Meltzer PS, Helman LJ. New horizons in the treatment of osteosarcoma. N Engl J Med. 2021;385:2066–76. https://doi.org/10.1056/NEJMra2103423.

Article  CAS  PubMed  Google Scholar 

Khalili-Tanha G, Moghbeli M. Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells. Cell Mol Biol Lett. 2021. https://doi.org/10.1186/s11658-021-00282-9.

Article  PubMed  PubMed Central  Google Scholar 

Bian ZJ, Shan HJ, Zhu YR, Shi C, Chen MB, Huang YM, Wang XD, Zhou XZ, Cao C. Identification of Gαi3 as a promising target for osteosarcoma treatment. Int J Biol Sci. 2022. https://doi.org/10.7150/ijbs.68861.

Article  PubMed  PubMed Central  Google Scholar 

Bao Z, Zhu R, Fan H, Ye Y, Li T, Chai D. Aberrant expression of SPAG6 and NM23 predicts poor prognosis of human osteosarcoma. Front Genet. 2022;13:1012548. https://doi.org/10.3389/fgene.2022.1012548.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gianferante DM, Mirabello L, Savage SA. Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy. Nat Rev Endocrinol. 2017;13:480–91. https://doi.org/10.1038/nrendo.2017.16.

Article  CAS  PubMed  Google Scholar 

Tang Z, Dong H, Li T, Wang N, Wei X, Wu H, Liu Y, Wang W, Guo Z, Xiao X. The synergistic reducing drug resistance effect of cisplatin and ursolic acid on osteosarcoma through a multistep mechanism involving ferritinophagy. Oxid Med Cell Longev. 2021;2021:5192271. https://doi.org/10.1155/2021/5192271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu SN, Yao XD. Advances on immunotherapy for osteosarcoma. Mol Cancer. 2024. https://doi.org/10.1186/s12943-024-02105-9.

Article  PubMed  PubMed Central  Google Scholar 

Ogasawara Y, Cheng JL, Tatematsu T, Uchida M, Murase O, Yoshikawa S, Ohsaki Y, Fujimoto T. Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets. Nat Commun. 2020. https://doi.org/10.1038/s41467-020-18153-w.

Article  PubMed  PubMed Central  Google Scholar 

Pan Z, Cheng DD, Wei XJ, Li SJ, Guo H, Yang QC. Chitooligosaccharides inhibit tumor progression and induce autophagy through the activation of the p53/mTOR pathway in osteosarcoma. Carbohydr Polym. 2021. https://doi.org/10.1016/j.carbpol.2020.117596.

Article  PubMed  Google Scholar 

Huang X, Zhang WY, Pu FF, Zhang ZC. LncRNA MEG3 promotes chemosensitivity of osteosarcoma by regulating antitumor immunity via miR-21-5p/p53 pathway and autophagy. Genes Dis. 2023;10:531–41. https://doi.org/10.1016/j.gendis.2021.11.004.

Article  CAS  PubMed  Google Scholar 

Li J, Kim SG, Blenis J. Rapamycin: one drug, many effects. Cell Metab. 2014;19:373–9. https://doi.org/10.1016/j.cmet.2014.01.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge YX, Zhang TW, Zhou L, Ding W, Liang HF, Hu ZC, Chen Q, Dong J, Xue FF, Yin XF, Jiang LB. Enhancement of anti-PD-1/PD-L1 immunotherapy for osteosarcoma using an intelligent autophagy-controlling metal organic framework. Biomaterials. 2022. https://doi.org/10.1016/j.biomaterials.2022.121407.

Article  PubMed  Google Scholar 

Zhu ZW, Huang F, Jiang YC, Ruan SH, Liu MH, Zhang YJ, Li YC, Chen JB, Cui Y, Chen ZY, Chen HQ, Zeng F. OLMALINC/OCT4/BMP2 axis enhances osteogenic-like phenotype of renal interstitial fibroblasts to participate in Randall’s plaque formation. Mol Med. 2022. https://doi.org/10.1186/s10020-022-00576-4.

Article  PubMed  PubMed Central  Google Scholar 

Shuai ZQ, Wang ZX, Ren JL, Yang XK, Xu B. Differential expressions and potential clinical values of lncRNAs in the plasma exosomes of rheumatoid arthritis. Int Immunopharmacol. 2024. https://doi.org/10.1016/j.intimp.2024.111511.

Article  PubMed  Google Scholar 

Yu B, Liu L, Cai F, Peng YX, Tang XF, Zeng D, Li T, Zhang FF, Liang YP, Yuan XH, Li JY, Dai ZZ, Liao Q, Lv XB. The synergistic anticancer effect of the bromodomain inhibitor OTX015 and histone deacetylase 6 inhibitor WT-161 in osteosarcoma. Cancer Cell Int. 2022. https://doi.org/10.1186/s12935-022-02443-y.

