Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am. 2015;24(3):491–508. https://doi.org/10.1016/j.soc.2015.03.006.

Article  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.

Article  CAS  Google Scholar 

Mauceri R, Bazzano M, Coppini M, Tozzo P, Panzarella V, Campisi G. Diagnostic delay of oral squamous cell carcinoma and the fear of diagnosis: a scoping review. Front Psychol. 2022;13:1009080. https://doi.org/10.3389/fpsyg.2022.1009080.

Article  PubMed  PubMed Central  Google Scholar 

Economopoulou P, de Bree R, Kotsantis I, Psyrri A. Diagnostic tumor markers in head and neck squamous cell carcinoma (HNSCC) in the clinical setting. Front Oncol. 2019;9:827. https://doi.org/10.3389/fonc.2019.00827.

Article  PubMed  PubMed Central  Google Scholar 

Conway DI, Purkayastha M, Chestnutt IG. The changing epidemiology of oral cancer: definitions, trends, and risk factors. Br Dent J. 2018;225(9):867–73. https://doi.org/10.1038/sj.bdj.2018.922.

Article  CAS  PubMed  Google Scholar 

Metsäniitty M, Hasnat S, Salo T, Salem A. Oral microbiota—a new frontier in the pathogenesis and management of head and neck cancers. Cancers. 2021;14(1):46. https://doi.org/10.3390/cancers14010046.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colonia-García A, Gutiérrez-Vélez M, Duque-Duque A, de Andrade CR. Possible association of periodontal disease with oral cancer and oral potentially malignant disorders: a systematic review. Acta Odontol Scand. 2020;78(7):553–9. https://doi.org/10.1080/00016357.2020.1774076.

Article  PubMed  Google Scholar 

Javed F, Warnakulasuriya S. Is there a relationship between periodontal disease and oral cancer? A systematic review of currently available evidence. Crit Rev Oncol Hematol. 2016;97:197–205. https://doi.org/10.1016/j.critrevonc.2015.08.018.

Article  PubMed  Google Scholar 

Eun YG, Lee JW, Kim SW, Hyun DW, Bae JW, Lee YC. Oral microbiome associated with lymph node metastasis in oral squamous cell carcinoma. Sci Rep. 2021;11(1):23176. https://doi.org/10.1038/s41598-021-02638-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mager DL. Bacteria and cancer: cause, coincidence or cure? A review. J Transl Med. 2006;4:14. https://doi.org/10.1186/1479-5876-4-14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Lee J, Park J, Gho YS. Gram-negative and Gram-positive bacterial extracellular vesicles. Semin Cell Dev Biol. 2015;40:97–104. https://doi.org/10.1016/j.semcdb.2015.02.006.

Article  CAS  PubMed  Google Scholar 

Fazal S, Lee R. Biomimetic bacterial membrane vesicles for drug delivery applications. Pharmaceutics. 2021;13(9):1430. https://doi.org/10.3390/pharmaceutics13091430.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Zhou H, Yang C, Wu Y, Zhou X, Liu H, Wang Y. Bacterial outer membrane vesicles as a platform for biomedical applications: an update. J Control Release. 2020;323:253–68.

Article  CAS  PubMed  Google Scholar 

Chronopoulos A, Kalluri R. Emerging role of bacterial extracellular vesicles in cancer. Oncogene. 2020;39(46):6951–60. https://doi.org/10.1038/s41388-020-01509-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amatya SB, Salmi S, Kainulainen V, Karihtala P, Reunanen J. Bacterial extracellular vesicles in gastrointestinal tract cancer: an unexplored territory. Cancers. 2021;13(21):5450. https://doi.org/10.3390/cancers13215450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Damek-Poprawa M, et al. Targeted inhibition of CD133+ cells in oral cancer cell lines. J Dent Res. 2011;90(5):638–45. https://doi.org/10.1177/0022034510393511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwanaga K, et al. Local delivery system of cytotoxic agents to tumors by focused sonoporation. Cancer Gene Ther. 2007;14(4):354–63. https://doi.org/10.1038/sj.cgt.7701026.

Article  CAS  PubMed  Google Scholar 

Teshima R, Hanada K, Akada J, Kawano K, Yamaoka Y. Aggregatibacter actinomycetemcomitans infection causes DNA double-strand breaks in host cells. Genes Cells. 2018;23(4):264–73. https://doi.org/10.1111/gtc.12570.

Article  CAS  PubMed  Google Scholar 

Yamamoto K, Tominaga K, Sukedai M, Okinaga T, Iwanaga K, Nishihara T, Fukuda J. Delivery of cytolethal distending toxin B induces cell cycle arrest and apoptosis in gingival squamous cell carcinoma in vitro. Eur J Oral Sci. 2004;112(5):445–51. https://doi.org/10.1111/j.1600-0722.2004.00157.x.

Article  CAS  PubMed  Google Scholar 

Jain S, et al. Lipopolysaccharide (LPS) enhances prostate cancer metastasis potentially through NF-κB activation and recurrent dexamethasone administration fails to suppress it in vivo. Prostate. 2019;79(2):168–82. https://doi.org/10.1002/pros.23722.

Article  CAS  PubMed  Google Scholar 

Song W, et al. Trapping of Lipopolysaccharide to Promote Immunotherapy against colorectal cancer and attenuate liver metastasis. Adv Mater. 2018;30(52):e1805007. https://doi.org/10.1002/adma.201805007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shetab Boushehri MA, Lamprecht A. TLR4-based Immunotherapeutics in cancer: a review of the achievements and shortcomings. Mol Pharm. 2018;15(11):4777–800. https://doi.org/10.1021/acs.molpharmaceut.8b00691.

Article  CAS  PubMed  Google Scholar 

Monasterio G, et al. O-Polysaccharide plays a major role on the virulence and immunostimulatory potential of Aggregatibacter actinomycetemcomitans during periodontal infection. Front Immunol. 2020;11:591240. https://doi.org/10.3389/fimmu.2020.591240.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindholm M, Metsäniitty M, Granström E, Oscarsson J. Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans. J Oral Microbiol. 2020;12(1):1747857. https://doi.org/10.1080/20002297.2020.1747857.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh S, Singh AK. Porphyromonas gingivalis in oral squamous cell carcinoma: a review. Microbes Infect. 2022;24(3):104925. https://doi.org/10.1016/j.micinf.2021.104925.

Article  CAS  PubMed  Google Scholar 

Metsäniitty M, Hasnat S, Öhman C, Salo T, Eklund KK, Oscarsson J, Salem A. Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: a comparative in vitro study. Arch Microbiol. 2024;206(6):244. https://doi.org/10.1007/s00203-024-03976-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Liu S, Liu J, Miao L, Zhang S, Pan Y. sRNA23392 packaged by Porphyromonas gingivalis outer membrane vesicles promotes oral squamous cell carcinomas migration and invasion by targeting desmocollin-2. Mol Oral Microbiol. 2021;36(3):182–91. https://doi.org/10.1111/omi.12334.

Article  CAS  PubMed