barbarum polysaccharide inhibits ischemia-induced autophagy by promoting the biogenesis of neural stem cells-derived extracellular vesicles to enhance the delivery of miR-133a-3p. Chin Med. 2023;18(1):117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan Y, Chen Q, Li X, Zeng Z, Xiong W, Li G, Yi M. Pyroptosis: a new paradigm of cell death for fighting against cancer. J Exp Clin Cancer Res. 2021;40(1):153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zu Y, Mu Y, Li Q, Zhang ST, Yan HJ. Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res. 2019;14(1):307.

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Bai L. P2X7 receptor induces pyroptotic inflammation and cartilage degradation in osteoarthritis via NF-κB/NLRP3 crosstalk. Oxid Med Cell Longev. 2021;2021:8868361.

Article  PubMed  PubMed Central  Google Scholar 

Xie Z, Tang J, Chen Z, Wei L, Chen J, Liu Q. Human bone marrow mesenchymal stem cell-derived extracellular vesicles reduce inflammation and pyroptosis in acute kidney injury via miR-223-3p/HDAC2/SNRK. Inflamm Res. 2023;72(3):553–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Xu B. BMSC-derived exosomes ameliorate osteoarthritis by inhibiting pyroptosis of cartilage via delivering miR-326 targeting HDAC3 and STAT1//NF-κB p65 to chondrocytes. Mediators Inflamm. 2021;2021:9972805.

Article  PubMed  PubMed Central  Google Scholar 

Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, Jia Y, Hu D. Regulation of SIRT1 and its roles in inflammation. Front Immunol. 2022;13:831168.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rapagna S, Roberts BC, Solomon LB, Reynolds KJ, Thewlis D, Perilli E. Relationships between tibial articular cartilage, in vivo external joint moments and static alignment in end-stage knee osteoarthritis: a micro-CT study. J Orthop Res. 2022;40(5):1125–34.

Article  PubMed  Google Scholar 

An S, Hu H, Li Y, Hu Y. Pyroptosis plays a role in osteoarthritis. Aging Dis. 2020;11(5):1146–57.

Article  PubMed  PubMed Central  Google Scholar 

Ruiz GP, Camara H, Fazolini NPB, Mori MA. Extracellular miRNAs in redox signaling: Health, disease and potential therapies. Free Radic Biol Med. 2021;173:170–87.

Article  CAS  PubMed  Google Scholar 

Mori MA, Ludwig RG, Garcia-Martin R, Brandão BB, Kahn CR. Extracellular miRNAs: from biomarkers to mediators of physiology and disease. Cell Metab. 2019;30(4):656–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoesel B, Schmid JA. The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 2013;12:86.