Article  PubMed  PubMed Central  Google Scholar 

Zhang XM, Zheng J, Yan YQ, Ruan Z, Su YJ, Wang J, Huang HH, Zhang Y, Wang WJ, Gao JJ, Chi YF, Lu XQ, Liu ZW. Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling. Arch Biochem Biophys. 2019. https://doi.org/10.1016/j.abb.2019.07.026.

Article  PubMed  Google Scholar 

Benhammou JN, Ko A, Alvarez M, Kaikkonen MU, Rankin C, Garske KM, Padua D, Bhagat Y, Kaminska D, Kärjä V, Pihlajamaki J, Pisegna JR, Pajukant P. Novel lipid long intervening noncoding RNA, oligodendrocyte maturation-associated long intergenic noncoding RNA, regulates the liver steatosis gene stearoyl-coenzyme a desaturase as an enhancer RNA. Hepatol Commun. 2019;3:1356–72. https://doi.org/10.1002/hep4.1413.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D. Autophagy in the physiological endometrium and cancer. Autophagy. 2021;17:1077–95. https://doi.org/10.1080/15548627.2020.1752548.

Article  CAS  PubMed  Google Scholar 

Gu CY, Lin C, Zhu Z, Hu L, Wang FX, Wang XH, Ruan JP, Zhao XY, Huang S. The IFN-γ-related long non-coding RNA signature predicts prognosis and indicates immune microenvironment infiltration in uterine corpus endometrial carcinoma. Front Oncol. 2022. https://doi.org/10.3389/fonc.2022.955979.

Article  PubMed  PubMed Central  Google Scholar 

Gupta S, Silveira DA, Mombach JCM. Towards DNA-damage induced autophagy: a Boolean model of p53-induced cell fate mechanisms. DNA Repair (Amst). 2020;96: 102971. https://doi.org/10.1016/j.dnarep.2020.102971.

Article  CAS  PubMed  Google Scholar 

Wang Y, Fu YQ, Lu YY, Chen SW, Zhang J, Liu B, Yuan Y. Unravelling the complexity of lncRNAs in autophagy to improve potential cancer therapy. Biochim Biophys Acta Rev Cancer. 2023. https://doi.org/10.1016/j.bbcan.2023.188932.

Article  PubMed  PubMed Central  Google Scholar 

Xin XR, Wu MY, Meng QY, Wang C, Lu YA, Yang YX, Li XN, Zheng QD, Pu H, Gui X, Li TM, Li J, Jia S, Lu DD. Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a. Mol Cancer. 2018. https://doi.org/10.1186/s12943-018-0843-8.

Article  PubMed  PubMed Central  Google Scholar 

Lim KS, Li H, Roberts EA, Gaudiano EF, Clairmont C, Sambel LA, Ponnienselvan K, Liu JC, Yang CY, Kozono D, Parmar K, Yusufzai T, Zheng N, D’Andrea AD. USP1 is required for replication fork protection in BRCA1-deficient tumors. Mol Cell. 2018. https://doi.org/10.1016/j.molcel.2018.10.045.

Article  PubMed  PubMed Central  Google Scholar 

Li XY, Wu JC, Liu P, Li ZJ, Wang Y, Chen BY, Hu CL, Fei MY, Yu PC, Jiang YL, Xu CH, Chang BH, Chen XC, Zong LJ, Zhang JY, Fang Y, Sun XJ, Xue K, Wang L, Chen SB, Jiang SY, Gui AL, Yang L, Gu JJ, Yu BH, Zhang QL, Wang L. Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma. Leukemia. 2023;37:164–77. https://doi.org/10.1038/s41375-022-01747-2.

Article  CAS  PubMed  Google Scholar 

Wang LH, Hu T, Shen ZB, Zheng YY, Geng QS, Li LF, Sha BB, Li MM, Sun YX, Guo YJ, Xue WH, Xuan D, Chen P, Zhao J. Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC. Cell Death Dis. 2022. https://doi.org/10.1038/s41419-022-05341-3.

Article  PubMed  PubMed Central  Google Scholar 

Sun YX, Sha BB, Huang WJ, Li MM, Zhao S, Zhang Y, Yan J, Li Z, Tang JW, Duan PY, Shi JX, Li P, Hu T, Chen P. ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells. Apoptosis. 2022;27:545–60. https://doi.org/10.1007/s10495-022-01736-x.

Article  CAS  PubMed  Google Scholar 

Williams SA, Maecker HL, French DM, Liu JF, Gregg A, Silverstein LB, Cao TC, Carano RAD, Dixit VM. USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell. 2011.