SCI Abstract

search
+
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
A Quinoxaline Derivative as a New Therapeutic Agent for Sepsis through Suppression of TLR4 Signaling Pathways
Sepsis is a severe systemic inflammatory syndrome and one of the leading causes of global morbidity and mortality. Preclin...
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Acute and Long-Term Consequences of Neonatal NMDA Blockade in the Knock-Out Mouse
Neuron–microglia communication through the fractalkine pathway is a critical factor mediating microglial proliferati...
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages
Sepsis-induced acute lung injury (ALI) is a life-threatening condition with high mortality rates, and its underlying mecha...
Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis
Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis
Granulomatous mastitis (GM) is a form of non-lactational breast inflammation that is closely associated with autoimmune pr...
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway
This study investigates the effect and underlying mechanism of targeting SLC7A11 in mitigating dextran sulfate sodium (DSS...
Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury
Multi-omics Analysis Reveals the Propagation Mechanism of Ferroptosis in Acute Kidney Injury
Acute kidney injury (AKI) is a prevalent and critical clinical condition characterized by high morbidity and mortality. Re...
Nonstructural Protein 1 Mediates HMGB1 Release by Targeting Histone H1.0 After Respiratory Syncytial Virus Infection In Vivo and In Vitro
Nonstructural Protein 1 Mediates HMGB1 Release by Targeting Histone H1.0 After Respiratory Syncytial Virus Infection In Vivo and In Vitro
High mobility group box-1 (HMGB1) is implicated in airway inflammation during the late phase of respiratory syncytial viru...
Sodium–Glucose Cotransporter 2 Inhibitor Ameliorate Angiotensin II-Induced Hypertension and Vascular Injury by Upregulating FGF21
Sodium–Glucose Cotransporter 2 Inhibitor Ameliorate Angiotensin II-Induced Hypertension and Vascular Injury by Upregulating FGF21
Clinical trials have demonstrated Sodium-glucose cotransporter 2 inhibitors (SGLT2i) antihypertensive effects, yet their u...
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head
Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head
Glucocorticoids-induced osteonecrosis of the femoral head (GONFH) is characterized by progressive cartilage degeneration, ...
Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model
Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model
Allergen immunotherapy (AIT) is the only treatment that can alter the course of allergic diseases by inducing immune toler...
LncRNA SNHG7/miR-181b-5p/TLR4 Activates Inflammation And Promotes Pyroptosis Through NF-κB Signaling in Diabetic Nephropathy
LncRNA SNHG7/miR-181b-5p/TLR4 Activates Inflammation And Promotes Pyroptosis Through NF-κB Signaling in Diabetic Nephropathy
MiR-181b-5p plays a critical role in the pyroptosis and injury of kidney tubular cells in diabetic kidney disease (DKD). T...
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy
Tubulointerstitial fibrosis (TIF), a critical pathological hallmark in progressive chronic kidney disease (CKD), may be po...
The Evolution and Recurrence of Chronic Subdural Hematoma was Associated with Different Distribution of Macrophage M1/M2 Polarization
The Evolution and Recurrence of Chronic Subdural Hematoma was Associated with Different Distribution of Macrophage M1/M2 Polarization
The pathogenesis of chronic subdural hematoma (CSDH) has traditionally been associated with inflammation, but the efficacy...
High level expression of OSBPL11 is associated with atherosclerosis and Alzheimer's disease
High level expression of OSBPL11 is associated with atherosclerosis and Alzheimer's disease
With the global aging population, the incidence of aging-related diseases such as Alzheimer's disease (AD) and atheros...
The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis
The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis
Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of tooth-supporting tissues. ...
March6 Protects Against Acute Kidney Injury by Suppressing Renal Tubular Epithelial Cell Ferroptosis Through the Destabilization of P53 and ACSL4 Proteins
March6 Protects Against Acute Kidney Injury by Suppressing Renal Tubular Epithelial Cell Ferroptosis Through the Destabilization of P53 and ACSL4 Proteins
Acute kidney injury (AKI) progression involves significant contributions from renal tubular epithelial cell ferroptosis. M...
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway
XBP1 Knockdown Alleviates Pyroptosis and Promotes Th17/Treg Imbalance in Periodontitis by Inhibiting the IL-17 Signaling Pathway
Periodontitis is a long-lasting inflammatory condition that significantly affects people's quality of life. This resea...
