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Structural insights into VAChT neurotransmitter recognition and inhibition
Structural insights into VAChT neurotransmitter recognition and inhibition
Acetylcholine (ACh) is an excitatory neurotransmitter with a wide variety of functions. In the centra...
AI accurately predicting the structure of biomolecular interactions
In two recent studies published in Nature and Science, researchers successfully developed unified AI ...
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
Pyroptosis: palmitoylation regulates GSDMD activation and pore formation
Gasdermin D (GSDMD) is the pore-forming executor of pyroptosis and cytokine secretion during inflamma...
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope wi...
ANT2: the first mammalian mitochondrial RNA transport translocon
ANT2: the first mammalian mitochondrial RNA transport translocon
Despite the crucial roles of mitochondrial RNA transport in maintaining mitochondrial functionality, ...
Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors
Combination therapy of KRAS G12V mRNA vaccine and pembrolizumab: clinical benefit in patients with advanced solid tumors
mRNA-based therapeutics have gained the public’s attention in the post-COVID era. The application of ...
Localized, highly efficient secretion of signaling proteins by migrasomes
Localized, highly efficient secretion of signaling proteins by migrasomes
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in...
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA
Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA
We thank SKLB West China Cryo-EM Center of Sichuan University, Cryo-EM Facility of Westlake University, and Kobilka Cryo-E...
MFSD7c functions as a transporter of choline at the blood–brain barrier
MFSD7c functions as a transporter of choline at the blood–brain barrier
Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler syndrome. Here, we used Mfsd7c kno...
Sensing the toxic aluminum cations in acidic soils
Sensing the toxic aluminum cations in acidic soils
Plant cells are regularly challenged by harmful pathogens and toxins in the environment, and they mus...
B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis
B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis
Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive ...
Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity
Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity
Synthetic biology confers new functions to hosts by introducing exogenous genetic elements, yet rebuilding complex traits ...
Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice
Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder featured by left ventricular (LV) ...
CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization
CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization
Tonic signaling of chimeric antigen receptors (CARs) plays a pivotal role in governing CAR-T cell fit...
Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection
Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection
Group 2 innate lymphoid cells (ILC2s), known for their role in defending against parasites and regula...
Publisher Correction: Sanofi-Cell Research outstanding paper award of 2022
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Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Caught in the middle: MARCH5 mediates PD-1-induced IL-2R degradation
Blockade of the PD-L1/PD-1 pathway in combination of IL-2 therapy appears to yield synergistic anti-t...
A precision counterstrike on central nervous system autoimmunity
A precision counterstrike on central nervous system autoimmunity
Autoantibodies targeting the N-methyl-D-aspartate receptor (NMDAR) induce debilitating neuropsychiatr...
Sanofi-Cell Research outstanding paper award of 2022
Sanofi-Cell Research outstanding paper award of 2022
We are pleased to announce the winners of the 2022 Sanofi-Cell Research Outstanding Research Article ...
Rpd3S meets the nucleosome
Rpd3S meets the nucleosome
Two recent reports in Cell Research present cryo-electron microscopy structures of the Rpd3S HDAC com...
Flooding plant apoplast through water and solute channels
Flooding plant apoplast through water and solute channels
Inducing water-soaking symptoms is a key early step during the pathogenesis of many fungal, oomycete,...
Decoding Golgiphagy: selective recycling under stress
Decoding Golgiphagy: selective recycling under stress
In a recent study, Hickey et al. use quantitative proteomics to show that ER-phagy and Golgiphagy are...
Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex
Structural insights into asymmetric activation of the calcium-sensing receptor–Gq complex
We thank the Cryo-EM Center at University of Science and Technology of China for the support of cryo-EM data collection. T...
Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes
Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes
RNA-guided DNA endonucleases are broadly associated with and play critical roles in prokaryotic adaptive ...
Human SIDT1 mediates dsRNA uptake via its phospholipase activity
Human SIDT1 mediates dsRNA uptake via its phospholipase activity
Author notesThese authors contributed equally: Cai-Rong Sun, Da Xu, Fengrui Yang.Authors and AffiliationsSchool of Life Sc...
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity
Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity
In the nematode Caenorhabditis elegans, the systemic RNA interference defective protein 1 (SID-1) plays a...
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity
Combination therapy with PD-1 blockade and IL-2 substantially improves anti-tumor efficacy comparing to monotherapy. The u...
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
NR5A2 connects zygotic genome activation to the first lineage segregation in totipotent embryos
Zygotic genome activation (ZGA) marks the beginning of the embryonic program for a totipotent embryo, which gives rise to ...
Time and place: mapping human prenatal macrophages across tissues
Time and place: mapping human prenatal macrophages across tissues
In a recent Cell paper, Wang et al. characterized human immune cells at the single-cell level across 19 t...
Hematopoietic memory of severe COVID-19 infection
Hematopoietic memory of severe COVID-19 infection
A new study describes that individuals who recovered from severe coronavirus disease-19 (COVID-19) exhibi...
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