Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous Mastitis

Kessler, E., and Y. Wolloch. 1972. Granulomatous mastitis: A lesion clinically simulating carcinoma. American journal of clinical pathology 58:642–646.

Article  PubMed  CAS  Google Scholar 

Steuer, A.B., M.J. Stern, G. Cobos, C. Castilla, K.A. Joseph, M.K. Pomeranz, and A.N. Femia. 2020. Clinical Characteristics and Medical Management of Idiopathic Granulomatous Mastitis. JAMA dermatology 156:460–464.

Article  PubMed  PubMed Central  Google Scholar 

Yuan, Q.Q., S.Y. Xiao, O. Farouk, Y.T. Du, F. Sheybani, Q.T. Tan, S. Akbulut, K. Cetin, A. Alikhassi, R.J. Yaghan, I. Durur-Subasi, F. Altintoprak, T.I. Eom, F. Alper, M. Hasbahceci, D. Martínez-Ramos, P.S. Oztekin, A. Kwong, C.W. Pluguez-Turull, K.E. Brownson, S. Chandanwale, M. Habibi, L.Y. Lan, R. Zhou, X.T. Zeng, J. Bai, J.W. Bai, Q.R. Chen, X. Chen, X.M. Zha, W.J. Dai, Z.J. Dai, Q.Y. Feng, Q.J. Gao, R.F. Gao, B.S. Han, J.X. Hou, W. Hou, H.Y. Liao, H. Luo, Z.R. Liu, J.H. Lu, B. Luo, X.P. Ma, J. Qian, J.Y. Qin, W. Wei, G. Wei, L.Y. Xu, H.C. Xue, H.W. Yang, W.G. Yang, C.J. Zhang, F. Zhang, G.X. Zhang, S.K. Zhang, S.Q. Zhang, Y.Q. Zhang, Y.P. Zhang, S.C. Zhang, D.W. Zhao, X.M. Zheng, L.W. Zheng, G.R. Xu, W.B. Zhou, and G.S. Wu. 2022. Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition). Military Medical Research 9: 20.

Martinez-Ramos, D., L. Simon-Monterde, C. Suelves-Piqueres, R. Queralt-Martin, L. Granel-Villach, J.M. Laguna-Sastre, M.J. Nicolau, and J. Escrig-Sos. 2019. Idiopathic granulomatous mastitis: A systematic review of 3060 patients. The breast journal 25:1245–1250.

Article  PubMed  Google Scholar 

Hua, C., F. Li, Y. Shi, Y. Xu, M. Zhu, Y. Wang, X. Zhou, and S. Liu. 2024. Long-Term Outcomes of Traditional Chinese Medicine in the Treatment of Granulomatous Lobular Mastitis: A Two-Year Follow-Up Study on Recurrence and New Occurrence Rates with Analysis of Risk Factors. Journal of inflammation research 17:7389–7399.

Article  PubMed  PubMed Central  Google Scholar 

Nickerson, S.C. 1989. Immunological aspects of mammary involution. Journal of dairy science 72:1665–1678.

Article  PubMed  CAS  Google Scholar 

Humphreys, R.C., B. Bierie, L. Zhao, R. Raz, D. Levy, and L. Hennighausen. 2002. Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli. Endocrinology 143:3641–3650.

Article  PubMed  CAS  Google Scholar 

Gopalakrishnan Nair, C., P. Hiran, R.R. Menon. Jacob, and Misha. 2015. Inflammatory diseases of the non-lactating female breasts. International journal of surgery (London, England) 13:8–11.

Article  PubMed  CAS  Google Scholar 

Yigitbasi, M.R., G. Guntas, T. Atak, C. Sonmez, H. Yalman, and H. Uzun. 2017. The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer. Journal of investigative surgery : The official journal of the Academy of Surgical Research 30:272–276.

Article  PubMed  Google Scholar 

Kong, C., C. Zhang, Y. Wu, Z. Zeng, H. Yu, J. Zeng, S. Lei, J. He, and P. Fan. 2020. The expression and meaning of CD68, CD163, CD57, and IgG4 in granulomatous lobular mastitis. Gland surgery 9:936–949.

Article  PubMed  PubMed Central  Google Scholar 

Zhou, Y., J. Gong, X. Deng, L. Shen, and L. Liu. 2024. Novel insights: Crosstalk with non-puerperal mastitis and immunity. Frontiers in immunology 15:1431681.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou, Y., J. Wu, L. Ma, B. Wang, T. Meng, H. Chen, and M. Ye. 2023. Differences and significance of peripheral blood interleukin-6 expression between patients with granulomatous lobular mastitis and those with benign breast tumors. Frontiers in medicine 10:1273406.

Article  PubMed  PubMed Central  Google Scholar 

Koksal, H., H. Vatansev, H. Artac, and N. Kadoglou. 2020. The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis. Clinical rheumatology 39:1671–1677.

Article  PubMed  Google Scholar 

Chiu, L.W., K. Goodwin, P. Vohra, and E. Amerson. 2022. Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-α Inhibitor, Adalimumab. European journal of breast health 18:94–101.