Activation of Human FPR2 with AT-RvD1 Resolves Acute Sialadenitis in Vivo
Activation of Human FPR2 with AT-RvD1 Resolves Acute Sialadenitis in Vivo
Previous studies demonstrated that activation of the mouse G protein-coupled formyl peptide receptor 2 (mFpr2) with aspiri...
Critical Role of Cholic Acid in the Development of iHFC Diet-induced MASH in TSNO Mice
Critical Role of Cholic Acid in the Development of iHFC Diet-induced MASH in TSNO Mice
A high-fat/cholesterol/cholate-based (iHFC) diet induces pathological changes in Tsumura-Suzuki non-obese (TSNO) mice, res...
AR Deficiency Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Macrophage M1 Polarization and Inflammatory Cytokine Secretion
AR Deficiency Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Macrophage M1 Polarization and Inflammatory Cytokine Secretion
Acute lung injury (ALI) constitutes a major public health concern, with sepsis contributing to up to 50% of ALI cases in t...
Identification of Key Genes Related to Immune-Lipid Metabolism in Skin Barrier Damage and Analysis of Immune Infiltration
Identification of Key Genes Related to Immune-Lipid Metabolism in Skin Barrier Damage and Analysis of Immune Infiltration
Several physical and chemical factors regulate skin barrier function. Skin barrier dysfunction causes many inflammatory sk...
Characterizing Non-T2 Asthma: Key Pathways and Molecular Implications Indicative of Attenuated Th2 Response
Characterizing Non-T2 Asthma: Key Pathways and Molecular Implications Indicative of Attenuated Th2 Response
Non-Type 2 (non-T2) asthma is characterized by a lack of allergic sensitization and normal to low total IgE levels. We aim...
Pharmacological Inhibition of Phosphoglycerate Kinase 1 Reduces OxiDative Stress and Restores Impaired Autophagy in Experimental Acute Pancreatitis
Pharmacological Inhibition of Phosphoglycerate Kinase 1 Reduces OxiDative Stress and Restores Impaired Autophagy in Experimental Acute Pancreatitis
Damage to pancreatic acinar cells (PAC) and intracellular metabolic disturbances play crucial roles in pancreatic necrosis...
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI
Nicotinamide N-oxide Inhibits Microglial Pyroptosis by Upregulating Mitophagy and Alleviates Neural Damage in Rats after TBI
Traumatic brain injury (TBI) is a severe injury characterized by neuroinflammation and oxidative stress. NAMO (Nicotinamid...
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis
Atorvastatin Alleviates Age-Related Macular Degeneration via AIM2-Regulated Pyroptosis
The underlying causes of age-related macular degeneration (AMD) remain elusive and treatment options of it are limited, wh...
Acetyl 11-Keto Beta-Boswellic Acid Improves Neurological Functions in a Mouse Model of Multiple Sclerosis
Acetyl 11-Keto Beta-Boswellic Acid Improves Neurological Functions in a Mouse Model of Multiple Sclerosis
Acetyl-11-keto-β-boswellic acid is one of the main active components of Boswellia sp. resin with the most potent anti...
Multiple Machine Learning Identifies Key Gene PHLDA1 Suppressing NAFLD Progression
Multiple Machine Learning Identifies Key Gene PHLDA1 Suppressing NAFLD Progression
Non-alcoholic fatty liver disease (NAFLD) poses a serious global health threat, with its progression mechanisms not yet fu...
GZMK Facilitates Experimental Rheumatoid Arthritis Progression by Interacting with CCL5 and Activating the ERK Signaling
GZMK Facilitates Experimental Rheumatoid Arthritis Progression by Interacting with CCL5 and Activating the ERK Signaling
Synovial over-proliferation is a key event in the progression of rheumatoid arthritis (RA) disease. Ferroptosis may be ess...
Inhibition of GDNF-Driven Macrophage-to-Myofibroblast Transition Protects Against Colitis-Associated Intestinal Fibrosis
Inhibition of GDNF-Driven Macrophage-to-Myofibroblast Transition Protects Against Colitis-Associated Intestinal Fibrosis
Glial cell line-derived neurotrophic factor (GDNF) has been demonstrated to promote the development of liver fibrosis, but...
USP30-AS1 Suppresses Colon Cancer Cell Inflammatory Response Through NF-κB/MYBBP1A Signaling
USP30-AS1 Suppresses Colon Cancer Cell Inflammatory Response Through NF-κB/MYBBP1A Signaling
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and poses a significant threat to human health...
Load More
format_indent_increase