Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma

Succony L, Rassl DM, Barker AP, McCaughan FM, Rintoul RC. Adenocarcinoma spectrum lesions of the lung: Detection, pathology and treatment strategies. Cancer Treat Rev. 2021;99: 102237. https://doi.org/10.1016/j.ctrv.2021.102237.

Article  CAS  PubMed  Google Scholar 

Xing P, Wang S, Cao Y, Liu B, Zheng F, Guo W, Huang J, Zhao Z, Yang Z, Lin X, Sang L, Liu Z. Treatment strategies and drug resistance mechanisms in adenocarcinoma of different organs. Drug Resist Updat. 2023;71: 101002. https://doi.org/10.1016/j.drup.2023.101002.

Article  CAS  PubMed  Google Scholar 

Tsvetkova D, Ivanova S. Application of approved cisplatin derivatives in combination therapy against different cancer diseases. Molecules. 2022;27(8):2466.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang J, Lu T, Chen Z, Zhan C, Wang Q. Mechanisms of resistance to pemetrexed in non-small cell lung cancer. Transl Lung Cancer Res. 2019;8(6):1107–18. https://doi.org/10.21037/tlcr.2019.10.14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallen M, Aqil F, Spencer W, Gupta RC. Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics. Cancer Lett. 2023;561: 216141. https://doi.org/10.1016/j.canlet.2023.216141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KU, Kim WH, Jeong CH, Yi DY, Min H. More than nutrition: Therapeutic potential of breast milk-derived exosomes in cancer. Int J Mol Sci. 2020;21(19):7327.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sedykh S, Kuleshova A, Nevinsky G. Milk exosomes: Perspective agents for anticancer drug delivery. Int J Mol Sci. 2020;21(18):6646.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aqil F, Munagala R, Jeyabalan J, Agrawal AK, Kyakulaga AH, Wilcher SA, Gupta RC. Milk exosomes - Natural nanoparticles for siRNA delivery. Cancer Lett. 2019;449:186–95. https://doi.org/10.1016/j.canlet.2019.02.011.

Article  CAS  PubMed  Google Scholar 

Zhang A, Huang J, Liu Y, Gong H, Guan F, Li W, Han F, Wang Y. Hyaluronic acid application strategies for plant bioactive component delivery: A review. Int J Biol Macromol. 2024;282(Pt 3): 137129. https://doi.org/10.1016/j.ijbiomac.2024.137129.

Article  CAS  PubMed  Google Scholar 

Li D, Gong L, Lin H, Yao S, Yin Y, Zhou Z, Shi J, Wu Z, Huang Z. Hyaluronic acid-coated bovine milk exosomes for achieving tumor-specific intracellular delivery of miRNA-204. Cells. 2022;11(19):3065.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Liu X, He L, Yang J, Pei F, Li W, Liu S, Chen Z, Xie G, Xu B, Ting X, Zhang Z, Jin T, Liu X, Zhang W, Yuan S, Yang Z, Wu C, Zhang Y, Yang X, Yi X, Liang J, Shang Y, Sun L. ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nat Commun. 2017;8(1):691. https://doi.org/10.1038/s41467-017-00702-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, He L, Tang Y, Li D, Yang Y, Zeng Z. Development and validation of a nomogram with an epigenetic signature for predicting survival in patients with lung adenocarcinoma. Aging (Albany NY). 2020;12(22):23200–16. https://doi.org/10.18632/aging.104090.

Article  CAS  PubMed  Google Scholar 

Alam A, Locher KP. Structure and Mechanism of Human ABC Transporters. Annu Rev Biophys. 2023;52:275–300. https://doi.org/10.1146/annurev-biophys-111622-091232.

Article  CAS  PubMed  Google Scholar 

Diaz MA, Fusco M, Benitez CA, Gayet F, Garcia L, Victoria L, Jaramillo S, Bayo J, Zubieta MR, Rizzo MM, Piccioni F, Malvicini M. Targeting hyaluronan metabolism-related molecules associated with resistant tumor-initiating cells potentiates chemotherapy efficacy in lung cancer. Sci Rep. 2024;14(1):16803. https://doi.org/10.1038/s41598-024-66914-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou Y, Zhu Q, Li Z, Peng Y, Yu X, Yuan B, Liu Y, Liu Y, Yin L, Peng Y, Jiang Z, Li J, Xie B, Duan Y, Tan G, Gulina K, Gong Z, Sun L, Fan X, Li X. The FOXM1-ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cells. Cell Death Dis. 2017;8(3): e2659. https://doi.org/10.1038/cddis.2017.53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang W, Chen K, Lu Y, Zhang D, Cheng Y, Li L, Huang W, He G, Liao H, Cai L, Tang Y, Zhao L, Pan M. ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma. Neoplasia. 2021;23(12):1227–39. https://doi.org/10.1016/j.neo.2021.11.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong L, Zhou H, Zhang Y, Wang C, Fu K, Ma C, Li Y. Preparation of Phillygenin-Hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect. Mater Today Bio. 2023;23: 100804. https://doi.org/10.1016/j.mtbio.2023.100804.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang D, Ochi N, Takigawa N, Tanimoto Y, Chen Y, Ichihara E, Hotta K, Tabata M, Tanimoto M, Kiura K. Establishment of pemetrexed-resistant non-small cell lung cancer cell lines. Cancer Lett. 2011;309(2):228–35. https://doi.org/10.1016/j.canlet.2011.06.006.

Article  CAS  PubMed  Google Scholar 

Yang Y, Fan H, Liu H, Lou X, Xiao N, Zhang C, Chen H, Chen S, Gu H, Liu H, Wan J. NOP2 facilitates EZH2-mediated epithelial-mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression. Cell Death Dis. 2024;15(7):506. https://doi.org/10.1038/s41419-024-06899-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Zuo R, He Y, Gong W, Wang Y, Chen L, Luo Y, Zhang C, Liu Z, Chen P, Guo H. PD-L1 induces autophagy and primary resistance to EGFR-TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway. Cell Death Dis. 2024;15(8):555. https://doi.org/10.1038/s41419-024-06945-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pullan JE, Confeld MI, Osborn JK, Kim J, Sarkar K, Mallik S. Exosomes as drug carriers for cancer therapy. Mol Pharm. 2019;16(5):1789–98. https://doi.org/10.1021/acs.molpharmaceut.9b00104.

Article  CAS  PubMed  Google Scholar 

Sagbas Suner S, Ari B, Onder FC, Ozpolat B, Ay M, Sahiner N. Hyaluronic acid and hyaluronic acid: Sucrose nanogels for hydrophobic cancer drug delivery. Int J Biol Macromol. 2019;126:1150–7. https://doi.org/10.1016/j.ijbiomac.2019.01.021.

Article  CAS  PubMed  Google Scholar 

Liu J, Ren L, Li S, Li W, Zheng X, Yang Y, Fu W, Yi J, Wang J, Du G. The biology, function, and applications of exosomes in cancer. Acta Pharm Sin B. 2021;11(9):2783–97. https://doi.org/10.1016/j.apsb.2021.01.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Timofeeva AM, Paramonik AP, Sedykh SS, Nevinsky GA. Milk exosomes: Next-generation agents for delivery of anticancer drugs and therapeutic nucleic acids. Int J Mol Sci. 2023;24(12):10194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li D, Yao S, Zhou Z, Shi J, Huang Z, Wu Z. Hyaluronan decoration of milk exosomes directs tumor-specific delivery of doxorubicin. Carbohydr Res. 2020;493: 108032. https://doi.org/10.1016/j.carres.2020.108032.

Article  CAS  PubMed  Google Scholar 

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