Article  PubMed  Google Scholar 

Kamat, S., W. Schaffenburg, and M. Bongiorno. 2022. Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab. Dermatopathology (Basel, Switzerland) 9:408–412.

PubMed  Google Scholar 

Liu, Y.M., J.Y. Ge, Y.F. Chen, T. Liu, L. Chen, C.C. Liu, D. Ma, Y.Y. Chen, Y.W. Cai, Y.Y. Xu, Z.M. Shao, and K.D. Yu. 2023. Combined Single-Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early Dissemination. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10: e2205395.

Cheng, C., W. Chen, H. Jin, and X. Chen. 2023. A Review of Single-Cell RNA-Seq Annotation, Integration, and Cell-Cell Communication. Cells 12:1970.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhao, X., J. Chen, S. Yin, J. Shi, M. Zheng, C. He, H. Meng, Y. Han, J. Han, J. Guo, Z. Yuan, and Y. Wang. 2022. The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis. Frontiers in oncology 12 : 992468.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu, C., T. Li, Y. Xu, X. Zhang, F. Li, J. Bai, J. Chen, W. Jiang, K. Yang, Q. Ou, X. Li, P. Wang, and Y. Zhang. 2023. Cell Marker 2.0: An updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic acids research 51:D870–D876.

Article  PubMed  CAS  Google Scholar 

Franzén, O., L.M. Gan, and J. Björkegren. 2019. PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data. Database : the journal of biological databases and curation 2019: baz046.

Gulati, G.S., S.S. Sikandar, D.J. Wesche, A. Manjunath, A. Bharadwaj, M.J. Berger, F. Ilagan, A.H. Kuo, R.W. Hsieh, S. Cai, M. Zabala, F.A. Scheeren, N.A. Lobo, D. Qian, F.B. Yu, F.M. Dirbas, M.F. Clarke, and A.M. Newman. 2020. Single-cell transcriptional diversity is a hallmark of developmental potential. Science 367:405–411.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Andreatta, M., and S.J. Carmona. 2021. UCell: Robust and scalable single-cell gene signature scoring. Computational and structural biotechnology journal 19:3796–3798.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu, T., E. Hu, S. Xu, M. Chen, P. Guo, Z. Dai, T. Feng, L. Zhou, W. Tang, L. Zhan, X. Fu, S. Liu, X. Bo, and G. Yu. 2021. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation (Cambridge (Mass.)) 2: 100141.

Xu, S., E. Hu, Y. Cai, Z. Xie, X. Luo, L. Zhan, W. Tang, Q. Wang, B. Liu, R. Wang, W. Xie, T. Wu, L. Xie, and G. Yu. 2024. Using clusterProfiler to characterize multiomics data. Nature protocols 19:3292–3320.

Article  PubMed  CAS  Google Scholar 

Reimand, J., R. Isserlin, V. Voisin, M. Kucera, C. Tannus-Lopes, A. Rostamianfar, L. Wadi, M. Meyer, J. Wong, C. Xu, D. Merico, and G.D. Bader. 2019. Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap. Nature protocols 14:482–517.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hänzelmann, S., R. Castelo, and J. Guinney. 2013. GSVA: Gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7.

Article  PubMed  PubMed Central  Google Scholar 

Cao, G., X. Xuan, Y. Li, J. Hu, R. Zhang, H. Jin, and H. Dong. 2023. Single-cell RNA sequencing reveals the vascular smooth muscle cell phenotypic landscape in aortic aneurysm. Cell communication and signaling : CCS 21:113.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu, F., J. Fan, Y. He, A. Xiong, J. Yu, Y. Li, Y. Zhang, W. Zhao, F. Zhou, W. Li, J. Zhang, X. Zhang, M. Qiao, G. Gao, S. Chen, X. Chen, X. Li, L. Hou, C. Wu, C. Su, S. Ren, M. Odenthal, R. Buettner, N. Fang, and C. Zhou. 2021. Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer. Nature communications 12:2540.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou, F., L. Liu, F. Wang, L. Yu, Y. Xiang, C. Zheng, S. Huang, Z. Yang, and Z. Yu. 2024. Periductal Mastitis, a Disease with Distinct Clinicopathological Features from Granulomatous Lobular Mastitis. Journal of inflammation research 17:3815–3823.

Article  PubMed  PubMed Central  Google Scholar 

Afkarian, M., J.R. Sedy, J. Yang, N.G. Jacobson, N. Cereb, S.Y. Yang, T.L. Murphy, and K.M. Murphy. 2002. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nature immunology 3:549–557.

Article  PubMed  CAS  Google Scholar 

Gorabi, A.M., S. Hajighasemi, N. Kiaie, S.M. Gheibi Hayat, T. Jamialahmadi, T.P. Johnston, and A. Sahebkar. 2020. The pivotal role of CD69 in autoimmunity. Journal of autoimmunity 111 : 102453.

Article  PubMed  CAS  Google Scholar 

Kamdar, K., V. Nguyen, and R.W. DePaolo. 2013. Toll-like receptor signaling and regulation of intestinal immunity. Virulence 4:207–212.

Article  PubMed 

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